ENSG00000111364

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000238146 ENSG00000111364 HEK293_DMSO_6hA HEK293_OSMI2_6hA DDX55 protein_coding protein_coding 29.62184 25.94512 21.11372 4.388428 1.068462 -0.2971552 10.3244434 6.317675 7.740256 1.5892386 1.68292660 0.2925684 0.360029167 0.23750000 0.37320000 0.13570000 5.182926e-01 1.452614e-13 FALSE  
ENST00000421670 ENSG00000111364 HEK293_DMSO_6hA HEK293_OSMI2_6hA DDX55 protein_coding protein_coding 29.62184 25.94512 21.11372 4.388428 1.068462 -0.2971552 2.4858199 3.639440 1.380467 0.5622167 0.43471585 -1.3921059 0.084179167 0.14086667 0.06393333 -0.07693333 1.330667e-01 1.452614e-13 FALSE  
ENST00000536079 ENSG00000111364 HEK293_DMSO_6hA HEK293_OSMI2_6hA DDX55 protein_coding retained_intron 29.62184 25.94512 21.11372 4.388428 1.068462 -0.2971552 3.3876595 2.986152 1.740058 0.7228320 0.44843518 -0.7757083 0.105304167 0.11296667 0.08060000 -0.03236667 6.901782e-01 1.452614e-13 FALSE  
ENST00000542286 ENSG00000111364 HEK293_DMSO_6hA HEK293_OSMI2_6hA DDX55 protein_coding retained_intron 29.62184 25.94512 21.11372 4.388428 1.068462 -0.2971552 1.5239063 2.624645 1.334397 0.2936018 0.68423301 -0.9706497 0.051304167 0.10303333 0.06096667 -0.04206667 5.268336e-01 1.452614e-13 FALSE  
MSTRG.8253.22 ENSG00000111364 HEK293_DMSO_6hA HEK293_OSMI2_6hA DDX55 protein_coding   29.62184 25.94512 21.11372 4.388428 1.068462 -0.2971552 0.2003065 1.602452 0.000000 0.1286998 0.00000000 -7.3331127 0.008108333 0.06486667 0.00000000 -0.06486667 1.884065e-12 1.452614e-13 TRUE  
MSTRG.8253.8 ENSG00000111364 HEK293_DMSO_6hA HEK293_OSMI2_6hA DDX55 protein_coding   29.62184 25.94512 21.11372 4.388428 1.068462 -0.2971552 1.3171530 0.000000 1.201188 0.0000000 0.09922287 6.9202795 0.044212500 0.00000000 0.05710000 0.05710000 1.452614e-13 1.452614e-13 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000111364 E001 0.871648 0.1599257751 3.299971e-01   12 123602068 123602076 9 + 0.133 0.330 1.662
ENSG00000111364 E002 1.576530 0.4636029976 6.072920e-01   12 123602077 123602096 20 + 0.330 0.436 0.603
ENSG00000111364 E003 1.220187 0.3896916445 5.781266e-01   12 123602097 123602098 2 + 0.241 0.386 0.948
ENSG00000111364 E004 1.796085 0.0108054367 2.779698e-01 0.681259640 12 123602099 123602101 3 + 0.315 0.513 1.082
ENSG00000111364 E005 1.796085 0.0108054367 2.779698e-01 0.681259640 12 123602102 123602102 1 + 0.315 0.513 1.082
ENSG00000111364 E006 9.433613 0.0030655534 4.575631e-01 0.807356997 12 123602103 123602124 22 + 1.053 0.989 -0.235
ENSG00000111364 E007 11.348706 0.0024282370 2.736010e-01 0.677426764 12 123602125 123602127 3 + 1.140 1.048 -0.331
ENSG00000111364 E008 12.423077 0.0073271461 4.526302e-01 0.804900201 12 123602128 123602129 2 + 1.161 1.100 -0.218
ENSG00000111364 E009 24.116467 0.0014157968 1.811157e-01 0.580849745 12 123602130 123602142 13 + 1.436 1.357 -0.275
ENSG00000111364 E010 46.851121 0.0009420603 4.741728e-02 0.337089218 12 123602143 123602256 114 + 1.724 1.637 -0.293
ENSG00000111364 E011 26.101887 0.0857840694 2.310537e-01 0.636039649 12 123603848 123603916 69 + 1.323 1.479 0.540
ENSG00000111364 E012 40.002368 0.0495663389 1.273919e-01 0.506222672 12 123603917 123604038 122 + 1.510 1.660 0.513
ENSG00000111364 E013 96.467700 0.0619436149 1.185122e-01 0.491012542 12 123604873 123605766 894 + 1.899 2.031 0.441
ENSG00000111364 E014 35.931915 0.0310781793 2.215777e-01 0.626096393 12 123605767 123605864 98 + 1.493 1.597 0.356
ENSG00000111364 E015 30.274709 0.0020506886 6.974935e-03 0.147269582 12 123605865 123605930 66 + 1.357 1.553 0.676
ENSG00000111364 E016 66.133886 0.0004990335 2.426518e-01 0.647563442 12 123605931 123605981 51 + 1.841 1.806 -0.117
ENSG00000111364 E017 12.611933 0.0154455915 4.055688e-01 0.777295983 12 123605982 123605994 13 + 1.058 1.155 0.353
ENSG00000111364 E018 17.335782 0.0692429209 3.212452e-01 0.717670736 12 123605995 123606072 78 + 1.167 1.302 0.474
ENSG00000111364 E019 93.027780 0.0003520646 3.826129e-01 0.761919917 12 123606073 123606159 87 + 1.976 1.959 -0.054
ENSG00000111364 E020 137.381980 0.0002310686 9.077567e-02 0.439898973 12 123607432 123607523 92 + 2.152 2.117 -0.117
ENSG00000111364 E021 41.493651 0.0377285628 1.142838e-01 0.482967225 12 123607524 123607599 76 + 1.529 1.675 0.499
ENSG00000111364 E022 74.439033 0.0004359327 7.910895e-02 0.415712903 12 123607600 123607603 4 + 1.899 1.843 -0.190
ENSG00000111364 E023 123.739167 0.0002442616 1.702945e-01 0.567336825 12 123607604 123607662 59 + 2.101 2.074 -0.092
ENSG00000111364 E024 74.936306 0.1109223714 1.041405e-01 0.465035805 12 123607663 123608520 858 + 1.775 1.931 0.525
ENSG00000111364 E025 33.933838 0.1089122297 5.032966e-02 0.345159059 12 123608521 123608679 159 + 1.376 1.619 0.836
ENSG00000111364 E026 204.540248 0.0019462997 7.026241e-01 0.916040091 12 123608680 123608829 150 + 2.302 2.303 0.002
ENSG00000111364 E027 101.926042 0.0058267462 1.857876e-01 0.586535777 12 123609939 123610002 64 + 2.032 1.981 -0.172
ENSG00000111364 E028 150.705939 0.0002714654 5.103372e-01 0.834906174 12 123610003 123610128 126 + 2.172 2.169 -0.011
ENSG00000111364 E029 89.501215 0.0003251095 4.798897e-01 0.819164542 12 123613170 123613214 45 + 1.952 1.942 -0.036
ENSG00000111364 E030 83.046026 0.0003434713 3.879170e-01 0.765737446 12 123613215 123613252 38 + 1.926 1.908 -0.059
ENSG00000111364 E031 10.765572 0.0890156617 9.462564e-01 0.987441460 12 123613253 123613306 54 + 1.047 1.076 0.106
ENSG00000111364 E032 139.526403 0.0049815853 1.862345e-01 0.586982544 12 123615185 123615316 132 + 2.165 2.122 -0.142
ENSG00000111364 E033 92.629848 0.0119150777 1.729032e-01 0.570408337 12 123616511 123616557 47 + 2.004 1.934 -0.237
ENSG00000111364 E034 77.719523 0.0077428593 1.736069e-01 0.571240079 12 123616558 123616603 46 + 1.923 1.860 -0.214
ENSG00000111364 E035 19.959259 0.0014784247 7.417079e-02 0.404620992 12 123617476 123617757 282 + 1.212 1.368 0.544
ENSG00000111364 E036 87.662013 0.0052549740 3.681597e-01 0.752212791 12 123617758 123617872 115 + 1.959 1.930 -0.096
ENSG00000111364 E037 15.095366 0.0088109485 1.994807e-01 0.602734106 12 123617873 123618015 143 + 1.107 1.247 0.497
ENSG00000111364 E038 51.966980 0.0103673170 5.611187e-05 0.009685668 12 123618016 123618610 595 + 1.520 1.812 0.990
ENSG00000111364 E039 32.480543 0.0008593800 7.688659e-04 0.046527804 12 123618611 123618668 58 + 1.369 1.599 0.788
ENSG00000111364 E040 163.991447 0.0003414183 7.597963e-01 0.935799280 12 123618669 123618837 169 + 2.208 2.215 0.023
ENSG00000111364 E041 65.384317 0.0063423620 5.620629e-01 0.858933221 12 123619432 123619447 16 + 1.831 1.811 -0.068
ENSG00000111364 E042 264.468286 0.0026149026 3.812004e-01 0.760981834 12 123619448 123619724 277 + 2.425 2.413 -0.039
ENSG00000111364 E043 467.880908 0.0060054050 8.088000e-01 0.951074014 12 123619964 123620943 980 + 2.661 2.668 0.023