ENSG00000112062

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000229794 ENSG00000112062 HEK293_DMSO_6hA HEK293_OSMI2_6hA MAPK14 protein_coding protein_coding 22.16149 19.06398 13.58927 2.508967 1.680604 -0.4880767 7.968105 2.764394 5.730740 0.8430097 0.6753083 1.0490638 0.3479167 0.1411667 0.4456667 0.3045000 0.0273781 0.0273781 FALSE TRUE
ENST00000229795 ENSG00000112062 HEK293_DMSO_6hA HEK293_OSMI2_6hA MAPK14 protein_coding protein_coding 22.16149 19.06398 13.58927 2.508967 1.680604 -0.4880767 5.614843 4.838709 3.995340 0.4039619 0.6149562 -0.2756759 0.2556125 0.2587000 0.2925000 0.0338000 0.7518181 0.0273781 FALSE TRUE
ENST00000468133 ENSG00000112062 HEK293_DMSO_6hA HEK293_OSMI2_6hA MAPK14 protein_coding protein_coding 22.16149 19.06398 13.58927 2.508967 1.680604 -0.4880767 5.628678 8.955812 2.946233 0.9038650 1.7445250 -1.6006744 0.2722292 0.4736667 0.1908000 -0.2828667 0.7116519 0.0273781 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000112062 E001 0.1717682 0.0360718676 6.804230e-01   6 36027677 36027710 34 + 0.000 0.104 8.043
ENSG00000112062 E002 4.8998764 0.0075297935 3.277937e-01 0.7228953807 6 36027711 36027781 71 + 0.819 0.703 -0.466
ENSG00000112062 E003 9.3373894 0.0026642849 2.610776e-01 0.6663429776 6 36027782 36027807 26 + 1.058 0.959 -0.365
ENSG00000112062 E004 30.0549926 0.0010182959 2.836322e-04 0.0254647942 6 36027808 36027884 77 + 1.595 1.389 -0.708
ENSG00000112062 E005 68.7926413 0.0006497989 1.122191e-08 0.0000180541 6 36027885 36028157 273 + 1.948 1.725 -0.750
ENSG00000112062 E006 43.5376350 0.0110759592 4.617823e-02 0.3332962519 6 36028158 36028190 33 + 1.707 1.579 -0.434
ENSG00000112062 E007 38.9879010 0.0052977301 2.562965e-01 0.6620622637 6 36028191 36028198 8 + 1.621 1.567 -0.183
ENSG00000112062 E008 72.8988347 0.0123036223 8.562166e-01 0.9645129962 6 36028199 36028273 75 + 1.854 1.857 0.009
ENSG00000112062 E009 0.0000000       6 36029089 36029160 72 +      
ENSG00000112062 E010 111.0905165 0.0045080309 1.585412e-01 0.5519497786 6 36052699 36052828 130 + 2.064 2.017 -0.156
ENSG00000112062 E011 81.3891858 0.0029053277 4.654347e-01 0.8113879276 6 36059289 36059347 59 + 1.913 1.900 -0.045
ENSG00000112062 E012 121.4138486 0.0013672124 4.060719e-01 0.7775501764 6 36072873 36072984 112 + 2.079 2.070 -0.030
ENSG00000112062 E013 0.0000000       6 36073046 36073105 60 +      
ENSG00000112062 E014 83.5184705 0.0004050364 1.976336e-01 0.6007790659 6 36073691 36073720 30 + 1.929 1.900 -0.095
ENSG00000112062 E015 89.6993789 0.0003074505 1.417554e-01 0.5276669611 6 36074049 36074096 48 + 1.963 1.930 -0.110
ENSG00000112062 E016 1.3416120 0.2392051850 5.609331e-01   6 36075821 36075847 27 + 0.241 0.422 1.148
ENSG00000112062 E017 76.6838861 0.0003545639 8.025795e-01 0.9490516621 6 36075848 36075864 17 + 1.869 1.881 0.040
ENSG00000112062 E018 126.2589982 0.0005868047 4.422489e-01 0.7988921374 6 36075865 36075962 98 + 2.090 2.086 -0.012
ENSG00000112062 E019 108.5523041 0.0040651409 8.935685e-01 0.9746377147 6 36076537 36076608 72 + 2.011 2.036 0.085
ENSG00000112062 E020 6.9973473 0.1217717101 4.093094e-01 0.7799352124 6 36076609 36076888 280 + 0.798 0.945 0.565
ENSG00000112062 E021 81.4427903 0.0003525241 7.381984e-01 0.9284511420 6 36095987 36096066 80 + 1.895 1.904 0.029
ENSG00000112062 E022 21.5762459 0.1604277456 1.616048e-01 0.5563203294 6 36096067 36098054 1988 + 1.198 1.413 0.751
ENSG00000112062 E023 3.3493869 0.0087981561 2.603547e-01 0.6658037172 6 36100179 36100187 9 + 0.509 0.703 0.858
ENSG00000112062 E024 40.2336571 0.0017754746 7.594183e-01 0.9356872119 6 36100188 36100267 80 + 1.582 1.621 0.133
ENSG00000112062 E025 132.3552137 0.0002508273 8.824076e-01 0.9718130340 6 36102571 36102649 79 + 2.094 2.121 0.089
ENSG00000112062 E026 207.7371836 0.0005901549 5.827243e-01 0.8680100540 6 36107455 36107628 174 + 2.283 2.319 0.119
ENSG00000112062 E027 1373.3562787 0.0018904182 3.383566e-03 0.1047275271 6 36108380 36111236 2857 + 3.092 3.148 0.187