ENSG00000103707

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000220058 ENSG00000103707 HEK293_DMSO_6hA HEK293_OSMI2_6hA MTFMT protein_coding protein_coding 12.25758 6.402345 10.33421 0.4860301 2.71049 0.6898991 2.071602 1.1068295 1.5239546 0.0995660 0.41362694 0.45784682 0.1695750 0.17286667 0.14630000 -0.02656667 0.7549930 0.0317971 FALSE TRUE
ENST00000558460 ENSG00000103707 HEK293_DMSO_6hA HEK293_OSMI2_6hA MTFMT protein_coding nonsense_mediated_decay 12.25758 6.402345 10.33421 0.4860301 2.71049 0.6898991 4.730483 2.0579510 2.8032141 0.3820968 0.57199269 0.44401732 0.3807917 0.32480000 0.28583333 -0.03896667 0.8446408 0.0317971 TRUE TRUE
ENST00000559633 ENSG00000103707 HEK293_DMSO_6hA HEK293_OSMI2_6hA MTFMT protein_coding retained_intron 12.25758 6.402345 10.33421 0.4860301 2.71049 0.6898991 1.232979 0.7534987 3.3538563 0.1173782 1.16274008 2.13941842 0.1051792 0.11776667 0.30490000 0.18713333 0.0317971 0.0317971 FALSE TRUE
ENST00000561025 ENSG00000103707 HEK293_DMSO_6hA HEK293_OSMI2_6hA MTFMT protein_coding processed_transcript 12.25758 6.402345 10.33421 0.4860301 2.71049 0.6898991 0.666882 0.6799316 0.1386171 0.5297698 0.13861709 -2.21485336 0.0559000 0.11100000 0.01036667 -0.10063333 0.6539425 0.0317971   FALSE
MSTRG.11046.3 ENSG00000103707 HEK293_DMSO_6hA HEK293_OSMI2_6hA MTFMT protein_coding   12.25758 6.402345 10.33421 0.4860301 2.71049 0.6898991 1.150840 0.4124920 1.3633440 0.0443329 0.54964117 1.70069710 0.0916750 0.06433333 0.11973333 0.05540000 0.4407486 0.0317971 FALSE TRUE
MSTRG.11046.4 ENSG00000103707 HEK293_DMSO_6hA HEK293_OSMI2_6hA MTFMT protein_coding   12.25758 6.402345 10.33421 0.4860301 2.71049 0.6898991 2.103780 1.0962855 1.1383243 0.6914100 0.05907566 0.05380626 0.1700667 0.15713333 0.13026667 -0.02686667 0.9436821 0.0317971 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000103707 E001 8.5354124 0.0033319075 8.220801e-01 0.955002906 15 65001512 65002577 1066 - 0.958 0.982 0.087
ENSG00000103707 E002 25.6629612 0.0014240095 9.428229e-01 0.986610857 15 65002578 65002718 141 - 1.432 1.433 0.004
ENSG00000103707 E003 33.4849537 0.0015670695 9.556759e-01 0.989812771 15 65002719 65002853 135 - 1.545 1.544 -0.004
ENSG00000103707 E004 23.3551472 0.0013319653 9.782922e-01 0.994845568 15 65002854 65002934 81 - 1.392 1.389 -0.008
ENSG00000103707 E005 19.5495284 0.0015232836 9.872633e-01 0.996858697 15 65002935 65002990 56 - 1.315 1.310 -0.018
ENSG00000103707 E006 11.2368779 0.0026019173 6.699026e-02 0.388986203 15 65002991 65002995 5 - 0.995 1.170 0.635
ENSG00000103707 E007 76.2996477 0.0004572807 4.433401e-05 0.008233734 15 65002996 65003256 261 - 1.815 1.966 0.508
ENSG00000103707 E008 55.6164052 0.0015465973 1.801411e-02 0.225887275 15 65004854 65004936 83 - 1.706 1.814 0.364
ENSG00000103707 E009 44.2442087 0.0007413759 1.612404e-01 0.555981133 15 65006113 65006191 79 - 1.627 1.695 0.228
ENSG00000103707 E010 0.3535412 0.8742444359 5.054866e-01   15 65015833 65016254 422 - 0.198 0.000 -9.972
ENSG00000103707 E011 0.1795728 0.0344517979 3.665497e-01   15 65016255 65016435 181 - 0.000 0.138 9.643
ENSG00000103707 E012 41.0335993 0.0009343688 6.514284e-01 0.897138249 15 65016436 65016527 92 - 1.614 1.635 0.072
ENSG00000103707 E013 35.6917063 0.0064884856 3.350608e-01 0.728287641 15 65020197 65020272 76 - 1.587 1.520 -0.231
ENSG00000103707 E014 44.6911769 0.0064473087 1.888942e-01 0.590285224 15 65021514 65021616 103 - 1.687 1.605 -0.281
ENSG00000103707 E015 41.0515128 0.0010397341 5.728762e-01 0.863496786 15 65023672 65023770 99 - 1.633 1.600 -0.113
ENSG00000103707 E016 26.7783916 0.0010853876 4.675610e-01 0.812712951 15 65023771 65023794 24 - 1.466 1.415 -0.175
ENSG00000103707 E017 1.7132105 0.0109074112 7.988064e-01 0.947945577 15 65026748 65026817 70 - 0.417 0.457 0.209
ENSG00000103707 E018 1.8911461 0.0097752579 2.525163e-01 0.658404290 15 65026818 65026830 13 - 0.370 0.558 0.959
ENSG00000103707 E019 81.5148779 0.0032807217 6.633075e-02 0.387420484 15 65026831 65027040 210 - 1.952 1.870 -0.275
ENSG00000103707 E020 4.3074134 0.0054439809 8.151560e-03 0.157673269 15 65029252 65029404 153 - 0.857 0.457 -1.731
ENSG00000103707 E021 51.0070616 0.0005335710 1.484124e-04 0.017084915 15 65029405 65029639 235 - 1.791 1.604 -0.634