ENSG00000108515

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000323997 ENSG00000108515 HEK293_DMSO_6hA HEK293_OSMI2_6hA ENO3 protein_coding protein_coding 4.060262 6.317708 4.785728 0.331193 0.965369 -0.3999332 0.2726270 0.3742545 0.4663050 0.13061896 0.21121385 0.3098233 0.07099583 0.05796667 0.1190667 0.061100000 0.7811166564 0.0003975578 FALSE  
ENST00000521659 ENSG00000108515 HEK293_DMSO_6hA HEK293_OSMI2_6hA ENO3 protein_coding nonsense_mediated_decay 4.060262 6.317708 4.785728 0.331193 0.965369 -0.3999332 0.4895936 0.7243139 0.5141376 0.06118140 0.14802918 -0.4864512 0.12257083 0.11623333 0.1040000 -0.012233333 0.9487428074 0.0003975578 FALSE  
ENST00000521811 ENSG00000108515 HEK293_DMSO_6hA HEK293_OSMI2_6hA ENO3 protein_coding protein_coding 4.060262 6.317708 4.785728 0.331193 0.965369 -0.3999332 0.3566600 0.7193479 0.4780629 0.14315863 0.04505671 -0.5795399 0.08954167 0.11576667 0.1056333 -0.010133333 0.9541890295 0.0003975578 FALSE  
ENST00000522301 ENSG00000108515 HEK293_DMSO_6hA HEK293_OSMI2_6hA ENO3 protein_coding protein_coding 4.060262 6.317708 4.785728 0.331193 0.965369 -0.3999332 0.1699965 0.5150970 0.0000000 0.14575959 0.00000000 -5.7145121 0.04305000 0.07980000 0.0000000 -0.079800000 0.0003975578 0.0003975578 FALSE  
ENST00000522425 ENSG00000108515 HEK293_DMSO_6hA HEK293_OSMI2_6hA ENO3 protein_coding retained_intron 4.060262 6.317708 4.785728 0.331193 0.965369 -0.3999332 1.1493251 1.8996722 1.4375395 0.11009519 0.51560617 -0.3997223 0.28128750 0.30146667 0.2830000 -0.018466667 0.9426304426 0.0003975578 FALSE  
ENST00000522798 ENSG00000108515 HEK293_DMSO_6hA HEK293_OSMI2_6hA ENO3 protein_coding protein_coding 4.060262 6.317708 4.785728 0.331193 0.965369 -0.3999332 0.3224186 0.1760039 0.3257042 0.03494079 0.11244915 0.8518577 0.08207500 0.02810000 0.0737000 0.045600000 0.6613606595 0.0003975578 FALSE  
MSTRG.13485.4 ENSG00000108515 HEK293_DMSO_6hA HEK293_OSMI2_6hA ENO3 protein_coding   4.060262 6.317708 4.785728 0.331193 0.965369 -0.3999332 0.3875487 0.6817582 0.5512953 0.10416701 0.18396081 -0.3015077 0.09265417 0.10743333 0.1098667 0.002433333 0.9801913499 0.0003975578 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000108515 E001 1.2173235 0.0151301716 5.294063e-01   17 4948092 4948251 160 + 0.382 0.269 -0.720
ENSG00000108515 E002 12.1784161 0.0028843657 3.218838e-05 0.006617748 17 4948252 4948347 96 + 1.294 0.895 -1.444
ENSG00000108515 E003 24.5106076 0.0242841603 5.967240e-03 0.137132412 17 4948348 4948373 26 + 1.531 1.274 -0.889
ENSG00000108515 E004 2.3698301 0.0085378504 7.090527e-01 0.918374517 17 4949177 4949293 117 + 0.540 0.477 -0.303
ENSG00000108515 E005 3.3466457 0.0072292438 1.272895e-01 0.506069834 17 4950072 4950189 118 + 0.493 0.723 1.023
ENSG00000108515 E006 20.4836561 0.0305375649 8.717415e-02 0.432397687 17 4950190 4950630 441 + 1.219 1.391 0.599
ENSG00000108515 E007 4.2905496 0.0057825767 2.025812e-01 0.606367890 17 4951080 4951094 15 + 0.798 0.617 -0.749
ENSG00000108515 E008 5.8461733 0.0043824425 5.578465e-01 0.857195786 17 4951095 4951118 24 + 0.865 0.788 -0.301
ENSG00000108515 E009 6.6703993 0.0049737106 8.882250e-01 0.973265060 17 4951119 4951140 22 + 0.866 0.879 0.053
ENSG00000108515 E010 8.7188301 0.0147410654 8.762389e-01 0.970310851 17 4951141 4951182 42 + 0.992 0.968 -0.091
ENSG00000108515 E011 5.0188571 0.0115290428 7.399338e-01 0.929109847 17 4951183 4951214 32 + 0.747 0.788 0.165
ENSG00000108515 E012 4.6181820 0.0050164520 2.820251e-01 0.685104008 17 4951215 4951224 10 + 0.821 0.673 -0.600
ENSG00000108515 E013 3.9561095 0.0077618999 4.667762e-01 0.812201588 17 4951721 4951757 37 + 0.620 0.723 0.437
ENSG00000108515 E014 5.0089675 0.0048861415 3.634337e-01 0.749239732 17 4951758 4951827 70 + 0.688 0.808 0.488
ENSG00000108515 E015 14.0764702 0.0081957443 4.254644e-01 0.789504725 17 4951828 4951914 87 + 1.125 1.200 0.269
ENSG00000108515 E016 3.4263606 0.0297563456 3.186135e-01 0.715570057 17 4951915 4952024 110 + 0.539 0.699 0.702
ENSG00000108515 E017 3.4811336 0.2265275862 9.012854e-01 0.976578675 17 4952025 4952147 123 + 0.670 0.617 -0.229
ENSG00000108515 E018 1.5049734 0.0229302578 5.536681e-01   17 4952148 4952347 200 + 0.442 0.331 -0.626
ENSG00000108515 E019 14.6569480 0.0070069785 2.306408e-01 0.635599988 17 4952795 4952890 96 + 1.251 1.142 -0.389
ENSG00000108515 E020 0.9718594 0.0150896367 8.136194e-01   17 4952891 4953050 160 + 0.313 0.269 -0.300
ENSG00000108515 E021 8.9867657 0.0202721710 3.093973e-01 0.707603217 17 4953051 4953109 59 + 1.061 0.941 -0.440
ENSG00000108515 E022 1.3746474 0.0155492684 2.494136e-01   17 4953110 4953202 93 + 0.232 0.434 1.284
ENSG00000108515 E023 16.6422825 0.0017979502 9.409678e-01 0.986185885 17 4953272 4953341 70 + 1.235 1.238 0.010
ENSG00000108515 E024 22.0493037 0.0014949024 4.614094e-01 0.809285606 17 4953712 4953845 134 + 1.323 1.373 0.172
ENSG00000108515 E025 2.8966039 0.0668007975 7.018218e-01 0.915724302 17 4953846 4954225 380 + 0.622 0.552 -0.313
ENSG00000108515 E026 29.6413593 0.0009883217 9.891319e-01 0.997317034 17 4955075 4955297 223 + 1.475 1.471 -0.014
ENSG00000108515 E027 19.8571874 0.0079211611 4.432438e-01 0.799493759 17 4955407 4955604 198 + 1.265 1.328 0.222
ENSG00000108515 E028 13.8342129 0.0021518485 5.124296e-02 0.347509799 17 4955605 4955799 195 + 1.049 1.223 0.623
ENSG00000108515 E029 11.1268622 0.0029711596 1.063441e-01 0.468791208 17 4955800 4955941 142 + 0.975 1.133 0.574
ENSG00000108515 E030 27.0461155 0.0175834861 9.852534e-01 0.996371065 17 4955942 4956143 202 + 1.448 1.422 -0.091
ENSG00000108515 E031 2.9318474 0.0075932087 6.030512e-01 0.876972893 17 4956167 4956572 406 + 0.540 0.617 0.351
ENSG00000108515 E032 24.0040083 0.0011790762 5.910300e-01 0.871910810 17 4956573 4956681 109 + 1.365 1.398 0.114
ENSG00000108515 E033 15.9610236 0.0018064721 6.000538e-01 0.875517657 17 4956831 4956889 59 + 1.198 1.238 0.142
ENSG00000108515 E034 12.7536193 0.0024439465 3.507977e-01 0.740119685 17 4956978 4957131 154 + 1.076 1.159 0.301