ENSG00000104983

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000536603 ENSG00000104983 HEK293_DMSO_6hA HEK293_OSMI2_6hA CCDC61 protein_coding protein_coding 4.462976 5.142216 6.677959 0.8151016 0.09302573 0.376373 1.5246977 1.6371867 3.11185698 0.09402367 0.40192406 0.9224004 0.30342500 0.33113333 0.466466667 0.13533333 0.46165518 0.04086144 FALSE TRUE
ENST00000594672 ENSG00000104983 HEK293_DMSO_6hA HEK293_OSMI2_6hA CCDC61 protein_coding protein_coding 4.462976 5.142216 6.677959 0.8151016 0.09302573 0.376373 0.3905320 0.3534976 0.61058397 0.21368103 0.18639674 0.7716805 0.09814167 0.06310000 0.091533333 0.02843333 0.76347404 0.04086144   FALSE
ENST00000595358 ENSG00000104983 HEK293_DMSO_6hA HEK293_OSMI2_6hA CCDC61 protein_coding protein_coding 4.462976 5.142216 6.677959 0.8151016 0.09302573 0.376373 1.5979001 1.0101952 1.88604364 0.28858697 0.45966038 0.8941470 0.33914167 0.21746667 0.281133333 0.06366667 0.76281118 0.04086144 FALSE TRUE
ENST00000601763 ENSG00000104983 HEK293_DMSO_6hA HEK293_OSMI2_6hA CCDC61 protein_coding processed_transcript 4.462976 5.142216 6.677959 0.8151016 0.09302573 0.376373 0.3929024 1.2210958 0.69972727 0.49990898 0.37994508 -0.7946064 0.09237083 0.21413333 0.105633333 -0.10850000 0.74126348 0.04086144   FALSE
MSTRG.17347.1 ENSG00000104983 HEK293_DMSO_6hA HEK293_OSMI2_6hA CCDC61 protein_coding   4.462976 5.142216 6.677959 0.8151016 0.09302573 0.376373 0.1608199 0.3224669 0.03370515 0.07022688 0.03370515 -2.9273359 0.05462917 0.06383333 0.004933333 -0.05890000 0.04086144 0.04086144 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000104983 E001 0.0000000       19 45995452 45995460 9 +      
ENSG00000104983 E002 0.2250332 0.0517533676 0.2960662460   19 45995461 45995466 6 + 0.191 0.000 -10.875
ENSG00000104983 E003 0.5093179 0.1630454527 0.5566771429   19 45995467 45995470 4 + 0.257 0.134 -1.158
ENSG00000104983 E004 1.6467172 0.0109345620 0.2815290327 0.68456235 19 45995471 45995478 8 + 0.509 0.318 -1.044
ENSG00000104983 E005 17.3644006 0.0073459081 0.2773643476 0.68084449 19 45995479 45995504 26 + 1.306 1.208 -0.346
ENSG00000104983 E006 3.1622975 0.0109866575 0.7739289125 0.94053766 19 45996245 45996401 157 + 0.638 0.589 -0.215
ENSG00000104983 E007 2.7825766 0.0259567642 0.0019128944 0.07780307 19 46003006 46003007 2 + 0.264 0.781 2.589
ENSG00000104983 E008 38.5328980 0.0182001818 0.3458582319 0.73600044 19 46003008 46003166 159 + 1.629 1.555 -0.252
ENSG00000104983 E009 3.0306554 0.0773507475 0.4141356989 0.78290148 19 46003167 46003418 252 + 0.517 0.663 0.654
ENSG00000104983 E010 28.6913568 0.0012650849 0.2118272009 0.61637662 19 46003419 46003501 83 + 1.508 1.425 -0.287
ENSG00000104983 E011 0.1717682 0.0324849487 0.3869701919   19 46003502 46003543 42 + 0.000 0.134 10.462
ENSG00000104983 E012 41.1488282 0.0114282021 0.4773712935 0.81795802 19 46006559 46006716 158 + 1.642 1.598 -0.151
ENSG00000104983 E013 34.4452997 0.0009880451 0.9642867512 0.99181916 19 46008140 46008301 162 + 1.554 1.551 -0.008
ENSG00000104983 E014 16.8276428 0.0017741711 0.8674802410 0.96742884 19 46015049 46015259 211 + 1.255 1.263 0.028
ENSG00000104983 E015 0.8643453 0.4458460613 0.9751809113   19 46015260 46015333 74 + 0.276 0.235 -0.306
ENSG00000104983 E016 7.6280806 0.0036877975 0.1871621497 0.58820818 19 46015345 46015427 83 + 0.853 1.001 0.555
ENSG00000104983 E017 1.6275950 0.0178451594 0.0980495234   19 46015428 46015428 1 + 0.264 0.547 1.598
ENSG00000104983 E018 9.6889146 0.0099910105 0.4966573114 0.82761568 19 46016054 46016223 170 + 1.005 1.073 0.247
ENSG00000104983 E019 11.3349132 0.0036990541 0.1503154632 0.53979994 19 46016318 46016393 76 + 1.020 1.157 0.496
ENSG00000104983 E020 25.2659174 0.0016480833 0.5322821803 0.84621776 19 46016694 46016833 140 + 1.406 1.442 0.125
ENSG00000104983 E021 21.9835740 0.0051779191 0.3475822854 0.73742711 19 46016991 46017069 79 + 1.396 1.319 -0.268
ENSG00000104983 E022 27.5344491 0.0215363001 0.2959236997 0.69647228 19 46017247 46017304 58 + 1.493 1.404 -0.308
ENSG00000104983 E023 33.6743778 0.0207875351 0.8769668391 0.97042603 19 46018078 46018150 73 + 1.547 1.538 -0.031
ENSG00000104983 E024 39.7371969 0.0012839291 0.5265946024 0.84326118 19 46018290 46018378 89 + 1.604 1.632 0.095
ENSG00000104983 E025 26.6575666 0.0115403669 0.4829307500 0.82092757 19 46018379 46018432 54 + 1.431 1.475 0.152
ENSG00000104983 E026 24.4308475 0.0013898322 0.8398898859 0.96025413 19 46018433 46018522 90 + 1.420 1.401 -0.068
ENSG00000104983 E027 14.8817030 0.0018261794 0.5170125874 0.83864583 19 46018523 46018616 94 + 1.227 1.167 -0.214
ENSG00000104983 E028 6.6615859 0.0527287222 0.0492901493 0.34235800 19 46021082 46021318 237 + 0.718 1.015 1.145
ENSG00000104983 E029 3.2620435 0.0070607636 0.0009511157 0.05243128 19 46023373 46023513 141 + 0.325 0.830 2.371