ENSG00000108424

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000290158 ENSG00000108424 HEK293_DMSO_6hA HEK293_OSMI2_6hA KPNB1 protein_coding protein_coding 281.1559 129.3827 175.6276 16.33508 40.52672 0.4408451 24.92184 19.409580 18.507864 2.203578 4.983051 -0.06859429 0.10339583 0.15076667 0.10470000 -0.046066667 0.104172084 0.001631441 FALSE TRUE
ENST00000577875 ENSG00000108424 HEK293_DMSO_6hA HEK293_OSMI2_6hA KPNB1 protein_coding protein_coding 281.1559 129.3827 175.6276 16.33508 40.52672 0.4408451 21.18567 11.621916 5.854748 1.417417 1.306584 -0.98794778 0.06872083 0.09266667 0.03500000 -0.057666667 0.006473780 0.001631441 FALSE FALSE
ENST00000577918 ENSG00000108424 HEK293_DMSO_6hA HEK293_OSMI2_6hA KPNB1 protein_coding processed_transcript 281.1559 129.3827 175.6276 16.33508 40.52672 0.4408451 46.10622 9.201340 27.247018 3.212891 5.639599 1.56514482 0.14178333 0.06750000 0.15803333 0.090533333 0.001631441 0.001631441 FALSE TRUE
ENST00000579901 ENSG00000108424 HEK293_DMSO_6hA HEK293_OSMI2_6hA KPNB1 protein_coding processed_transcript 281.1559 129.3827 175.6276 16.33508 40.52672 0.4408451 20.48981 5.060135 4.575892 3.063037 2.429436 -0.14482174 0.05695000 0.04246667 0.02106667 -0.021400000 0.979880736 0.001631441 FALSE FALSE
ENST00000677341 ENSG00000108424 HEK293_DMSO_6hA HEK293_OSMI2_6hA KPNB1 protein_coding retained_intron 281.1559 129.3827 175.6276 16.33508 40.52672 0.4408451 13.34480 11.153652 13.767249 3.537218 6.838402 0.30347874 0.07470000 0.08570000 0.06663333 -0.019066667 0.770728836 0.001631441 FALSE TRUE
MSTRG.14561.14 ENSG00000108424 HEK293_DMSO_6hA HEK293_OSMI2_6hA KPNB1 protein_coding   281.1559 129.3827 175.6276 16.33508 40.52672 0.4408451 72.94342 31.425513 50.571563 3.577270 11.436855 0.68621631 0.25769167 0.24400000 0.28846667 0.044466667 0.299874348 0.001631441 FALSE TRUE
MSTRG.14561.5 ENSG00000108424 HEK293_DMSO_6hA HEK293_OSMI2_6hA KPNB1 protein_coding   281.1559 129.3827 175.6276 16.33508 40.52672 0.4408451 30.83730 18.777995 25.581912 4.091525 6.845320 0.44587682 0.11498333 0.14323333 0.14210000 -0.001133333 1.000000000 0.001631441 FALSE TRUE
MSTRG.14561.6 ENSG00000108424 HEK293_DMSO_6hA HEK293_OSMI2_6hA KPNB1 protein_coding   281.1559 129.3827 175.6276 16.33508 40.52672 0.4408451 33.43762 10.783280 21.530999 1.475437 3.876906 0.99695181 0.11990417 0.08313333 0.12720000 0.044066667 0.027650926 0.001631441 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000108424 E001 0.8871666 6.798277e-01 9.614331e-01   17 47649476 47649494 19 + 0.288 0.232 -0.412
ENSG00000108424 E002 20.0577945 1.438238e-03 5.571160e-01 0.856937182 17 47649495 47649877 383 + 1.340 1.307 -0.116
ENSG00000108424 E003 17.3817083 2.406633e-03 9.396077e-01 0.985808255 17 47649919 47649924 6 + 1.272 1.276 0.014
ENSG00000108424 E004 39.8583094 3.232861e-03 4.390501e-01 0.797101333 17 47649925 47649937 13 + 1.633 1.597 -0.121
ENSG00000108424 E005 45.0404235 9.214708e-03 7.167489e-01 0.920915359 17 47649938 47649942 5 + 1.674 1.661 -0.044
ENSG00000108424 E006 109.4419653 1.640434e-02 7.178797e-01 0.921414865 17 47649943 47650003 61 + 2.022 2.066 0.147
ENSG00000108424 E007 117.1555389 1.152393e-02 8.764349e-01 0.970329823 17 47650004 47650102 99 + 2.060 2.086 0.087
ENSG00000108424 E008 40.6118562 1.138470e-02 3.141482e-01 0.711542811 17 47650103 47650151 49 + 1.649 1.586 -0.213
ENSG00000108424 E009 51.6201377 6.867413e-03 2.737723e-01 0.677621320 17 47650152 47650177 26 + 1.746 1.682 -0.217
ENSG00000108424 E010 106.6380826 3.638320e-04 1.164822e-02 0.186495172 17 47650178 47650215 38 + 2.070 1.993 -0.257
ENSG00000108424 E011 192.8665674 1.767332e-03 1.551611e-02 0.211914572 17 47650216 47650284 69 + 2.318 2.253 -0.218
ENSG00000108424 E012 0.8014073 2.869361e-01 8.150276e-01   17 47650358 47650385 28 + 0.315 0.232 -0.592
ENSG00000108424 E013 277.8157306 3.847411e-04 5.512946e-04 0.038271672 17 47650386 47650444 59 + 2.476 2.409 -0.224
ENSG00000108424 E014 8.7111639 4.371490e-02 3.539300e-01 0.742444309 17 47651196 47651376 181 + 0.920 1.071 0.558
ENSG00000108424 E015 702.1941121 1.927767e-04 8.227759e-04 0.048371126 17 47652694 47652876 183 + 2.864 2.827 -0.124
ENSG00000108424 E016 571.6527675 1.001810e-04 1.131785e-02 0.183978885 17 47656860 47656924 65 + 2.769 2.742 -0.089
ENSG00000108424 E017 897.3444931 1.019832e-03 2.527022e-01 0.658533849 17 47656925 47657060 136 + 2.957 2.949 -0.027
ENSG00000108424 E018 939.6144008 1.903112e-03 1.750647e-01 0.572874658 17 47658508 47658660 153 + 2.982 2.964 -0.059
ENSG00000108424 E019 2.3861898 8.287451e-03 1.353388e-02 0.200159010 17 47660882 47660904 23 + 0.270 0.686 2.164
ENSG00000108424 E020 2.5529556 8.278229e-03 1.107945e-03 0.057355962 17 47660905 47660935 31 + 0.197 0.745 2.991
ENSG00000108424 E021 6.6663498 1.150643e-01 8.746190e-02 0.433111903 17 47660936 47661118 183 + 0.685 1.021 1.304
ENSG00000108424 E022 596.9688861 8.817464e-04 4.710247e-03 0.123034414 17 47661119 47661178 60 + 2.797 2.751 -0.153
ENSG00000108424 E023 2.1429259 3.402008e-02 1.180700e-01 0.490148572 17 47662169 47662238 70 + 0.332 0.618 1.456
ENSG00000108424 E024 2.3655390 1.062751e+00 5.017016e-01 0.830490486 17 47662550 47662650 101 + 0.470 0.574 0.495
ENSG00000108424 E025 649.1664544 8.018391e-05 8.172437e-02 0.421279879 17 47663089 47663178 90 + 2.819 2.805 -0.044
ENSG00000108424 E026 757.9013969 8.275870e-05 3.887197e-02 0.310116784 17 47664159 47664269 111 + 2.888 2.872 -0.053
ENSG00000108424 E027 371.7795052 7.865659e-04 2.629011e-01 0.667960927 17 47665057 47665060 4 + 2.578 2.564 -0.047
ENSG00000108424 E028 764.6504262 7.821698e-05 4.962494e-03 0.126446932 17 47665061 47665158 98 + 2.897 2.871 -0.085
ENSG00000108424 E029 1003.6543041 4.989974e-04 1.666213e-01 0.562709122 17 47668186 47668364 179 + 3.007 2.998 -0.030
ENSG00000108424 E030 557.7026953 9.296500e-04 2.737127e-01 0.677516154 17 47668365 47668410 46 + 2.754 2.742 -0.040
ENSG00000108424 E031 4.5620028 3.182017e-02 2.472635e-02 0.257530049 17 47668411 47668801 391 + 0.521 0.885 1.523
ENSG00000108424 E032 4.9379467 6.075208e-03 4.585613e-01 0.807790175 17 47669573 47669677 105 + 0.809 0.717 -0.371
ENSG00000108424 E033 972.0200017 2.496548e-04 1.525682e-01 0.542808656 17 47669678 47669869 192 + 2.993 2.985 -0.028
ENSG00000108424 E034 1.2807808 1.995038e-02 3.589759e-01   17 47670324 47670343 20 + 0.270 0.440 1.026
ENSG00000108424 E035 1.9649903 4.216811e-02 4.466257e-01 0.801684402 17 47670377 47670457 81 + 0.388 0.538 0.763
ENSG00000108424 E036 816.4857822 1.173324e-03 3.018595e-01 0.701392424 17 47670702 47670832 131 + 2.919 2.904 -0.051
ENSG00000108424 E037 0.8386702 1.898429e-02 5.312116e-01   17 47671710 47671862 153 + 0.197 0.312 0.872
ENSG00000108424 E038 775.7737260 1.098207e-03 7.111809e-01 0.919193132 17 47673018 47673088 71 + 2.891 2.889 -0.004
ENSG00000108424 E039 848.2714391 4.667356e-04 1.847622e-01 0.585284215 17 47673089 47673165 77 + 2.934 2.922 -0.040
ENSG00000108424 E040 931.6947070 2.984340e-04 2.361527e-01 0.641077068 17 47673490 47673561 72 + 2.973 2.966 -0.023
ENSG00000108424 E041 2.2144216 9.368294e-03 2.459344e-02 0.256925670 17 47673562 47673839 278 + 0.270 0.654 2.026
ENSG00000108424 E042 1208.3950698 5.925323e-05 8.756305e-02 0.433323782 17 47674638 47674782 145 + 3.085 3.079 -0.022
ENSG00000108424 E043 20.9174068 1.985873e-01 8.738962e-02 0.432909237 17 47675714 47676076 363 + 1.143 1.482 1.185
ENSG00000108424 E044 22.1861993 9.722770e-02 1.688139e-02 0.219921211 17 47676077 47676408 332 + 1.120 1.529 1.428
ENSG00000108424 E045 886.2526580 1.108375e-04 2.086904e-01 0.612807201 17 47676409 47676491 83 + 2.949 2.945 -0.016
ENSG00000108424 E046 860.3965757 6.605610e-05 1.067619e-02 0.178917881 17 47677020 47677127 108 + 2.945 2.924 -0.067
ENSG00000108424 E047 1042.5988580 6.798730e-05 1.325804e-01 0.514110601 17 47678046 47678189 144 + 3.020 3.015 -0.019
ENSG00000108424 E048 1075.5111975 6.464829e-05 3.766612e-01 0.757738150 17 47678308 47678413 106 + 3.021 3.042 0.071
ENSG00000108424 E049 144.9623416 1.170310e-01 3.052969e-02 0.281558545 17 47678414 47680019 1606 + 1.954 2.315 1.208
ENSG00000108424 E050 1261.2666635 6.933103e-05 9.977848e-02 0.456871855 17 47680020 47680134 115 + 3.087 3.115 0.095
ENSG00000108424 E051 1351.0014720 6.824334e-05 5.196577e-01 0.839987633 17 47680508 47680602 95 + 3.121 3.139 0.059
ENSG00000108424 E052 1152.7033220 7.360859e-05 6.125294e-01 0.881163545 17 47680603 47680669 67 + 3.054 3.070 0.056
ENSG00000108424 E053 2183.7343935 2.269999e-04 4.514964e-01 0.804343789 17 47682404 47682790 387 + 3.331 3.348 0.058
ENSG00000108424 E054 3592.8938949 9.319283e-04 5.395794e-05 0.009461710 17 47682791 47684312 1522 + 3.522 3.588 0.221
ENSG00000108424 E055 651.5323670 5.852734e-03 1.873373e-05 0.004675222 17 47684313 47685505 1193 + 2.718 2.898 0.600