ENSG00000106683

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000336180 ENSG00000106683 HEK293_DMSO_6hA HEK293_OSMI2_6hA LIMK1 protein_coding protein_coding 20.02406 16.27443 28.87309 1.780113 6.008553 0.8267323 15.097811 10.98326 25.13980 1.000077 5.6823380 1.1939278 0.7442333 0.6780000 0.8614000 0.1834000 0.0001384263 0.0001384263 FALSE TRUE
ENST00000435201 ENSG00000106683 HEK293_DMSO_6hA HEK293_OSMI2_6hA LIMK1 protein_coding nonsense_mediated_decay 20.02406 16.27443 28.87309 1.780113 6.008553 0.8267323 4.468891 4.51313 3.25305 1.009612 0.6042462 -0.4711005 0.2262417 0.2694333 0.1169667 -0.1524667 0.0140893920 0.0001384263 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000106683 E001 0.0000000       7 74082933 74083179 247 +      
ENSG00000106683 E002 11.9122397 0.0021374859 0.041405411 0.31870427 7 74083804 74083990 187 + 1.013 1.209 0.707
ENSG00000106683 E003 39.6459071 0.0015784223 0.289696194 0.69123443 7 74083991 74084045 55 + 1.571 1.636 0.223
ENSG00000106683 E004 98.5377310 0.0039175979 0.488479443 0.82370571 7 74085748 74085844 97 + 1.975 2.017 0.141
ENSG00000106683 E005 0.1767706 0.0643816154 0.760271644   7 74093079 74093299 221 + 0.096 0.000 -10.573
ENSG00000106683 E006 0.1717682 0.0330636721 0.301870240   7 74093956 74094232 277 + 0.000 0.149 11.052
ENSG00000106683 E007 0.1717682 0.0330636721 0.301870240   7 74094233 74094275 43 + 0.000 0.149 11.052
ENSG00000106683 E008 0.3262289 0.0267872104 0.097628496   7 74094276 74094332 57 + 0.000 0.260 12.151
ENSG00000106683 E009 163.1050006 0.0026979589 0.683267020 0.90951019 7 74096622 74096760 139 + 2.199 2.224 0.084
ENSG00000106683 E010 98.2696255 0.0007462708 0.217792916 0.62243862 7 74097080 74097102 23 + 2.010 1.966 -0.146
ENSG00000106683 E011 146.7900943 0.0012758770 0.068665012 0.39287640 7 74097103 74097189 87 + 2.185 2.130 -0.183
ENSG00000106683 E012 237.7477298 0.0001767786 0.205754983 0.60960139 7 74099032 74099238 207 + 2.386 2.358 -0.093
ENSG00000106683 E013 179.0883663 0.0019367778 0.102579502 0.46208739 7 74105875 74105980 106 + 2.270 2.219 -0.170
ENSG00000106683 E014 209.8237463 0.0022216020 0.325095057 0.72101259 7 74106077 74106243 167 + 2.332 2.302 -0.100
ENSG00000106683 E015 130.0288412 0.0003300328 0.000371131 0.02998525 7 74107010 74107070 61 + 2.159 2.045 -0.381
ENSG00000106683 E016 185.8153012 0.0002826923 0.007060094 0.14813931 7 74107071 74107193 123 + 2.296 2.225 -0.237
ENSG00000106683 E017 195.7312879 0.0001907891 0.155520688 0.54737815 7 74107871 74107957 87 + 2.304 2.269 -0.117
ENSG00000106683 E018 242.6905993 0.0011237919 0.378906954 0.75929392 7 74108905 74109036 132 + 2.387 2.369 -0.060
ENSG00000106683 E019 27.1894051 0.1312733276 0.072099989 0.40014794 7 74109037 74111440 2404 + 1.287 1.596 1.065
ENSG00000106683 E020 203.3387296 0.0020518206 0.690678900 0.91202395 7 74111648 74111707 60 + 2.304 2.301 -0.009
ENSG00000106683 E021 218.1158663 0.0019858169 0.631605094 0.88869788 7 74111933 74111998 66 + 2.324 2.347 0.077
ENSG00000106683 E022 3.6901177 0.5184260345 0.614693971 0.88214985 7 74115368 74115801 434 + 0.524 0.813 1.233
ENSG00000106683 E023 299.6684627 0.0008036410 0.582545913 0.86788104 7 74115802 74115958 157 + 2.462 2.482 0.067
ENSG00000106683 E024 166.7029692 0.0007607262 0.206083014 0.60994874 7 74120583 74120638 56 + 2.197 2.241 0.145
ENSG00000106683 E025 218.5721129 0.0002135092 0.008932216 0.16451348 7 74120892 74121049 158 + 2.308 2.373 0.216
ENSG00000106683 E026 881.0280832 0.0008270126 0.018423031 0.22825137 7 74121139 74122525 1387 + 2.921 2.965 0.149