ENSG00000108344

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264639 ENSG00000108344 HEK293_DMSO_6hA HEK293_OSMI2_6hA PSMD3 protein_coding protein_coding 167.1625 154.0288 225.6188 18.33385 33.1643 0.5506577 154.1491 137.1921 218.3085 15.59857 35.0838 0.6701325 0.9258708 0.892 0.9627667 0.07076667 0.02401813 0.02401813 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000108344 E001 6.904953 5.553948e-03 1.866488e-01 5.875610e-01 17 39980777 39980806 30 + 0.950 0.790 -0.616
ENSG00000108344 E002 134.856219 5.322217e-04 3.616537e-03 1.083724e-01 17 39980807 39980835 29 + 2.172 2.080 -0.310
ENSG00000108344 E003 964.506609 4.718124e-04 1.733132e-06 8.702897e-04 17 39980836 39981090 255 + 3.011 2.942 -0.230
ENSG00000108344 E004 812.795545 4.432828e-04 8.131061e-10 2.495167e-06 17 39981091 39981190 100 + 2.950 2.853 -0.324
ENSG00000108344 E005 1274.705886 7.790004e-05 2.338826e-04 2.248054e-02 17 39984294 39984458 165 + 3.120 3.082 -0.124
ENSG00000108344 E006 779.337883 7.568204e-05 1.027197e-01 4.622792e-01 17 39984459 39984484 26 + 2.897 2.877 -0.066
ENSG00000108344 E007 928.376207 7.617147e-05 2.736123e-01 6.774382e-01 17 39986575 39986608 34 + 2.970 2.958 -0.040
ENSG00000108344 E008 1240.883621 7.037232e-05 3.374819e-01 7.300659e-01 17 39986609 39986683 75 + 3.094 3.085 -0.030
ENSG00000108344 E009 952.751505 6.097999e-05 4.413718e-01 7.984252e-01 17 39986684 39986712 29 + 2.979 2.971 -0.027
ENSG00000108344 E010 1539.485126 2.497120e-04 5.709444e-02 3.639850e-01 17 39988683 39988819 137 + 3.193 3.174 -0.064
ENSG00000108344 E011 1096.868103 6.850490e-04 8.999374e-01 9.761392e-01 17 39989739 39989793 55 + 3.037 3.039 0.009
ENSG00000108344 E012 1721.610670 9.064148e-05 4.699625e-01 8.138864e-01 17 39989794 39989929 136 + 3.235 3.230 -0.016
ENSG00000108344 E013 43.063805 5.520774e-02 1.022889e-02 1.753706e-01 17 39989930 39990093 164 + 1.473 1.783 1.055
ENSG00000108344 E014 1758.997889 5.282141e-05 3.115581e-01 7.093296e-01 17 39990094 39990197 104 + 3.245 3.237 -0.024
ENSG00000108344 E015 109.185830 1.534768e-01 2.246581e-02 2.476740e-01 17 39992998 39994953 1956 + 1.833 2.203 1.241
ENSG00000108344 E016 1870.436735 4.682280e-04 2.883355e-01 6.901600e-01 17 39994954 39995068 115 + 3.273 3.264 -0.029
ENSG00000108344 E017 1166.887596 1.489381e-04 5.250766e-01 8.426273e-01 17 39995176 39995196 21 + 3.066 3.061 -0.018
ENSG00000108344 E018 1866.447239 2.233904e-04 6.230618e-01 8.853659e-01 17 39995197 39995295 99 + 3.264 3.273 0.030
ENSG00000108344 E019 1938.960536 4.556208e-05 7.252278e-01 9.240660e-01 17 39995424 39995527 104 + 3.285 3.283 -0.006
ENSG00000108344 E020 91.480635 8.412543e-02 4.842188e-02 3.400840e-01 17 39995528 39996120 593 + 1.828 2.084 0.860
ENSG00000108344 E021 2727.056834 6.139790e-05 1.850668e-04 1.945890e-02 17 39996183 39996338 156 + 3.418 3.448 0.098
ENSG00000108344 E022 20.042157 6.587069e-02 2.395755e-03 8.755265e-02 17 39996701 39996793 93 + 1.063 1.498 1.530
ENSG00000108344 E023 1788.348424 2.142829e-04 2.511099e-05 5.607974e-03 17 39997330 39997380 51 + 3.225 3.274 0.164
ENSG00000108344 E024 2464.575007 1.302048e-04 5.741076e-06 2.041519e-03 17 39997504 39997793 290 + 3.367 3.410 0.143
ENSG00000108344 E025 831.448050 8.612399e-05 7.016482e-02 3.961210e-01 17 39997794 39997959 166 + 2.905 2.929 0.081