ENSG00000111785

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000392837 ENSG00000111785 HEK293_DMSO_6hA HEK293_OSMI2_6hA RIC8B protein_coding protein_coding 5.565053 2.604318 2.873869 0.7304188 0.5251606 0.1415714 0.6248107 0.33811223 0.4076241 0.15571912 0.13663489 0.262652558 0.1201333 0.11700000 0.13706667 0.02006667 0.87757784 0.03677511 FALSE TRUE
ENST00000392839 ENSG00000111785 HEK293_DMSO_6hA HEK293_OSMI2_6hA RIC8B protein_coding protein_coding 5.565053 2.604318 2.873869 0.7304188 0.5251606 0.1415714 2.1928351 1.31707148 1.3244702 0.28664276 0.33456967 0.008020983 0.4561750 0.52256667 0.45180000 -0.07076667 0.75179833 0.03677511 FALSE TRUE
ENST00000548914 ENSG00000111785 HEK293_DMSO_6hA HEK293_OSMI2_6hA RIC8B protein_coding protein_coding 5.565053 2.604318 2.873869 0.7304188 0.5251606 0.1415714 1.3241675 0.05873280 0.5552645 0.05873280 0.16689677 3.039855459 0.1859333 0.01466667 0.18503333 0.17036667 0.03677511 0.03677511 FALSE TRUE
ENST00000550215 ENSG00000111785 HEK293_DMSO_6hA HEK293_OSMI2_6hA RIC8B protein_coding nonsense_mediated_decay 5.565053 2.604318 2.873869 0.7304188 0.5251606 0.1415714 0.3266747 0.05795833 0.2457404 0.02923858 0.14819165 1.911957865 0.0546125 0.02686667 0.09273333 0.06586667 0.74167844 0.03677511 FALSE FALSE
MSTRG.7939.5 ENSG00000111785 HEK293_DMSO_6hA HEK293_OSMI2_6hA RIC8B protein_coding   5.565053 2.604318 2.873869 0.7304188 0.5251606 0.1415714 0.4867312 0.60805366 0.1714753 0.21691912 0.09750608 -1.767958520 0.0940250 0.22446667 0.07843333 -0.14603333 0.39581291 0.03677511 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000111785 E001 1.7808297 0.0100377646 6.180277e-01 8.831807e-01 12 106774621 106774639 19 + 0.480 0.397 -0.433
ENSG00000111785 E002 5.9729031 0.0148170240 5.457877e-02 3.573302e-01 12 106774640 106774662 23 + 0.971 0.715 -0.998
ENSG00000111785 E003 6.6677195 0.0044843098 8.663376e-02 4.311498e-01 12 106774663 106774670 8 + 0.988 0.784 -0.779
ENSG00000111785 E004 7.1506092 0.0038324918 6.497729e-02 3.843076e-01 12 106774671 106774681 11 + 1.017 0.805 -0.805
ENSG00000111785 E005 9.0338897 0.0027289125 8.080286e-02 4.191767e-01 12 106774682 106774713 32 + 1.094 0.912 -0.670
ENSG00000111785 E006 10.1034313 0.0026113143 1.464599e-01 5.342928e-01 12 106774714 106774745 32 + 1.117 0.972 -0.531
ENSG00000111785 E007 10.8320269 0.0024375547 7.248602e-02 4.011907e-01 12 106774746 106774829 84 + 1.159 0.985 -0.632
ENSG00000111785 E008 0.0000000       12 106775324 106775425 102 +      
ENSG00000111785 E009 7.9442303 0.0036084173 1.687083e-02 2.198528e-01 12 106783997 106784044 48 + 1.071 0.805 -1.001
ENSG00000111785 E010 0.0000000       12 106797977 106798069 93 +      
ENSG00000111785 E011 49.6283579 0.0007215425 3.686369e-03 1.091219e-01 12 106814696 106815304 609 + 1.774 1.641 -0.452
ENSG00000111785 E012 3.3486975 0.0062415235 7.113257e-01 9.191983e-01 12 106822258 106823447 1190 + 0.605 0.662 0.247
ENSG00000111785 E013 22.6432045 0.0014875499 2.365533e-01 6.414995e-01 12 106825726 106825820 95 + 1.319 1.407 0.305
ENSG00000111785 E014 35.5669667 0.0017740537 3.145652e-01 7.119090e-01 12 106842589 106842817 229 + 1.587 1.530 -0.196
ENSG00000111785 E015 21.9534984 0.0043240883 1.453351e-02 2.059157e-01 12 106843852 106843947 96 + 1.455 1.277 -0.619
ENSG00000111785 E016 25.0373890 0.0012306250 3.322141e-02 2.913351e-01 12 106851450 106851594 145 + 1.485 1.347 -0.479
ENSG00000111785 E017 28.3783124 0.0031583746 4.621156e-02 3.333742e-01 12 106860268 106860412 145 + 1.531 1.401 -0.448
ENSG00000111785 E018 0.8398352 0.0165588606 2.405773e-02   12 106868301 106868423 123 + 0.000 0.397 10.548
ENSG00000111785 E019 7.3676695 0.0177770319 3.130520e-01 7.105575e-01 12 106870823 106870942 120 + 0.999 0.878 -0.453
ENSG00000111785 E020 0.9099321 0.0462339438 1.426166e-01   12 106870943 106871505 563 + 0.125 0.396 2.155
ENSG00000111785 E021 0.4465501 0.0217681645 6.429660e-01   12 106873032 106873174 143 + 0.126 0.204 0.835
ENSG00000111785 E022 1.2338343 0.0127893592 5.916011e-01   12 106874481 106874567 87 + 0.302 0.397 0.571
ENSG00000111785 E023 7.2928377 0.0035771536 1.544268e-02 2.112130e-01 12 106878987 106879125 139 + 0.730 1.024 1.130
ENSG00000111785 E024 1.2245652 0.0160052214 8.322242e-01   12 106879728 106879774 47 + 0.303 0.342 0.243
ENSG00000111785 E025 8.3188557 0.0187401232 4.694473e-02 3.357902e-01 12 106879775 106879947 173 + 0.807 1.058 0.949
ENSG00000111785 E026 213.5040093 0.0003590521 4.765433e-12 3.037212e-08 12 106885904 106889316 3413 + 2.251 2.383 0.443