ENSG00000105516

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000222122 ENSG00000105516 HEK293_DMSO_6hA HEK293_OSMI2_6hA DBP protein_coding protein_coding 11.11333 9.048946 17.12938 1.441152 2.885826 0.9198997 2.0913228 1.7458171 3.0128528 0.4142729 0.7986536 0.7837681 0.1831500 0.18763333 0.17013333 -0.017500000 0.8300379830 0.0003852837 FALSE  
ENST00000593500 ENSG00000105516 HEK293_DMSO_6hA HEK293_OSMI2_6hA DBP protein_coding protein_coding 11.11333 9.048946 17.12938 1.441152 2.885826 0.9198997 1.8165768 1.1557293 2.6605579 0.1753866 0.8850909 1.1959083 0.1623042 0.12956667 0.14556667 0.016000000 0.8984571075 0.0003852837 FALSE  
ENST00000599385 ENSG00000105516 HEK293_DMSO_6hA HEK293_OSMI2_6hA DBP protein_coding protein_coding 11.11333 9.048946 17.12938 1.441152 2.885826 0.9198997 1.1469327 0.8321401 1.4609659 0.5486694 0.2559224 0.8046317 0.1040167 0.09063333 0.09770000 0.007066667 0.8568602378 0.0003852837 FALSE  
ENST00000601104 ENSG00000105516 HEK293_DMSO_6hA HEK293_OSMI2_6hA DBP protein_coding protein_coding 11.11333 9.048946 17.12938 1.441152 2.885826 0.9198997 0.3187833 0.0000000 0.7974578 0.0000000 0.1972895 6.3353149 0.0324375 0.00000000 0.05080000 0.050800000 0.0003852837 0.0003852837 FALSE  
MSTRG.17445.2 ENSG00000105516 HEK293_DMSO_6hA HEK293_OSMI2_6hA DBP protein_coding   11.11333 9.048946 17.12938 1.441152 2.885826 0.9198997 4.8675445 4.4676955 8.0229742 0.9905853 1.4142922 0.8431778 0.4346958 0.48803333 0.46683333 -0.021200000 0.9042713418 0.0003852837 FALSE  
MSTRG.17445.5 ENSG00000105516 HEK293_DMSO_6hA HEK293_OSMI2_6hA DBP protein_coding   11.11333 9.048946 17.12938 1.441152 2.885826 0.9198997 0.7419269 0.6435293 1.0225384 0.1779096 0.1846533 0.6598715 0.0697625 0.08186667 0.05943333 -0.022433333 0.9137357778 0.0003852837 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000105516 E001 14.384606 0.0115163795 0.113342920 0.48152652 19 48630030 48630684 655 - 1.099 1.262 0.577
ENSG00000105516 E002 7.537700 0.0069985263 0.076646894 0.41054229 19 48630685 48630692 8 - 0.816 1.025 0.793
ENSG00000105516 E003 41.282519 0.0009252682 0.537354855 0.84848641 19 48630693 48630730 38 - 1.628 1.595 -0.111
ENSG00000105516 E004 172.384188 0.0002192893 0.319784661 0.71640057 19 48630731 48631052 322 - 2.242 2.218 -0.078
ENSG00000105516 E005 10.012485 0.0026100407 0.001694318 0.07302048 19 48631053 48633085 2033 - 0.863 1.187 1.196
ENSG00000105516 E006 2.143964 0.0087703161 0.048190376 0.33943633 19 48633086 48633443 358 - 0.604 0.255 -1.916
ENSG00000105516 E007 158.548851 0.0002449118 0.447513269 0.80221740 19 48633444 48633655 212 - 2.187 2.207 0.067
ENSG00000105516 E008 9.015448 0.0179050589 0.051064825 0.34704102 19 48633656 48634348 693 - 0.863 1.116 0.936
ENSG00000105516 E009 18.240595 0.0053292161 0.646341470 0.89504445 19 48634349 48634507 159 - 1.301 1.260 -0.141
ENSG00000105516 E010 7.581102 0.0035138854 0.668716830 0.90372785 19 48634508 48634698 191 - 0.905 0.954 0.185
ENSG00000105516 E011 24.275816 0.0768208362 0.459811075 0.80843786 19 48634699 48635579 881 - 1.356 1.448 0.315
ENSG00000105516 E012 53.537114 0.0005605974 0.068508341 0.39243087 19 48635580 48635785 206 - 1.762 1.676 -0.292
ENSG00000105516 E013 46.208936 0.0086908899 0.043189052 0.32407567 19 48635786 48635990 205 - 1.716 1.588 -0.435
ENSG00000105516 E014 162.421229 0.0002742502 0.677571319 0.90727377 19 48636856 48637379 524 - 2.199 2.211 0.039