ENSG00000106829

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265284 ENSG00000106829 HEK293_DMSO_6hA HEK293_OSMI2_6hA TLE4 protein_coding protein_coding 28.02581 20.75813 28.67173 2.048843 1.629114 0.4657604 1.755150 1.6592749 1.96317814 0.3116904 0.71878719 0.24129964 0.06541667 0.07990000 0.066333333 -0.01356667 0.78484373 0.01944447 FALSE TRUE
ENST00000376544 ENSG00000106829 HEK293_DMSO_6hA HEK293_OSMI2_6hA TLE4 protein_coding protein_coding 28.02581 20.75813 28.67173 2.048843 1.629114 0.4657604 1.837194 1.4753567 1.41333337 0.2161696 0.20363469 -0.06153587 0.06317917 0.07046667 0.048833333 -0.02163333 0.51911338 0.01944447 FALSE TRUE
ENST00000376552 ENSG00000106829 HEK293_DMSO_6hA HEK293_OSMI2_6hA TLE4 protein_coding protein_coding 28.02581 20.75813 28.67173 2.048843 1.629114 0.4657604 9.726946 5.8498613 10.12359647 0.7961851 0.89389506 0.79020786 0.33931667 0.28020000 0.351733333 0.07153333 0.29984567 0.01944447 FALSE TRUE
ENST00000490347 ENSG00000106829 HEK293_DMSO_6hA HEK293_OSMI2_6hA TLE4 protein_coding protein_coding 28.02581 20.75813 28.67173 2.048843 1.629114 0.4657604 2.958984 0.5200640 3.09220156 0.5200640 0.22599108 2.54905409 0.10088333 0.02840000 0.107666667 0.07926667 0.21928157 0.01944447 FALSE TRUE
ENST00000495170 ENSG00000106829 HEK293_DMSO_6hA HEK293_OSMI2_6hA TLE4 protein_coding retained_intron 28.02581 20.75813 28.67173 2.048843 1.629114 0.4657604 0.380910 1.1384708 0.08377983 0.3060389 0.08377983 -3.61429264 0.01440000 0.05326667 0.002733333 -0.05053333 0.01944447 0.01944447   FALSE
MSTRG.32903.11 ENSG00000106829 HEK293_DMSO_6hA HEK293_OSMI2_6hA TLE4 protein_coding   28.02581 20.75813 28.67173 2.048843 1.629114 0.4657604 2.150160 0.7830536 2.06497929 0.7830536 1.25351370 1.38760658 0.07158750 0.04273333 0.071800000 0.02906667 0.73214420 0.01944447 FALSE TRUE
MSTRG.32903.12 ENSG00000106829 HEK293_DMSO_6hA HEK293_OSMI2_6hA TLE4 protein_coding   28.02581 20.75813 28.67173 2.048843 1.629114 0.4657604 2.702001 3.3166261 3.32168233 0.4357631 0.85001438 0.00219112 0.10183333 0.16143333 0.114666667 -0.04676667 0.64468184 0.01944447 FALSE TRUE
MSTRG.32903.25 ENSG00000106829 HEK293_DMSO_6hA HEK293_OSMI2_6hA TLE4 protein_coding   28.02581 20.75813 28.67173 2.048843 1.629114 0.4657604 1.961720 2.6383083 2.23756891 1.4189735 1.14898561 -0.23670573 0.07553333 0.11850000 0.080233333 -0.03826667 0.97818712 0.01944447 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000106829 E001 0.7015170 0.1121879491 0.8203891715   9 79571773 79571940 168 + 0.190 0.241 0.436
ENSG00000106829 E002 13.2577872 0.0021056530 0.4761117595 0.81728818 9 79571941 79571964 24 + 1.120 1.200 0.286
ENSG00000106829 E003 200.9434933 0.0002528275 0.7349775661 0.92752096 9 79571965 79572574 610 + 2.300 2.308 0.028
ENSG00000106829 E004 4.3183203 0.0050695336 0.4379483469 0.79645580 9 79572575 79572591 17 + 0.768 0.673 -0.391
ENSG00000106829 E005 5.5433578 0.0040049743 0.1633401798 0.55820780 9 79572592 79572610 19 + 0.875 0.706 -0.671
ENSG00000106829 E006 5.2808200 0.0045920861 0.1373705010 0.52123961 9 79572611 79572614 4 + 0.859 0.673 -0.748
ENSG00000106829 E007 5.3513925 0.0044157200 0.0487946360 0.34095342 9 79572615 79572624 10 + 0.890 0.638 -1.019
ENSG00000106829 E008 6.3356471 0.0045333572 0.0151053066 0.20907800 9 79572625 79572633 9 + 0.973 0.673 -1.176
ENSG00000106829 E009 7.1580483 0.0033740331 0.0078840264 0.15536058 9 79572634 79572637 4 + 1.020 0.706 -1.214
ENSG00000106829 E010 25.5132080 0.0058428792 0.1023662292 0.46172611 9 79572638 79572711 74 + 1.471 1.360 -0.384
ENSG00000106829 E011 28.2875837 0.0265561102 0.5492247140 0.85364350 9 79572712 79572744 33 + 1.486 1.438 -0.163
ENSG00000106829 E012 57.0343691 0.0034839284 0.0532503745 0.35353760 9 79572745 79572835 91 + 1.799 1.709 -0.305
ENSG00000106829 E013 0.1125166 0.0328693641 0.6211402804   9 79573218 79573251 34 + 0.104 0.000 -12.716
ENSG00000106829 E014 0.1125166 0.0328693641 0.6211402804   9 79573252 79573261 10 + 0.104 0.000 -12.716
ENSG00000106829 E015 0.1125166 0.0328693641 0.6211402804   9 79573262 79573263 2 + 0.104 0.000 -12.716
ENSG00000106829 E016 0.2250332 0.1606644899 0.3308905521   9 79573264 79573296 33 + 0.184 0.000 -12.923
ENSG00000106829 E017 0.2250332 0.1606644899 0.3308905521   9 79573297 79573317 21 + 0.184 0.000 -12.923
ENSG00000106829 E018 10.0733710 0.0025874609 0.3257771275 0.72144387 9 79573318 79573370 53 + 1.082 0.996 -0.316
ENSG00000106829 E019 0.8877295 0.0838156387 0.2955731125   9 79573503 79573688 186 + 0.324 0.137 -1.575
ENSG00000106829 E020 111.4325059 0.0003449044 0.3631488074 0.74916349 9 79573689 79573786 98 + 2.054 2.040 -0.047
ENSG00000106829 E021 0.1125166 0.0328693641 0.6211402804   9 79573933 79574196 264 + 0.104 0.000 -12.716
ENSG00000106829 E022 112.6844067 0.0003716857 0.3788365889 0.75925392 9 79574873 79574936 64 + 2.060 2.048 -0.043
ENSG00000106829 E023 0.3435364 0.3687095617 0.2154666494   9 79574937 79575029 93 + 0.000 0.242 12.383
ENSG00000106829 E024 0.1544607 0.0330876104 0.3783832388   9 79575779 79575779 1 + 0.000 0.137 12.542
ENSG00000106829 E025 0.1544607 0.0330876104 0.3783832388   9 79575780 79576027 248 + 0.000 0.137 12.542
ENSG00000106829 E026 104.0966710 0.0004527549 0.4668392276 0.81222074 9 79576133 79576177 45 + 2.023 2.015 -0.029
ENSG00000106829 E027 1.3448865 0.0542863855 0.7214403591   9 79576178 79576283 106 + 0.320 0.396 0.449
ENSG00000106829 E028 0.3340335 0.0249325842 0.1364207759   9 79576475 79576802 328 + 0.000 0.241 13.638
ENSG00000106829 E029 0.1544607 0.0330876104 0.3783832388   9 79580060 79580185 126 + 0.000 0.137 12.542
ENSG00000106829 E030 0.1544607 0.0330876104 0.3783832388   9 79580227 79580372 146 + 0.000 0.137 12.542
ENSG00000106829 E031 0.5982085 0.0399656051 0.7918280309   9 79601415 79601509 95 + 0.188 0.241 0.454
ENSG00000106829 E032 112.2771655 0.0002915837 0.5467290185 0.85265220 9 79612656 79612718 63 + 2.049 2.046 -0.011
ENSG00000106829 E033 100.6294997 0.0065981992 0.0967400420 0.45135275 9 79627374 79627448 75 + 2.034 1.963 -0.239
ENSG00000106829 E034 0.1544607 0.0330876104 0.3783832388   9 79627449 79627752 304 + 0.000 0.137 12.542
ENSG00000106829 E035 0.8370330 0.0172671820 0.0967445229   9 79649481 79649819 339 + 0.104 0.395 2.453
ENSG00000106829 E036 2.6294173 0.0078086378 0.6520699623 0.89737673 9 79649820 79649858 39 + 0.570 0.509 -0.283
ENSG00000106829 E037 33.2313581 0.0009581038 0.8506752248 0.96312802 9 79652590 79652592 3 + 1.522 1.527 0.018
ENSG00000106829 E038 168.4049255 0.0002012412 0.0529801101 0.35262405 9 79652593 79652685 93 + 2.241 2.205 -0.120
ENSG00000106829 E039 187.0768192 0.0001985196 0.0932517410 0.44448247 9 79652686 79652794 109 + 2.281 2.254 -0.089
ENSG00000106829 E040 0.1544607 0.0330876104 0.3783832388   9 79652795 79652798 4 + 0.000 0.137 12.542
ENSG00000106829 E041 0.1544607 0.0330876104 0.3783832388   9 79652799 79652799 1 + 0.000 0.137 12.542
ENSG00000106829 E042 101.8011240 0.0021885924 0.6427875841 0.89348004 9 79654059 79654075 17 + 2.007 2.005 -0.007
ENSG00000106829 E043 0.1717682 0.0337847017 0.3779681790   9 79663450 79663603 154 + 0.000 0.137 12.535
ENSG00000106829 E044 0.3485388 0.0310123464 0.8421213694   9 79671209 79671338 130 + 0.104 0.137 0.453
ENSG00000106829 E045 0.1767706 0.0357981128 0.6192446282   9 79671339 79671557 219 + 0.104 0.000 -12.693
ENSG00000106829 E046 5.5423564 0.0053733607 0.0002167806 0.02140792 9 79704645 79704782 138 + 0.501 1.012 2.096
ENSG00000106829 E047 113.0732149 0.0002898720 0.6452763137 0.89451879 9 79704783 79704802 20 + 2.050 2.052 0.005
ENSG00000106829 E048 191.2433908 0.0002167135 0.2646390186 0.66961208 9 79704803 79704902 100 + 2.283 2.271 -0.040
ENSG00000106829 E049 154.2627965 0.0002001251 0.0150595274 0.20888083 9 79705889 79705942 54 + 2.208 2.156 -0.176
ENSG00000106829 E050 111.1814176 0.0002943354 0.0066088891 0.14317832 9 79706747 79706765 19 + 2.076 2.000 -0.253
ENSG00000106829 E051 230.0168045 0.0001541521 0.0444907555 0.32824326 9 79706766 79706899 134 + 2.373 2.343 -0.100
ENSG00000106829 E052 14.9813752 0.0605659410 0.0371753085 0.30451882 9 79707123 79707218 96 + 1.038 1.330 1.039
ENSG00000106829 E053 231.9721735 0.0003376345 0.0274393176 0.26887117 9 79708118 79708250 133 + 2.382 2.345 -0.122
ENSG00000106829 E054 251.3087971 0.0001725617 0.0986669700 0.45477418 9 79708593 79708786 194 + 2.409 2.389 -0.067
ENSG00000106829 E055 165.1336839 0.0005937726 0.6677296190 0.90318627 9 79709623 79709699 77 + 2.206 2.235 0.095
ENSG00000106829 E056 11.8406624 0.4383758873 0.3630762299 0.74911453 9 79717997 79718071 75 + 1.031 1.181 0.539
ENSG00000106829 E057 333.1294828 0.0002452685 0.2409240077 0.64601072 9 79718722 79718971 250 + 2.502 2.542 0.132
ENSG00000106829 E058 345.4593961 0.0003668023 0.6343175669 0.88980800 9 79720046 79720293 248 + 2.526 2.551 0.085
ENSG00000106829 E059 263.9145772 0.0001815106 0.1532745614 0.54386721 9 79721741 79721888 148 + 2.427 2.412 -0.049
ENSG00000106829 E060 302.3127191 0.0006934482 0.7386904297 0.92857745 9 79722451 79722601 151 + 2.466 2.490 0.079
ENSG00000106829 E061 251.2256690 0.0011703059 0.0330422358 0.29084223 9 79722959 79723035 77 + 2.363 2.436 0.244
ENSG00000106829 E062 956.7411188 0.0034341574 0.0005186724 0.03687203 9 79725037 79726882 1846 + 2.929 3.033 0.347