ENSG00000108559

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000574087 ENSG00000108559 HEK293_DMSO_6hA HEK293_OSMI2_6hA NUP88 protein_coding retained_intron 55.21346 21.62422 21.06392 5.265445 2.809258 -0.03785647 4.265479 3.577315 2.055331 0.8428816 0.2862153 -0.7965313 0.0941375 0.1664000 0.09763333 -0.06876667 0.03415891 0.03415891 FALSE  
ENST00000574855 ENSG00000108559 HEK293_DMSO_6hA HEK293_OSMI2_6hA NUP88 protein_coding retained_intron 55.21346 21.62422 21.06392 5.265445 2.809258 -0.03785647 18.304018 6.886382 7.487366 1.6115818 1.1102541 0.1205441 0.3378583 0.3195000 0.35653333 0.03703333 0.75116649 0.03415891 FALSE  
MSTRG.13507.11 ENSG00000108559 HEK293_DMSO_6hA HEK293_OSMI2_6hA NUP88 protein_coding   55.21346 21.62422 21.06392 5.265445 2.809258 -0.03785647 16.554639 3.797392 6.232050 1.5300922 1.3243258 0.7132167 0.2811833 0.1615000 0.28916667 0.12766667 0.25156200 0.03415891 FALSE  
MSTRG.13507.5 ENSG00000108559 HEK293_DMSO_6hA HEK293_OSMI2_6hA NUP88 protein_coding   55.21346 21.62422 21.06392 5.265445 2.809258 -0.03785647 8.285121 2.480250 1.848846 1.0318441 0.5218747 -0.4218836 0.1365375 0.1136667 0.08646667 -0.02720000 0.84372405 0.03415891 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000108559 E001 1.2773580 0.4698423402 0.388584286   17 5360963 5361813 851 - 0.203 0.469 1.709
ENSG00000108559 E002 0.6512351 0.5550344023 0.543101320   17 5361814 5362086 273 - 0.115 0.296 1.683
ENSG00000108559 E003 19.6655081 0.0415678788 0.122422346 0.49790040 17 5384833 5386089 1257 - 1.209 1.393 0.641
ENSG00000108559 E004 1.9441773 0.5608386090 0.661644010 0.90109604 17 5386090 5386101 12 - 0.464 0.505 0.203
ENSG00000108559 E005 2.1860424 0.6619798429 0.683326959 0.90951365 17 5386102 5386103 2 - 0.497 0.540 0.204
ENSG00000108559 E006 2.7619410 0.8072986549 0.612987021 0.88135634 17 5386104 5386112 9 - 0.527 0.639 0.504
ENSG00000108559 E007 7.6459134 0.0331886239 0.884832437 0.97248360 17 5386113 5386137 25 - 0.942 0.963 0.078
ENSG00000108559 E008 70.2216482 0.0004505382 0.487093275 0.82294664 17 5386138 5386269 132 - 1.837 1.867 0.099
ENSG00000108559 E009 1.4894907 0.0123295645 0.014522798   17 5386613 5386625 13 - 0.120 0.549 3.001
ENSG00000108559 E010 1.9600489 0.3835362694 0.339729044 0.73163290 17 5386626 5386686 61 - 0.293 0.584 1.561
ENSG00000108559 E011 1.6416247 0.1229451347 0.272824426 0.67667383 17 5386687 5386703 17 - 0.291 0.508 1.218
ENSG00000108559 E012 15.2035367 0.0060442776 0.528613364 0.84430356 17 5386704 5386707 4 - 1.182 1.235 0.187
ENSG00000108559 E013 117.1408308 0.0003356372 0.486342935 0.82263825 17 5386708 5386826 119 - 2.059 2.081 0.076
ENSG00000108559 E014 110.5921485 0.0003212513 0.448964601 0.80305412 17 5386984 5387069 86 - 2.035 2.060 0.084
ENSG00000108559 E015 67.8034537 0.0004575851 0.598096101 0.87486050 17 5387070 5387083 14 - 1.829 1.852 0.076
ENSG00000108559 E016 56.7032204 0.0005951499 0.485042054 0.82213560 17 5387084 5387089 6 - 1.746 1.778 0.107
ENSG00000108559 E017 66.0946226 0.0005151706 0.185307271 0.58592924 17 5387090 5387110 21 - 1.798 1.854 0.189
ENSG00000108559 E018 3.6055799 0.0178554570 0.003062317 0.09955926 17 5387111 5387132 22 - 0.355 0.827 2.174
ENSG00000108559 E019 111.1276041 0.0008304870 0.250699997 0.65651605 17 5387386 5387466 81 - 2.030 2.070 0.135
ENSG00000108559 E020 3.8890208 0.2626799261 0.270041508 0.67436664 17 5387467 5387543 77 - 0.531 0.780 1.069
ENSG00000108559 E021 2.0242419 0.1039215163 0.351822673 0.74090291 17 5387544 5387604 61 - 0.362 0.547 0.958
ENSG00000108559 E022 97.8173169 0.0005951406 0.393336425 0.76901214 17 5387605 5387670 66 - 1.983 2.014 0.104
ENSG00000108559 E023 89.7700869 0.0060464189 0.305264717 0.70418474 17 5387779 5387904 126 - 1.986 1.937 -0.165
ENSG00000108559 E024 1.5996806 0.1828443610 0.594036117   17 5387905 5387952 48 - 0.354 0.464 0.603
ENSG00000108559 E025 5.4378565 0.0364847054 0.021606430 0.24341824 17 5387953 5388250 298 - 0.587 0.935 1.411
ENSG00000108559 E026 15.4355186 0.0859440260 0.433640700 0.79372028 17 5388376 5388801 426 - 1.147 1.255 0.384
ENSG00000108559 E027 108.2018404 0.0003325422 0.092721203 0.44336602 17 5388802 5388960 159 - 2.071 2.016 -0.185
ENSG00000108559 E028 2.0662794 0.0113412076 0.404444336 0.77650077 17 5391475 5391560 86 - 0.412 0.549 0.684
ENSG00000108559 E029 102.0054749 0.0003493787 0.620426807 0.88425281 17 5391561 5391662 102 - 2.005 2.022 0.060
ENSG00000108559 E030 86.2614442 0.0003812419 0.379973886 0.76014502 17 5394891 5394981 91 - 1.924 1.958 0.113
ENSG00000108559 E031 87.1842462 0.0004113048 0.796535137 0.94709643 17 5399552 5399650 99 - 1.950 1.941 -0.030
ENSG00000108559 E032 94.8553321 0.0003107355 0.572284711 0.86317710 17 5404099 5404246 148 - 1.994 1.974 -0.065
ENSG00000108559 E033 117.4583781 0.0026698589 0.344421897 0.73516081 17 5405057 5405243 187 - 2.091 2.051 -0.136
ENSG00000108559 E034 40.6313192 0.0091718994 0.274160195 0.67805158 17 5408733 5408736 4 - 1.656 1.573 -0.281
ENSG00000108559 E035 110.3032059 0.0005416329 0.185521017 0.58617675 17 5408737 5408909 173 - 2.069 2.024 -0.152
ENSG00000108559 E036 74.1206642 0.0004452787 0.310277434 0.70832312 17 5410703 5410789 87 - 1.902 1.861 -0.137
ENSG00000108559 E037 70.1682389 0.0004012418 0.855669869 0.96444438 17 5414009 5414099 91 - 1.859 1.852 -0.024
ENSG00000108559 E038 36.8600102 0.0141372748 0.871810270 0.96868987 17 5414100 5414134 35 - 1.591 1.570 -0.070
ENSG00000108559 E039 38.8835079 0.0034191093 0.683357983 0.90953016 17 5416513 5416552 40 - 1.618 1.588 -0.101
ENSG00000108559 E040 53.6524710 0.0007072372 0.077617727 0.41276162 17 5416553 5416682 130 - 1.786 1.703 -0.281
ENSG00000108559 E041 0.8106075 0.0934233057 0.197993321   17 5418015 5418116 102 - 0.358 0.119 -2.017
ENSG00000108559 E042 0.5436302 0.7129920311 0.308507609   17 5418117 5418141 25 - 0.310 0.000 -11.848
ENSG00000108559 E043 0.3089214 0.0656640663 0.217107366   17 5418142 5418229 88 - 0.000 0.213 10.962
ENSG00000108559 E044 67.5282246 0.0045580329 0.072418463 0.40104052 17 5419354 5419746 393 - 1.888 1.793 -0.320