ENSG00000105875

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000354475 ENSG00000105875 HEK293_DMSO_6hA HEK293_OSMI2_6hA WDR91 protein_coding protein_coding 15.84266 19.5232 17.46689 0.7671916 0.7925132 -0.1604797 1.5710052 1.218412 1.6301147 0.2766376 0.53811108 0.41700251 0.09935000 0.06156667 0.09583333 0.034266667 0.7597046 0.0180746 FALSE TRUE
ENST00000474411 ENSG00000105875 HEK293_DMSO_6hA HEK293_OSMI2_6hA WDR91 protein_coding retained_intron 15.84266 19.5232 17.46689 0.7671916 0.7925132 -0.1604797 1.0685173 1.952528 0.8162966 0.2872516 0.39949613 -1.24798175 0.06760833 0.10056667 0.04513333 -0.055433333 0.3876759 0.0180746 FALSE TRUE
ENST00000682759 ENSG00000105875 HEK293_DMSO_6hA HEK293_OSMI2_6hA WDR91 protein_coding retained_intron 15.84266 19.5232 17.46689 0.7671916 0.7925132 -0.1604797 0.7899727 1.801588 0.5150876 0.1328288 0.09553947 -1.78662504 0.04822083 0.09310000 0.02960000 -0.063500000 0.0180746 0.0180746 TRUE TRUE
MSTRG.30741.12 ENSG00000105875 HEK293_DMSO_6hA HEK293_OSMI2_6hA WDR91 protein_coding   15.84266 19.5232 17.46689 0.7671916 0.7925132 -0.1604797 1.8956869 2.986084 2.7318712 0.1865230 0.34018580 -0.12791749 0.11740833 0.15413333 0.15866667 0.004533333 0.9943195 0.0180746 TRUE TRUE
MSTRG.30741.13 ENSG00000105875 HEK293_DMSO_6hA HEK293_OSMI2_6hA WDR91 protein_coding   15.84266 19.5232 17.46689 0.7671916 0.7925132 -0.1604797 3.6187003 3.258129 4.0247812 0.8142702 0.89148541 0.30402546 0.23218333 0.16456667 0.23533333 0.070766667 0.7413212 0.0180746 FALSE TRUE
MSTRG.30741.20 ENSG00000105875 HEK293_DMSO_6hA HEK293_OSMI2_6hA WDR91 protein_coding   15.84266 19.5232 17.46689 0.7671916 0.7925132 -0.1604797 3.7016222 3.683426 3.7762439 0.2830150 0.28236400 0.03580777 0.23844583 0.18996667 0.21590000 0.025933333 0.7503656 0.0180746 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000105875 E001 3.029944 0.0574442214 0.9998598941 0.99998028 7 135183839 135183851 13 - 0.579 0.594 0.070
ENSG00000105875 E002 7.666771 0.0067948787 0.5001852069 0.82974840 7 135183852 135183889 38 - 0.952 0.887 -0.244
ENSG00000105875 E003 14.306849 0.0268713276 0.2732505619 0.67707889 7 135183890 135184001 112 - 1.231 1.124 -0.378
ENSG00000105875 E004 117.926443 0.0038261021 0.5858525427 0.86940799 7 135184002 135185271 1270 - 2.068 2.061 -0.023
ENSG00000105875 E005 197.898322 0.0032539412 0.6052748376 0.87774889 7 135185272 135185774 503 - 2.271 2.304 0.108
ENSG00000105875 E006 50.727731 0.0112819720 0.9159424793 0.97985936 7 135185775 135185781 7 - 1.692 1.710 0.059
ENSG00000105875 E007 136.715286 0.0002266582 0.8809671060 0.97144229 7 135185782 135185923 142 - 2.114 2.134 0.068
ENSG00000105875 E008 330.223742 0.0010902370 0.2682499232 0.67275632 7 135185924 135186315 392 - 2.486 2.527 0.140
ENSG00000105875 E009 32.325018 0.1698879368 0.1194938887 0.49273908 7 135186316 135186971 656 - 1.372 1.602 0.791
ENSG00000105875 E010 201.396449 0.0036756625 0.2897466213 0.69123443 7 135186972 135187169 198 - 2.311 2.286 -0.082
ENSG00000105875 E011 133.620087 0.0456022485 0.0132377927 0.19823074 7 135187170 135188412 1243 - 1.986 2.204 0.729
ENSG00000105875 E012 14.504252 0.0290314673 0.0006208561 0.04134996 7 135188413 135188432 20 - 0.884 1.315 1.563
ENSG00000105875 E013 92.504413 0.0026654717 0.4145534277 0.78311144 7 135188433 135188449 17 - 1.970 1.951 -0.064
ENSG00000105875 E014 136.203002 0.0033665369 0.4334854789 0.79369111 7 135188450 135188545 96 - 2.137 2.122 -0.053
ENSG00000105875 E015 48.074530 0.0884939342 0.2502838308 0.65610749 7 135188546 135189343 798 - 1.635 1.717 0.279
ENSG00000105875 E016 150.971539 0.0004855337 0.4327229772 0.79332306 7 135189344 135189452 109 - 2.176 2.168 -0.026
ENSG00000105875 E017 5.469572 0.0752913209 0.5432384290 0.85147852 7 135189453 135190522 1070 - 0.743 0.837 0.372
ENSG00000105875 E018 0.615516 0.0193874923 0.8440248424   7 135193215 135193230 16 - 0.227 0.200 -0.239
ENSG00000105875 E019 159.368262 0.0011607351 0.7814587342 0.94255457 7 135193231 135193346 116 - 2.194 2.200 0.022
ENSG00000105875 E020 110.998503 0.0035264846 0.9390388813 0.98565489 7 135193347 135193399 53 - 2.034 2.048 0.045
ENSG00000105875 E021 15.362495 0.0215515767 0.0606103674 0.37307988 7 135193400 135193477 78 - 1.070 1.287 0.773
ENSG00000105875 E022 6.426244 0.0952503876 0.1577889807 0.55096266 7 135193478 135193558 81 - 0.691 0.951 1.023
ENSG00000105875 E023 143.150281 0.0002437147 0.3779847547 0.75864871 7 135193578 135193672 95 - 2.122 2.164 0.141
ENSG00000105875 E024 30.748746 0.1184411619 0.0736397207 0.40344859 7 135193673 135194355 683 - 1.346 1.582 0.812
ENSG00000105875 E025 119.591659 0.0003463895 0.9537266062 0.98926689 7 135194934 135195002 69 - 2.062 2.076 0.047
ENSG00000105875 E026 113.475959 0.0002912174 0.1113906754 0.47808997 7 135195003 135195084 82 - 2.066 2.029 -0.124
ENSG00000105875 E027 93.693944 0.0012716175 0.5257159834 0.84295987 7 135196144 135196184 41 - 1.968 1.956 -0.039
ENSG00000105875 E028 77.222447 0.0046413925 0.6865217344 0.91053241 7 135196185 135196219 35 - 1.887 1.873 -0.044
ENSG00000105875 E029 119.682442 0.0003026001 0.1338802408 0.51602220 7 135196220 135196337 118 - 2.088 2.054 -0.111
ENSG00000105875 E030 20.096181 0.0936781250 0.1794843123 0.57864136 7 135197044 135197423 380 - 1.225 1.372 0.514
ENSG00000105875 E031 18.187973 0.0993122620 0.6057035292 0.87790960 7 135197424 135197992 569 - 1.257 1.291 0.120
ENSG00000105875 E032 133.045867 0.0005356382 0.1145868496 0.48353741 7 135197993 135198151 159 - 2.137 2.103 -0.114
ENSG00000105875 E033 1.628757 0.0107215996 0.3404665414   7 135198152 135201343 3192 - 0.308 0.483 0.982
ENSG00000105875 E034 153.423531 0.0007718405 0.0286186368 0.27414103 7 135204268 135204433 166 - 2.208 2.157 -0.171
ENSG00000105875 E035 8.600948 0.1244954262 0.2603162509 0.66577271 7 135204434 135204465 32 - 0.881 1.026 0.543
ENSG00000105875 E036 44.426086 0.1125745674 0.1516959119 0.54170713 7 135204466 135205927 1462 - 1.565 1.705 0.476
ENSG00000105875 E037 141.457303 0.0005708999 0.0039945812 0.11317115 7 135205928 135206058 131 - 2.184 2.111 -0.243
ENSG00000105875 E038 127.098442 0.0027035772 0.3153714248 0.71249762 7 135207120 135207202 83 - 2.110 2.083 -0.089
ENSG00000105875 E039 178.442859 0.0007928128 0.2231202311 0.62790670 7 135208791 135208998 208 - 2.252 2.232 -0.065
ENSG00000105875 E040 155.717603 0.0043012947 0.3438034060 0.73487029 7 135209576 135209755 180 - 2.201 2.178 -0.074
ENSG00000105875 E041 9.354741 0.0552469690 0.6564474992 0.89932917 7 135210044 135210832 789 - 0.967 1.017 0.184
ENSG00000105875 E042 4.161033 0.0072852740 0.9089587192 0.97816493 7 135210833 135211066 234 - 0.710 0.706 -0.017
ENSG00000105875 E043 3.135969 0.0064569794 0.2431620292 0.64824300 7 135211067 135211379 313 - 0.487 0.681 0.876
ENSG00000105875 E044 90.234810 0.0061972663 0.8047572438 0.94966516 7 135211380 135211555 176 - 1.952 1.956 0.014