ENSG00000111652

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000229251 ENSG00000111652 HEK293_DMSO_6hA HEK293_OSMI2_6hA COPS7A protein_coding protein_coding 67.0829 53.43168 89.53858 4.630048 13.84412 0.7447052 4.878584 1.320321 7.375407 0.7218475 1.696740 2.4729031 0.06441667 0.02713333 0.08020000 0.0530666667 6.959224e-01 6.695959e-23 FALSE TRUE
ENST00000455113 ENSG00000111652 HEK293_DMSO_6hA HEK293_OSMI2_6hA COPS7A protein_coding nonsense_mediated_decay 67.0829 53.43168 89.53858 4.630048 13.84412 0.7447052 3.797055 2.892998 5.492278 0.1706566 1.158816 0.9224855 0.05815833 0.05510000 0.06590000 0.0108000000 9.159561e-01 6.695959e-23   FALSE
ENST00000534947 ENSG00000111652 HEK293_DMSO_6hA HEK293_OSMI2_6hA COPS7A protein_coding protein_coding 67.0829 53.43168 89.53858 4.630048 13.84412 0.7447052 2.712618 4.085764 0.000000 0.7675074 0.000000 -8.6779886 0.03529583 0.07960000 0.00000000 -0.0796000000 6.695959e-23 6.695959e-23 FALSE TRUE
ENST00000539735 ENSG00000111652 HEK293_DMSO_6hA HEK293_OSMI2_6hA COPS7A protein_coding protein_coding 67.0829 53.43168 89.53858 4.630048 13.84412 0.7447052 8.451743 7.704914 13.122057 0.5744619 2.431514 0.7673709 0.12599167 0.14496667 0.14513333 0.0001666667 1.000000e+00 6.695959e-23 FALSE TRUE
ENST00000541866 ENSG00000111652 HEK293_DMSO_6hA HEK293_OSMI2_6hA COPS7A protein_coding protein_coding 67.0829 53.43168 89.53858 4.630048 13.84412 0.7447052 3.396460 1.187001 6.800959 1.1870006 1.557167 2.5084342 0.05990000 0.02066667 0.07396667 0.0533000000 3.100706e-01 6.695959e-23 FALSE FALSE
ENST00000543155 ENSG00000111652 HEK293_DMSO_6hA HEK293_OSMI2_6hA COPS7A protein_coding protein_coding 67.0829 53.43168 89.53858 4.630048 13.84412 0.7447052 31.666156 24.194968 42.004310 3.6011576 8.272826 0.7955776 0.46656667 0.44813333 0.46143333 0.0133000000 9.217169e-01 6.695959e-23 FALSE TRUE
ENST00000626119 ENSG00000111652 HEK293_DMSO_6hA HEK293_OSMI2_6hA COPS7A protein_coding protein_coding 67.0829 53.43168 89.53858 4.630048 13.84412 0.7447052 5.190218 5.361339 6.465544 1.2542954 1.801904 0.2697197 0.07856667 0.09763333 0.07156667 -0.0260666667 6.985786e-01 6.695959e-23 TRUE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000111652 E001 8.384897 3.050772e-03 0.3943648531 0.7696073 12 6724014 6724038 25 + 0.931 1.027 0.355
ENSG00000111652 E002 10.468394 2.543366e-03 0.3469251179 0.7368163 12 6724039 6724045 7 + 1.015 1.113 0.353
ENSG00000111652 E003 56.850212 5.221652e-04 0.2905383712 0.6918862 12 6724046 6724070 25 + 1.780 1.734 -0.156
ENSG00000111652 E004 69.330028 5.097393e-04 0.1346892338 0.5173192 12 6724071 6724078 8 + 1.871 1.811 -0.204
ENSG00000111652 E005 70.832892 4.943273e-04 0.1150123277 0.4843821 12 6724079 6724080 2 + 1.882 1.818 -0.213
ENSG00000111652 E006 71.099869 5.173324e-04 0.1212761302 0.4959551 12 6724081 6724081 1 + 1.883 1.821 -0.210
ENSG00000111652 E007 86.315540 3.456151e-04 0.3996875683 0.7731918 12 6724082 6724089 8 + 1.950 1.922 -0.095
ENSG00000111652 E008 107.820840 2.703870e-04 0.2728544359 0.6767050 12 6724090 6724110 21 + 2.048 2.014 -0.113
ENSG00000111652 E009 114.553226 2.706164e-04 0.2354122959 0.6403129 12 6724111 6724118 8 + 2.073 2.038 -0.120
ENSG00000111652 E010 151.891021 2.203185e-04 0.2544507772 0.6600968 12 6724119 6724134 16 + 2.191 2.162 -0.097
ENSG00000111652 E011 175.192735 4.118928e-04 0.3415159298 0.7331459 12 6724135 6724152 18 + 2.250 2.228 -0.074
ENSG00000111652 E012 164.238421 2.945778e-03 0.8092574919 0.9512616 12 6724153 6724179 27 + 2.213 2.211 -0.006
ENSG00000111652 E013 30.059818 1.355172e-03 0.8034764959 0.9493568 12 6724180 6724183 4 + 1.494 1.482 -0.042
ENSG00000111652 E014 56.152992 6.327769e-04 0.4443383475 0.8002398 12 6724184 6724250 67 + 1.764 1.731 -0.110
ENSG00000111652 E015 2.740535 7.552033e-03 0.2722898442 0.6761911 12 6724251 6724266 16 + 0.642 0.467 -0.812
ENSG00000111652 E016 1.121318 1.369686e-02 0.1029940649   12 6724287 6724290 4 + 0.182 0.467 1.889
ENSG00000111652 E017 1.293086 1.247086e-02 0.0513255469   12 6724291 6724292 2 + 0.182 0.520 2.152
ENSG00000111652 E018 1.560063 1.351075e-02 0.0642502812   12 6724293 6724293 1 + 0.250 0.568 1.791
ENSG00000111652 E019 3.113660 6.943092e-03 0.0040697723 0.1141693 12 6724294 6724297 4 + 0.362 0.806 2.052
ENSG00000111652 E020 7.165753 3.496159e-03 0.0101400663 0.1745948 12 6724298 6724305 8 + 0.755 1.057 1.153
ENSG00000111652 E021 9.572857 2.784950e-03 0.0362949988 0.3015799 12 6724306 6724330 25 + 0.918 1.138 0.806
ENSG00000111652 E022 10.295136 2.498200e-03 0.1979404192 0.6010786 12 6724331 6724368 38 + 0.993 1.125 0.481
ENSG00000111652 E023 10.007487 2.611578e-03 0.2076360294 0.6115748 12 6724369 6724378 10 + 0.982 1.113 0.478
ENSG00000111652 E024 10.075257 2.618833e-03 0.5054680927 0.8324119 12 6724379 6724436 58 + 1.015 1.086 0.257
ENSG00000111652 E025 61.663888 3.873893e-03 0.5932380227 0.8727041 12 6724437 6724613 177 + 1.782 1.814 0.108
ENSG00000111652 E026 646.165405 9.839109e-05 0.0162842171 0.2163364 12 6724614 6724818 205 + 2.818 2.789 -0.097
ENSG00000111652 E027 5.673955 2.104305e-01 0.1939304841 0.5963485 12 6725648 6725757 110 + 0.669 0.945 1.091
ENSG00000111652 E028 3.157332 1.166492e-02 0.0001428299 0.0167382 12 6725865 6725959 95 + 0.251 0.856 2.981
ENSG00000111652 E029 8.435841 7.193653e-02 0.0056777777 0.1342933 12 6727671 6727800 130 + 0.716 1.171 1.716
ENSG00000111652 E030 406.153528 1.231427e-03 0.8804522118 0.9713263 12 6727926 6728001 76 + 2.604 2.606 0.006
ENSG00000111652 E031 549.091384 1.035745e-04 0.8480160547 0.9624138 12 6728223 6728311 89 + 2.733 2.735 0.005
ENSG00000111652 E032 12.385440 8.875367e-02 0.0562668281 0.3617428 12 6729035 6729246 212 + 0.959 1.264 1.100
ENSG00000111652 E033 413.148451 1.112623e-04 0.1995428737 0.6028268 12 6729247 6729300 54 + 2.600 2.627 0.089
ENSG00000111652 E034 401.830438 1.519960e-04 0.6765366408 0.9068785 12 6729301 6729360 60 + 2.593 2.605 0.041
ENSG00000111652 E035 486.125704 1.056360e-04 0.4486477641 0.8028528 12 6729361 6729449 89 + 2.675 2.691 0.055
ENSG00000111652 E036 3.114875 5.419533e-02 0.7076768730 0.9179584 12 6729450 6729452 3 + 0.587 0.650 0.275
ENSG00000111652 E037 459.874032 1.116118e-04 0.6726131763 0.9050064 12 6730402 6730507 106 + 2.654 2.665 0.037
ENSG00000111652 E038 4.056825 2.034765e-01 0.1212349799 0.4958835 12 6730508 6730509 2 + 0.504 0.857 1.498
ENSG00000111652 E039 493.822373 3.388553e-04 0.0120897553 0.1900409 12 6730669 6730820 152 + 2.708 2.668 -0.133
ENSG00000111652 E040 19.544101 6.474528e-02 0.7565059999 0.9346698 12 6730821 6730821 1 + 1.272 1.355 0.288
ENSG00000111652 E041 1699.986960 1.252912e-03 0.2037472411 0.6075841 12 6731000 6731875 876 + 3.212 3.242 0.100