ENSG00000110851

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000228437 ENSG00000110851 HEK293_DMSO_6hA HEK293_OSMI2_6hA PRDM4 protein_coding protein_coding 20.82684 12.56785 18.02394 2.040792 3.231377 0.5198298 14.950279 10.8104189 13.611209 1.8686029 2.5084210 0.3320984 0.74254167 0.85756667 0.75353333 -0.10403333 0.0007247318 0.0007247318 FALSE TRUE
ENST00000550659 ENSG00000110851 HEK293_DMSO_6hA HEK293_OSMI2_6hA PRDM4 protein_coding protein_coding 20.82684 12.56785 18.02394 2.040792 3.231377 0.5198298 1.323430 0.3835664 1.465025 0.1918047 0.4681474 1.9060603 0.05797917 0.02893333 0.07616667 0.04723333 0.5377340129 0.0007247318 FALSE TRUE
MSTRG.7957.2 ENSG00000110851 HEK293_DMSO_6hA HEK293_OSMI2_6hA PRDM4 protein_coding   20.82684 12.56785 18.02394 2.040792 3.231377 0.5198298 3.220371 0.6281916 2.065530 0.2413317 0.2844045 1.7014181 0.13779583 0.04666667 0.11713333 0.07046667 0.0919094199 0.0007247318 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000110851 E001 205.3830517 0.0001730018 5.988549e-05 0.0100238 12 107732871 107733333 463 - 2.266 2.363 0.324
ENSG00000110851 E002 472.9136388 0.0004910116 1.702777e-05 0.0044296 12 107733334 107734190 857 - 2.639 2.715 0.253
ENSG00000110851 E003 267.5123551 0.0001326284 3.148894e-01 0.7121720 12 107734191 107734522 332 - 2.420 2.442 0.072
ENSG00000110851 E004 152.0852233 0.0026034868 9.813982e-01 0.9955727 12 107739383 107739551 169 - 2.188 2.184 -0.014
ENSG00000110851 E005 122.1928781 0.0003456436 4.303910e-01 0.7921364 12 107740946 107741065 120 - 2.106 2.081 -0.082
ENSG00000110851 E006 162.9843740 0.0002735297 2.718665e-01 0.6758209 12 107741066 107741260 195 - 2.230 2.201 -0.098
ENSG00000110851 E007 84.2394691 0.0031576993 6.319207e-01 0.8887857 12 107742221 107742248 28 - 1.920 1.946 0.087
ENSG00000110851 E008 130.9802159 0.0005475150 8.977070e-01 0.9755920 12 107742249 107742348 100 - 2.121 2.118 -0.008
ENSG00000110851 E009 5.3541019 0.0966508860 6.315418e-01 0.8886525 12 107742349 107742593 245 - 0.751 0.831 0.316
ENSG00000110851 E010 104.8566294 0.0003454212 9.354673e-01 0.9848185 12 107743197 107743282 86 - 2.023 2.022 -0.006
ENSG00000110851 E011 134.6978433 0.0002596851 1.232670e-01 0.4992797 12 107744543 107744661 119 - 2.152 2.107 -0.153
ENSG00000110851 E012 6.1000806 0.0051511338 1.329257e-01 0.5145515 12 107744662 107744682 21 - 0.944 0.755 -0.732
ENSG00000110851 E013 153.0988821 0.0022295478 1.893030e-01 0.5907696 12 107746275 107746424 150 - 2.206 2.158 -0.160
ENSG00000110851 E014 177.3237095 0.0002731835 1.517803e-01 0.5418676 12 107751415 107751646 232 - 2.268 2.230 -0.125
ENSG00000110851 E015 284.7444902 0.0012198233 4.663824e-01 0.8120334 12 107751647 107752209 563 - 2.468 2.448 -0.065
ENSG00000110851 E016 87.1867724 0.0003744423 3.174378e-01 0.7146760 12 107753924 107754025 102 - 1.962 1.925 -0.122
ENSG00000110851 E017 41.8787978 0.0027355540 7.289107e-01 0.9253336 12 107754026 107754027 2 - 1.638 1.620 -0.060
ENSG00000110851 E018 74.2830690 0.0004065612 1.820060e-01 0.5820136 12 107754028 107754109 82 - 1.899 1.846 -0.179
ENSG00000110851 E019 0.5074389 0.0212167285 4.327413e-01   12 107754829 107754860 32 - 0.107 0.236 1.368
ENSG00000110851 E020 80.8213652 0.0003975649 1.057169e-01 0.4678466 12 107756832 107756965 134 - 1.943 1.881 -0.209
ENSG00000110851 E021 84.9603937 0.0011182266 3.777374e-03 0.1100079 12 107760505 107760771 267 - 1.986 1.868 -0.396
ENSG00000110851 E022 1.1937002 0.1009749824 1.297020e-01   12 107760772 107760928 157 - 0.433 0.134 -2.245
ENSG00000110851 E023 27.1129801 0.0013037656 7.667258e-02 0.4105423 12 107760957 107761130 174 - 1.500 1.381 -0.409
ENSG00000110851 E024 2.5004947 0.0081384793 6.142255e-01 0.8819117 12 107761131 107761274 144 - 0.509 0.589 0.372