ENSG00000111639

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000229238 ENSG00000111639 HEK293_DMSO_6hA HEK293_OSMI2_6hA MRPL51 protein_coding protein_coding 280.2722 248.9918 205.9097 25.21223 25.61462 -0.2740738 175.98850 154.08235 146.83009 11.237110 18.801285 -0.06954937 0.6260042 0.6223333 0.7122000 0.08986667 0.01776654 0.01776654 FALSE FALSE
ENST00000537701 ENSG00000111639 HEK293_DMSO_6hA HEK293_OSMI2_6hA MRPL51 protein_coding protein_coding 280.2722 248.9918 205.9097 25.21223 25.61462 -0.2740738 43.45753 41.26054 24.76434 6.124627 1.842286 -0.73626568 0.1563708 0.1641667 0.1220667 -0.04210000 0.12120810 0.01776654 FALSE FALSE
ENST00000543164 ENSG00000111639 HEK293_DMSO_6hA HEK293_OSMI2_6hA MRPL51 protein_coding protein_coding 280.2722 248.9918 205.9097 25.21223 25.61462 -0.2740738 43.08804 41.96524 26.59533 6.602952 2.937708 -0.65782346 0.1554042 0.1668333 0.1296000 -0.03723333 0.11433407 0.01776654   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000111639 E001 15.82719 6.088195e-03 9.198502e-01 0.980785163 12 6491886 6492102 217 - 1.223 1.214 -0.031
ENSG00000111639 E002 16.80486 1.368651e-02 4.072600e-01 0.778395735 12 6492103 6492146 44 - 1.192 1.276 0.294
ENSG00000111639 E003 33.97089 5.240959e-03 4.022159e-01 0.774982149 12 6492147 6492150 4 - 1.497 1.555 0.200
ENSG00000111639 E004 33.78631 3.965275e-03 3.413627e-01 0.733030482 12 6492151 6492151 1 - 1.492 1.555 0.216
ENSG00000111639 E005 915.53182 3.894518e-03 2.953869e-01 0.695851351 12 6492152 6492280 129 - 2.934 2.963 0.094
ENSG00000111639 E006 2340.83661 6.447460e-04 8.993820e-01 0.975971290 12 6492281 6492467 187 - 3.361 3.356 -0.018
ENSG00000111639 E007 2449.56468 4.325741e-05 2.591519e-02 0.261932322 12 6492862 6492972 111 - 3.384 3.367 -0.057
ENSG00000111639 E008 15.68320 2.560080e-03 6.607621e-01 0.900829826 12 6492973 6493046 74 - 1.185 1.221 0.126
ENSG00000111639 E009 2165.59070 1.793280e-03 3.338847e-02 0.291966738 12 6493058 6493250 193 - 3.352 3.308 -0.148
ENSG00000111639 E010 242.27789 4.208774e-03 7.863709e-03 0.155360583 12 6493251 6493295 45 - 2.438 2.327 -0.369
ENSG00000111639 E011 369.75110 2.605433e-03 5.129661e-05 0.009149957 12 6493459 6493673 215 - 2.475 2.604 0.427
ENSG00000111639 E012 198.66157 1.782139e-04 2.584105e-06 0.001148747 12 6493674 6493716 43 - 2.209 2.330 0.403
ENSG00000111639 E013 331.39898 4.197560e-03 1.170112e-04 0.014722706 12 6493717 6493841 125 - 2.420 2.561 0.469