ENSG00000112739

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000337659 ENSG00000112739 HEK293_DMSO_6hA HEK293_OSMI2_6hA PRPF4B protein_coding protein_coding 29.95052 9.252678 9.232087 2.905899 0.4182955 -0.003210638 5.0338773 2.42542164 1.6818898 0.81191824 0.1138226 -0.5255360 0.17568333 0.25953333 0.18296667 -0.07656667 3.553045e-01 2.331863e-05 FALSE TRUE
ENST00000461612 ENSG00000112739 HEK293_DMSO_6hA HEK293_OSMI2_6hA PRPF4B protein_coding processed_transcript 29.95052 9.252678 9.232087 2.905899 0.4182955 -0.003210638 1.2303428 0.82754759 0.2264780 0.20706903 0.1588281 -1.8244649 0.05708333 0.09333333 0.02473333 -0.06860000 2.981084e-01 2.331863e-05   FALSE
ENST00000480058 ENSG00000112739 HEK293_DMSO_6hA HEK293_OSMI2_6hA PRPF4B protein_coding nonsense_mediated_decay 29.95052 9.252678 9.232087 2.905899 0.4182955 -0.003210638 5.1558915 2.02453506 1.4846082 0.40282404 0.2793919 -0.4449318 0.20922917 0.23350000 0.16166667 -0.07183333 6.088945e-01 2.331863e-05 TRUE TRUE
ENST00000481109 ENSG00000112739 HEK293_DMSO_6hA HEK293_OSMI2_6hA PRPF4B protein_coding nonsense_mediated_decay 29.95052 9.252678 9.232087 2.905899 0.4182955 -0.003210638 0.4597196 0.51231387 0.0000000 0.08358432 0.0000000 -5.7068451 0.05082500 0.06170000 0.00000000 -0.06170000 2.331863e-05 2.331863e-05 TRUE TRUE
MSTRG.27573.11 ENSG00000112739 HEK293_DMSO_6hA HEK293_OSMI2_6hA PRPF4B protein_coding   29.95052 9.252678 9.232087 2.905899 0.4182955 -0.003210638 1.5055540 0.75774969 0.9464706 0.51703188 0.2585606 0.3170846 0.06392083 0.07023333 0.10133333 0.03110000 7.582382e-01 2.331863e-05 TRUE TRUE
MSTRG.27573.14 ENSG00000112739 HEK293_DMSO_6hA HEK293_OSMI2_6hA PRPF4B protein_coding   29.95052 9.252678 9.232087 2.905899 0.4182955 -0.003210638 5.1115198 0.06197324 1.0840953 0.06197324 0.2826680 3.9261339 0.11642083 0.01106667 0.11770000 0.10663333 1.220286e-01 2.331863e-05 TRUE TRUE
MSTRG.27573.7 ENSG00000112739 HEK293_DMSO_6hA HEK293_OSMI2_6hA PRPF4B protein_coding   29.95052 9.252678 9.232087 2.905899 0.4182955 -0.003210638 3.5439341 1.52574553 1.9906331 0.66450773 0.3894468 0.3815174 0.11676667 0.15720000 0.21276667 0.05556667 7.281531e-01 2.331863e-05 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000112739 E001 0.0000000       6 4020977 4021105 129 +      
ENSG00000112739 E002 0.0000000       6 4021106 4021257 152 +      
ENSG00000112739 E003 0.0000000       6 4021258 4021266 9 +      
ENSG00000112739 E004 0.0000000       6 4021267 4021277 11 +      
ENSG00000112739 E005 0.0000000       6 4021278 4021288 11 +      
ENSG00000112739 E006 0.0000000       6 4021289 4021290 2 +      
ENSG00000112739 E007 0.0000000       6 4021291 4021293 3 +      
ENSG00000112739 E008 0.0000000       6 4021294 4021296 3 +      
ENSG00000112739 E009 0.1717682 0.0439694699 0.4979096958   6 4021297 4021298 2 + 0.000 0.121 9.758
ENSG00000112739 E010 0.1717682 0.0439694699 0.4979096958   6 4021299 4021299 1 + 0.000 0.121 9.773
ENSG00000112739 E011 0.1717682 0.0439694699 0.4979096958   6 4021300 4021301 2 + 0.000 0.121 9.773
ENSG00000112739 E012 2.1034596 0.0093112621 0.6529875135 0.897743384 6 4021302 4021316 15 + 0.459 0.552 0.449
ENSG00000112739 E013 28.1066931 0.0129156495 0.6551584051 0.898767730 6 4021317 4021466 150 + 1.471 1.462 -0.032
ENSG00000112739 E014 255.8740535 0.0047705198 0.1536816679 0.544432984 6 4031559 4032755 1197 + 2.426 2.398 -0.092
ENSG00000112739 E015 40.6804857 0.0088352404 0.5181489020 0.839189153 6 4037397 4037418 22 + 1.636 1.615 -0.072
ENSG00000112739 E016 78.1106026 0.0020377432 0.4311135316 0.792526235 6 4037419 4037570 152 + 1.909 1.899 -0.031
ENSG00000112739 E017 64.7261318 0.0006057210 0.9385053595 0.985605762 6 4040772 4040847 76 + 1.806 1.836 0.101
ENSG00000112739 E018 38.2710419 0.0197497173 0.5597867509 0.857931467 6 4040848 4040848 1 + 1.555 1.629 0.254
ENSG00000112739 E019 59.7978524 0.0024954239 0.2328119915 0.637796707 6 4040849 4040927 79 + 1.744 1.827 0.282
ENSG00000112739 E020 59.3642939 0.0005429397 0.6796212550 0.908015598 6 4042487 4042568 82 + 1.782 1.789 0.025
ENSG00000112739 E021 94.9288627 0.0003764391 0.0140422318 0.202958935 6 4043813 4044023 211 + 2.014 1.951 -0.209
ENSG00000112739 E022 0.2669773 0.0274424043 0.9869445453   6 4044024 4044226 203 + 0.118 0.121 0.035
ENSG00000112739 E023 56.2533218 0.0005545476 0.0002604141 0.024145383 6 4047175 4047248 74 + 1.825 1.682 -0.484
ENSG00000112739 E024 68.8666023 0.0082285374 0.0397875537 0.313526831 6 4049016 4049106 91 + 1.889 1.805 -0.284
ENSG00000112739 E025 88.1593385 0.0028482430 0.0129621973 0.195981091 6 4049732 4049879 148 + 1.993 1.912 -0.271
ENSG00000112739 E026 43.5608571 0.0007282036 0.0940502951 0.446146808 6 4051957 4051981 25 + 1.679 1.617 -0.211
ENSG00000112739 E027 70.3986975 0.0007698554 0.0086108529 0.161926444 6 4051982 4052094 113 + 1.895 1.809 -0.290
ENSG00000112739 E028 79.5989700 0.0004045618 0.0313381578 0.284806596 6 4052720 4052873 154 + 1.934 1.877 -0.194
ENSG00000112739 E029 70.6353018 0.0010303799 0.0002963714 0.026150911 6 4056321 4056435 115 + 1.921 1.791 -0.438
ENSG00000112739 E030 3.6272267 0.0171089279 0.4694853565 0.813675431 6 4056436 4056526 91 + 0.584 0.713 0.554
ENSG00000112739 E031 6.5894052 0.0036652400 0.3489438891 0.738547630 6 4056527 4056688 162 + 0.802 0.939 0.528
ENSG00000112739 E032 5.4075808 0.0164856898 0.5127344650 0.836406834 6 4056689 4057035 347 + 0.734 0.850 0.458
ENSG00000112739 E033 81.2022820 0.0004008695 0.0000325979 0.006668846 6 4057036 4057159 124 + 1.982 1.848 -0.450
ENSG00000112739 E034 48.7500578 0.0006330259 0.0078861385 0.155360583 6 4057160 4057187 28 + 1.752 1.646 -0.359
ENSG00000112739 E035 68.9835256 0.0047525824 0.0446881311 0.329097401 6 4058728 4058814 87 + 1.892 1.810 -0.277
ENSG00000112739 E036 2.2046553 0.0087040722 0.1285430332 0.508053635 6 4058815 4058890 76 + 0.353 0.623 1.353
ENSG00000112739 E037 117.9129859 0.0013638334 0.0130480032 0.196507459 6 4060413 4060644 232 + 2.112 2.049 -0.212
ENSG00000112739 E038 44.0433800 0.0006367955 0.7102242459 0.918780196 6 4060645 4060686 42 + 1.652 1.658 0.021
ENSG00000112739 E039 107.3736738 0.0138267047 0.7148840869 0.920306144 6 4060687 4060981 295 + 2.015 2.051 0.122
ENSG00000112739 E040 48.5366350 0.0013431767 0.2059252130 0.609732867 6 4060982 4061014 33 + 1.643 1.734 0.306
ENSG00000112739 E041 94.8431427 0.0006052845 0.7800408285 0.942247645 6 4061015 4061147 133 + 1.962 2.000 0.126
ENSG00000112739 E042 135.4659522 0.0183680779 0.2379326998 0.643085789 6 4061148 4061654 507 + 2.081 2.177 0.321
ENSG00000112739 E043 67.1930824 0.0189211769 0.1832670836 0.583379856 6 4061655 4061700 46 + 1.769 1.884 0.388
ENSG00000112739 E044 89.9615198 0.0035326352 0.0005952335 0.040322021 6 4061701 4062103 403 + 1.856 2.033 0.592
ENSG00000112739 E045 36.8363602 0.0304732819 0.4131084811 0.782403445 6 4062104 4062212 109 + 1.533 1.613 0.272
ENSG00000112739 E046 31.8345735 0.0309563583 0.6363602431 0.890833379 6 4062213 4062214 2 + 1.485 1.543 0.199
ENSG00000112739 E047 36.0214264 0.0438118103 0.7795356981 0.942189618 6 4062215 4062220 6 + 1.547 1.586 0.131
ENSG00000112739 E048 59.2272269 0.0477090793 0.6856673025 0.910198701 6 4062221 4062299 79 + 1.756 1.800 0.149
ENSG00000112739 E049 18.8518579 0.0226275095 0.2253581253 0.630414599 6 4062300 4062556 257 + 1.215 1.366 0.529
ENSG00000112739 E050 43.0099241 0.0401414744 0.5214554803 0.840767367 6 4062557 4062633 77 + 1.599 1.684 0.286
ENSG00000112739 E051 17.9323567 0.0017076649 0.6132130266 0.881438871 6 4062634 4062760 127 + 1.239 1.306 0.236
ENSG00000112739 E052 29.2200736 0.0009838592 0.0008963575 0.050862673 6 4062761 4063073 313 + 1.336 1.578 0.832
ENSG00000112739 E053 44.4090512 0.0574147928 0.2302427439 0.635158504 6 4063074 4063119 46 + 1.586 1.713 0.434
ENSG00000112739 E054 170.5626522 0.0194909104 0.0000609889 0.010198194 6 4063120 4064800 1681 + 2.059 2.347 0.963
ENSG00000112739 E055 50.8731176 0.0068315975 0.0014408036 0.066709729 6 4064801 4064983 183 + 1.586 1.805 0.744