ENSG00000111011

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000331738 ENSG00000111011 HEK293_DMSO_6hA HEK293_OSMI2_6hA RSRC2 protein_coding protein_coding 47.32617 28.33321 36.56587 8.401839 5.633448 0.3678891 3.149741 2.374669 2.363233 0.6567892 0.3208184 -0.006935552 0.07126250 0.08550000 0.0651000 -0.02040000 0.66835525 0.02488703 FALSE TRUE
ENST00000392442 ENSG00000111011 HEK293_DMSO_6hA HEK293_OSMI2_6hA RSRC2 protein_coding processed_transcript 47.32617 28.33321 36.56587 8.401839 5.633448 0.3678891 4.326335 3.106293 3.976066 2.0083930 0.3475414 0.355134814 0.09031250 0.08953333 0.1154000 0.02586667 0.75036562 0.02488703 FALSE TRUE
ENST00000433877 ENSG00000111011 HEK293_DMSO_6hA HEK293_OSMI2_6hA RSRC2 protein_coding nonsense_mediated_decay 47.32617 28.33321 36.56587 8.401839 5.633448 0.3678891 12.025490 7.102741 9.732769 2.0571638 1.9921323 0.453926345 0.25456250 0.25156667 0.2615667 0.01000000 0.88473522 0.02488703 FALSE TRUE
ENST00000527796 ENSG00000111011 HEK293_DMSO_6hA HEK293_OSMI2_6hA RSRC2 protein_coding retained_intron 47.32617 28.33321 36.56587 8.401839 5.633448 0.3678891 3.456145 1.747152 1.435439 0.6976891 0.1644253 -0.281730969 0.06425833 0.05850000 0.0425000 -0.01600000 0.72192136 0.02488703 FALSE FALSE
ENST00000532695 ENSG00000111011 HEK293_DMSO_6hA HEK293_OSMI2_6hA RSRC2 protein_coding nonsense_mediated_decay 47.32617 28.33321 36.56587 8.401839 5.633448 0.3678891 12.669406 8.280523 10.583030 2.0994410 1.7668474 0.353580396 0.28266250 0.29976667 0.2882000 -0.01156667 0.94461210 0.02488703 FALSE TRUE
MSTRG.8221.2 ENSG00000111011 HEK293_DMSO_6hA HEK293_OSMI2_6hA RSRC2 protein_coding   47.32617 28.33321 36.56587 8.401839 5.633448 0.3678891 6.247353 1.263950 5.713716 0.3999466 2.0906657 2.167642950 0.12267500 0.04476667 0.1454333 0.10066667 0.02488703 0.02488703 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000111011 E001 3.695033 0.0099517654 2.583621e-01 0.664018083 12 122503454 122503737 284 - 0.580 0.753 0.737
ENSG00000111011 E002 3.543374 0.0061561228 1.662108e-01 0.562166892 12 122503738 122503846 109 - 0.546 0.754 0.892
ENSG00000111011 E003 5.866328 0.0622898341 2.199237e-01 0.624487593 12 122503847 122504039 193 - 0.952 0.724 -0.889
ENSG00000111011 E004 78.539805 0.0038372328 2.948466e-03 0.097569185 12 122504040 122505058 1019 - 1.826 1.977 0.507
ENSG00000111011 E005 165.391073 0.0002951654 1.763762e-02 0.224163837 12 122505059 122505305 247 - 2.198 2.265 0.223
ENSG00000111011 E006 139.226892 0.0023657962 1.903961e-02 0.230987545 12 122505306 122505329 24 - 2.112 2.199 0.292
ENSG00000111011 E007 152.426497 0.0003055921 1.726799e-01 0.570137474 12 122505330 122505379 50 - 2.176 2.217 0.138
ENSG00000111011 E008 361.605556 0.0027997336 2.794922e-01 0.682913421 12 122505380 122505604 225 - 2.541 2.582 0.135
ENSG00000111011 E009 270.409446 0.0012512602 6.911929e-01 0.912251933 12 122505605 122505706 102 - 2.429 2.445 0.051
ENSG00000111011 E010 7.996377 0.0975619365 9.319218e-03 0.168057279 12 122506372 122506833 462 - 0.676 1.133 1.752
ENSG00000111011 E011 243.410154 0.0013006540 2.877530e-01 0.689724748 12 122506834 122506923 90 - 2.402 2.381 -0.068
ENSG00000111011 E012 5.327191 0.0057960539 4.619286e-06 0.001771892 12 122506924 122507253 330 - 0.380 1.029 2.793
ENSG00000111011 E013 4.310766 0.0054281600 4.673157e-04 0.034632566 12 122507873 122508217 345 - 0.427 0.932 2.171
ENSG00000111011 E014 185.396095 0.0039433925 4.803543e-01 0.819399631 12 122508218 122508249 32 - 2.279 2.267 -0.039
ENSG00000111011 E015 263.824858 0.0001811996 5.604939e-01 0.858234073 12 122508250 122508366 117 - 2.434 2.425 -0.031
ENSG00000111011 E016 109.388550 0.0014340431 3.111789e-01 0.708929454 12 122508367 122508377 11 - 2.071 2.034 -0.121
ENSG00000111011 E017 166.377905 0.0040765496 1.913065e-01 0.593344398 12 122508378 122508447 70 - 2.256 2.200 -0.187
ENSG00000111011 E018 45.798679 0.0076267437 4.014217e-01 0.774289232 12 122508448 122508450 3 - 1.709 1.644 -0.219
ENSG00000111011 E019 87.032921 0.0037947380 2.194690e-01 0.624105547 12 122511109 122511110 2 - 1.981 1.918 -0.211
ENSG00000111011 E020 190.772680 0.0034853233 1.468942e-01 0.534986356 12 122511111 122511188 78 - 2.315 2.259 -0.189
ENSG00000111011 E021 8.867674 0.0046628995 8.186054e-02 0.421653918 12 122513767 122513874 108 - 0.902 1.096 0.719
ENSG00000111011 E022 3.429932 0.3664176948 2.669767e-01 0.671540780 12 122513875 122513917 43 - 0.488 0.771 1.241
ENSG00000111011 E023 1.905651 0.0116908200 6.655954e-01 0.902534608 12 122514712 122514728 17 - 0.427 0.499 0.366
ENSG00000111011 E024 3.648174 0.1075854974 5.893635e-01 0.871056328 12 122514773 122515104 332 - 0.585 0.747 0.691
ENSG00000111011 E025 182.109303 0.0007619157 3.336794e-02 0.291901357 12 122515105 122515162 58 - 2.300 2.240 -0.200
ENSG00000111011 E026 208.854083 0.0002712005 8.996655e-02 0.438496876 12 122515163 122515227 65 - 2.347 2.307 -0.133
ENSG00000111011 E027 129.721404 0.0014090934 9.233951e-02 0.442828276 12 122517227 122517230 4 - 2.149 2.091 -0.193
ENSG00000111011 E028 136.399131 0.0018237184 5.434320e-02 0.356767065 12 122517231 122517235 5 - 2.175 2.106 -0.230
ENSG00000111011 E029 338.885812 0.0012119664 3.657981e-01 0.750735208 12 122517236 122517430 195 - 2.548 2.527 -0.071
ENSG00000111011 E030 121.700472 0.0002975144 4.583669e-01 0.807693751 12 122518839 122518839 1 - 2.110 2.089 -0.071
ENSG00000111011 E031 213.331401 0.0001829805 9.983934e-02 0.457017261 12 122518840 122518929 90 - 2.358 2.321 -0.123
ENSG00000111011 E032 190.338826 0.0001731041 3.862546e-01 0.764699756 12 122518930 122519029 100 - 2.300 2.280 -0.064
ENSG00000111011 E033 26.924523 0.0101693561 3.692123e-02 0.303529415 12 122519030 122519051 22 - 1.349 1.535 0.639
ENSG00000111011 E034 35.955124 0.0213260985 2.934575e-01 0.694265426 12 122519052 122519442 391 - 1.516 1.620 0.356
ENSG00000111011 E035 21.876973 0.0389800630 1.470153e-01 0.535040019 12 122519443 122519664 222 - 1.266 1.448 0.632
ENSG00000111011 E036 28.302447 0.0351808278 1.648457e-01 0.560451755 12 122519665 122519909 245 - 1.370 1.556 0.642
ENSG00000111011 E037 22.898384 0.0189268658 8.854454e-05 0.012617106 12 122519910 122520140 231 - 1.141 1.558 1.453
ENSG00000111011 E038 11.134858 0.0022545776 6.155673e-03 0.139085148 12 122520141 122520201 61 - 0.945 1.216 0.983
ENSG00000111011 E039 19.077356 0.0046810804 6.048983e-06 0.002132704 12 122520202 122520503 302 - 1.085 1.473 1.361
ENSG00000111011 E040 25.313601 0.0276644892 2.540802e-01 0.659801762 12 122520504 122520545 42 - 1.352 1.486 0.463
ENSG00000111011 E041 21.703915 0.0123307382 2.573924e-01 0.663056831 12 122520546 122520581 36 - 1.298 1.410 0.391
ENSG00000111011 E042 22.419363 0.1216669286 2.779030e-01 0.681227785 12 122520582 122520977 396 - 1.282 1.447 0.576
ENSG00000111011 E043 13.440768 0.1225506309 5.728463e-01 0.863496786 12 122520978 122521295 318 - 1.108 1.209 0.358
ENSG00000111011 E044 6.988970 0.0747768508 6.637205e-01 0.901807689 12 122521296 122521384 89 - 0.858 0.946 0.334
ENSG00000111011 E045 109.369943 0.0003117240 7.929415e-02 0.416144218 12 122521385 122521428 44 - 2.078 2.021 -0.191
ENSG00000111011 E046 160.954063 0.0002336265 1.136550e-01 0.481839230 12 122522143 122522299 157 - 2.239 2.198 -0.137
ENSG00000111011 E047 1.345035 0.2545440742 4.295675e-01   12 122522300 122522329 30 - 0.273 0.444 1.028
ENSG00000111011 E048 2.221122 0.1023548087 1.342857e-01 0.516631294 12 122522330 122522442 113 - 0.332 0.627 1.497
ENSG00000111011 E049 1.956328 0.0151669897 2.286305e-01 0.633843962 12 122522799 122522906 108 - 0.379 0.588 1.041
ENSG00000111011 E050 7.831380 0.0073229046 2.674077e-04 0.024522339 12 122522907 122523756 850 - 0.691 1.132 1.683
ENSG00000111011 E051 3.594310 0.1024955803 3.207873e-01 0.717274100 12 122526170 122526293 124 - 0.553 0.751 0.849
ENSG00000111011 E052 101.890312 0.0004158440 2.833033e-01 0.686143088 12 122526848 122527000 153 - 2.039 2.004 -0.118