ENSG00000110987

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261822 ENSG00000110987 HEK293_DMSO_6hA HEK293_OSMI2_6hA BCL7A protein_coding protein_coding 22.43347 20.31467 25.26536 1.01792 1.975572 0.3145 18.889111 16.461167 22.014637 0.7187010 1.7209984 0.4191754 0.8436458 0.8109000 0.8713333 0.06043333 0.02721064 0.02721064 FALSE  
MSTRG.8197.3 ENSG00000110987 HEK293_DMSO_6hA HEK293_OSMI2_6hA BCL7A protein_coding   22.43347 20.31467 25.26536 1.01792 1.975572 0.3145 2.899972 3.246766 2.951548 0.2531907 0.2618072 -0.1370885 0.1284542 0.1593667 0.1166667 -0.04270000 0.29644495 0.02721064 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000110987 E001 1.604059 0.0109575303 0.852808723   12 122019422 122021883 2462 + 0.395 0.430 0.186
ENSG00000110987 E002 12.096231 0.0021717691 0.128439931 0.50787438 12 122021884 122021957 74 + 1.175 1.034 -0.511
ENSG00000110987 E003 31.087753 0.0101112209 0.006078077 0.13836956 12 122021958 122021977 20 + 1.599 1.388 -0.726
ENSG00000110987 E004 142.557437 0.0051451798 0.076542046 0.41034960 12 122021978 122022183 206 + 2.192 2.116 -0.255
ENSG00000110987 E005 139.672488 0.0002648124 0.011155822 0.18273645 12 122030700 122030781 82 + 2.174 2.103 -0.238
ENSG00000110987 E006 171.717992 0.0002049174 0.095100066 0.44836213 12 122035331 122035427 97 + 2.246 2.206 -0.134
ENSG00000110987 E007 229.656020 0.0001907405 0.159808347 0.55410281 12 122043886 122044053 168 + 2.367 2.340 -0.093
ENSG00000110987 E008 1.743473 0.0267805543 0.927680823 0.98285282 12 122044054 122044371 318 + 0.445 0.429 -0.082
ENSG00000110987 E009 194.626517 0.0003195638 0.543077580 0.85141481 12 122054805 122054926 122 + 2.287 2.276 -0.037
ENSG00000110987 E010 27.936917 0.0010807937 0.073410657 0.40307061 12 122054927 122054989 63 + 1.389 1.511 0.422
ENSG00000110987 E011 202.443241 0.0021804407 0.742634817 0.93021044 12 122059092 122059201 110 + 2.306 2.298 -0.029
ENSG00000110987 E012 1197.829937 0.0001194625 0.345803262 0.73595238 12 122059202 122060805 1604 + 3.064 3.076 0.039
ENSG00000110987 E013 901.585346 0.0007657659 0.002159609 0.08275495 12 122060806 122062044 1239 + 2.928 2.972 0.144