ENSG00000110169

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265983 ENSG00000110169 HEK293_DMSO_6hA HEK293_OSMI2_6hA HPX protein_coding protein_coding 0.9470879 1.69592 1.737143 0.2181085 0.6187472 0.03444833 0.18812192 0.3438988 0.19161775 0.12840207 0.07833692 -0.8117141 0.26370417 0.2010333 0.1065667 -0.09446667 0.73754441 0.02277357 FALSE TRUE
ENST00000525057 ENSG00000110169 HEK293_DMSO_6hA HEK293_OSMI2_6hA HPX protein_coding processed_transcript 0.9470879 1.69592 1.737143 0.2181085 0.6187472 0.03444833 0.15760279 0.3333567 0.15743247 0.13142000 0.08032744 -1.0361285 0.18153333 0.1871333 0.1303667 -0.05676667 0.74899234 0.02277357 FALSE TRUE
ENST00000527105 ENSG00000110169 HEK293_DMSO_6hA HEK293_OSMI2_6hA HPX protein_coding processed_transcript 0.9470879 1.69592 1.737143 0.2181085 0.6187472 0.03444833 0.17816733 0.0000000 0.67729020 0.00000000 0.67729020 6.1028475 0.06191667 0.0000000 0.2277000 0.22770000 0.74469894 0.02277357   FALSE
ENST00000527556 ENSG00000110169 HEK293_DMSO_6hA HEK293_OSMI2_6hA HPX protein_coding retained_intron 0.9470879 1.69592 1.737143 0.2181085 0.6187472 0.03444833 0.14765844 0.2891905 0.18734643 0.07966352 0.10104873 -0.6003341 0.18788750 0.1682000 0.1475667 -0.02063333 0.78927590 0.02277357 FALSE FALSE
ENST00000528348 ENSG00000110169 HEK293_DMSO_6hA HEK293_OSMI2_6hA HPX protein_coding retained_intron 0.9470879 1.69592 1.737143 0.2181085 0.6187472 0.03444833 0.06853509 0.1897919 0.07365992 0.02870582 0.05603964 -1.2558898 0.09539167 0.1193333 0.0581000 -0.06123333 0.72236575 0.02277357 FALSE TRUE
ENST00000529775 ENSG00000110169 HEK293_DMSO_6hA HEK293_OSMI2_6hA HPX protein_coding retained_intron 0.9470879 1.69592 1.737143 0.2181085 0.6187472 0.03444833 0.03053657 0.1777913 0.00000000 0.04104987 0.00000000 -4.2310587 0.02467083 0.1039667 0.0000000 -0.10396667 0.02277357 0.02277357 FALSE FALSE
ENST00000533856 ENSG00000110169 HEK293_DMSO_6hA HEK293_OSMI2_6hA HPX protein_coding retained_intron 0.9470879 1.69592 1.737143 0.2181085 0.6187472 0.03444833 0.11952260 0.2322692 0.31613473 0.13167111 0.19991257 0.4288572 0.12801667 0.1374667 0.2671667 0.12970000 0.88057636 0.02277357 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000110169 E001 4.9643278 0.098534610 0.0711160476 0.39795256 11 6431049 6431301 253 - 0.482 0.862 1.624
ENSG00000110169 E002 4.5926996 0.020055874 0.0005254599 0.03710912 11 6431302 6431394 93 - 0.261 0.865 2.944
ENSG00000110169 E003 3.5564596 0.007579322 0.0170852886 0.22099649 11 6431395 6431470 76 - 0.349 0.751 1.909
ENSG00000110169 E004 5.7459167 0.248934236 0.9321919244 0.98385172 11 6431641 6431803 163 - 0.804 0.823 0.075
ENSG00000110169 E005 3.0020377 0.014620903 0.2353229403 0.64017682 11 6431887 6431905 19 - 0.707 0.537 -0.746
ENSG00000110169 E006 3.8641828 0.007136511 0.4447071634 0.80041958 11 6431906 6431949 44 - 0.742 0.645 -0.403
ENSG00000110169 E007 5.1547003 0.004566599 0.3904229924 0.76725113 11 6431950 6432017 68 - 0.830 0.732 -0.392
ENSG00000110169 E008 0.4732995 0.024310079 0.2908986342   11 6432018 6432075 58 - 0.261 0.095 -1.753
ENSG00000110169 E009 0.5403557 0.028169000 0.9794123583   11 6432076 6432319 244 - 0.150 0.173 0.244
ENSG00000110169 E010 0.1767706 0.032492166 0.2775056141   11 6437045 6437045 1 - 0.150 0.000 -10.539
ENSG00000110169 E011 6.2061595 0.004122255 0.2084723323 0.61258644 11 6437046 6437177 132 - 0.925 0.787 -0.532
ENSG00000110169 E012 3.6853743 0.092592109 0.7595722642 0.93571443 11 6437178 6437439 262 - 0.684 0.619 -0.277
ENSG00000110169 E013 4.9075990 0.005390264 0.7984900530 0.94782952 11 6437440 6437624 185 - 0.773 0.751 -0.089
ENSG00000110169 E014 2.9222571 0.007267895 0.8261977289 0.95589966 11 6437625 6437652 28 - 0.589 0.566 -0.102
ENSG00000110169 E015 6.6703747 0.005349846 0.2311292227 0.63615242 11 6437653 6438109 457 - 0.743 0.907 0.640
ENSG00000110169 E016 1.6825846 0.011133563 0.2290927611 0.63423400 11 6438334 6438351 18 - 0.540 0.346 -1.017
ENSG00000110169 E017 0.9978121 0.023166885 0.7394391523   11 6438352 6438355 4 - 0.348 0.296 -0.331
ENSG00000110169 E018 2.3304545 0.008545155 0.4216533120 0.78710434 11 6438356 6438478 123 - 0.589 0.470 -0.560
ENSG00000110169 E019 0.7896109 0.272431385 0.1455712125   11 6438479 6438509 31 - 0.000 0.342 11.155
ENSG00000110169 E020 4.2062257 0.010027470 0.1855665151 0.58623699 11 6439609 6440164 556 - 0.541 0.752 0.910
ENSG00000110169 E021 4.7327868 0.004860534 0.5766376138 0.86522793 11 6440165 6440286 122 - 0.774 0.712 -0.253
ENSG00000110169 E022 2.4996542 0.013815677 0.1859766482 0.58677490 11 6440467 6440485 19 - 0.634 0.433 -0.951
ENSG00000110169 E023 3.2544362 0.021562830 0.0385505096 0.30920457 11 6440486 6440538 53 - 0.775 0.470 -1.344
ENSG00000110169 E024 3.1525265 0.026549669 0.1628612951 0.55762924 11 6440672 6440724 53 - 0.711 0.505 -0.911
ENSG00000110169 E025 1.8903056 0.015906728 0.5394144029 0.84952797 11 6440725 6440730 6 - 0.486 0.392 -0.493
ENSG00000110169 E026 1.3527521 0.015539250 0.9477153829   11 6440731 6440739 9 - 0.349 0.347 -0.017
ENSG00000110169 E027 2.9782046 0.149014118 0.6865167103 0.91053241 11 6440834 6440880 47 - 0.487 0.622 0.626
ENSG00000110169 E028 2.9580948 0.108266712 0.9344302545 0.98464682 11 6440881 6441066 186 - 0.543 0.594 0.233
ENSG00000110169 E029 2.6475626 0.009712561 0.9264286857 0.98258325 11 6441446 6441635 190 - 0.541 0.536 -0.022
ENSG00000110169 E030 2.5811958 0.121897851 0.4561770899 0.80672603 11 6442487 6442617 131 - 0.426 0.590 0.795