ENSG00000102977

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000620761 ENSG00000102977 HEK293_DMSO_6hA HEK293_OSMI2_6hA ACD protein_coding protein_coding 28.88291 32.25501 41.45878 3.825797 5.24987 0.3620551 14.914845 12.682652 24.7291381 1.8329687 3.6891456 0.96280165 0.5102042 0.3904667 0.5937 0.2032333 0.0005915064 0.0005915064 FALSE TRUE
ENST00000695702 ENSG00000102977 HEK293_DMSO_6hA HEK293_OSMI2_6hA ACD protein_coding retained_intron 28.88291 32.25501 41.45878 3.825797 5.24987 0.3620551 1.179670 2.272346 0.7363068 0.1233062 0.7363068 -1.61267669 0.0534500 0.0719000 0.0227 -0.0492000 0.2409654927 0.0005915064   FALSE
ENST00000695731 ENSG00000102977 HEK293_DMSO_6hA HEK293_OSMI2_6hA ACD protein_coding nonsense_mediated_decay 28.88291 32.25501 41.45878 3.825797 5.24987 0.3620551 4.206788 5.310284 5.1749802 0.8125532 1.7984275 -0.03716486 0.1188375 0.1633000 0.1181 -0.0452000 0.6854087321 0.0005915064 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000102977 E001 0.3312313 0.0394529362 0.8654262723   16 67657512 67657521 10 - 0.107 0.133 0.358
ENSG00000102977 E002 0.3312313 0.0394529362 0.8654262723   16 67657522 67657528 7 - 0.107 0.133 0.358
ENSG00000102977 E003 0.8615430 0.8676054035 0.7217959954   16 67657529 67657529 1 - 0.350 0.131 -1.812
ENSG00000102977 E004 1.2145213 0.3104095156 0.5737267313   16 67657530 67657531 2 - 0.398 0.234 -1.066
ENSG00000102977 E005 1.8629541 0.1300763254 0.6662422302 0.90279118 16 67657532 67657532 1 - 0.480 0.388 -0.486
ENSG00000102977 E006 12.1524781 0.0113109860 0.9434065222 0.98682236 16 67657533 67657543 11 - 1.108 1.110 0.006
ENSG00000102977 E007 12.3292487 0.0141825710 0.8688552182 0.96777685 16 67657544 67657545 2 - 1.118 1.110 -0.031
ENSG00000102977 E008 17.3282046 0.0022134148 0.9160884091 0.97985936 16 67657546 67657560 15 - 1.243 1.262 0.064
ENSG00000102977 E009 38.0007489 0.0011784078 0.6913502863 0.91226200 16 67657561 67657573 13 - 1.594 1.580 -0.047
ENSG00000102977 E010 41.3047637 0.0008741978 0.5563182949 0.85655334 16 67657574 67657577 4 - 1.635 1.612 -0.079
ENSG00000102977 E011 47.9611697 0.0019141704 0.3189565683 0.71576510 16 67657578 67657579 2 - 1.711 1.666 -0.154
ENSG00000102977 E012 49.4609097 0.0041876324 0.3115493775 0.70932960 16 67657580 67657580 1 - 1.728 1.677 -0.175
ENSG00000102977 E013 72.0971151 0.0021862196 0.7654351705 0.93776000 16 67657581 67657592 12 - 1.863 1.859 -0.013
ENSG00000102977 E014 73.7714255 0.0032625527 0.7826004286 0.94300539 16 67657593 67657593 1 - 1.874 1.870 -0.012
ENSG00000102977 E015 75.6150230 0.0031200357 0.7113836087 0.91919831 16 67657594 67657595 2 - 1.887 1.879 -0.027
ENSG00000102977 E016 111.1900574 0.0033063089 0.4019448906 0.77476806 16 67657596 67657624 29 - 2.023 2.072 0.165
ENSG00000102977 E017 187.2075099 0.0019228526 0.7285802044 0.92528642 16 67657625 67657684 60 - 2.261 2.285 0.080
ENSG00000102977 E018 13.2479657 0.0794101063 0.3098842149 0.70807164 16 67657685 67657701 17 - 1.058 1.229 0.613
ENSG00000102977 E019 15.1792459 0.0675086917 0.0996951578 0.45669223 16 67657702 67657746 45 - 1.071 1.320 0.886
ENSG00000102977 E020 12.9635764 0.0063215146 0.0481177988 0.33919273 16 67657747 67657761 15 - 1.033 1.235 0.726
ENSG00000102977 E021 161.8922118 0.0005719711 0.9641084475 0.99176683 16 67657762 67657777 16 - 2.204 2.213 0.031
ENSG00000102977 E022 203.6082630 0.0002756973 0.3493172589 0.73878157 16 67657778 67657814 37 - 2.316 2.302 -0.048
ENSG00000102977 E023 219.8244217 0.0003537467 0.8988733305 0.97586665 16 67657815 67657853 39 - 2.340 2.346 0.020
ENSG00000102977 E024 8.1015039 0.0063927992 0.0019766535 0.07907998 16 67657854 67657871 18 - 0.739 1.110 1.406
ENSG00000102977 E025 17.0108235 0.0650887659 0.1509128409 0.54071690 16 67657872 67657985 114 - 1.141 1.343 0.715
ENSG00000102977 E026 247.1598032 0.0013814783 0.7227564165 0.92311141 16 67657986 67658028 43 - 2.394 2.394 0.001
ENSG00000102977 E027 238.9459212 0.0050450834 0.8870046844 0.97293154 16 67658029 67658061 33 - 2.372 2.389 0.057
ENSG00000102977 E028 350.3820181 0.0035616462 0.5232756921 0.84173692 16 67658062 67658139 78 - 2.529 2.564 0.118
ENSG00000102977 E029 251.6249575 0.0001995742 0.1233278660 0.49941442 16 67658140 67658172 33 - 2.380 2.424 0.148
ENSG00000102977 E030 260.6591392 0.0001720082 0.4189228122 0.78560418 16 67658173 67658205 33 - 2.404 2.431 0.091
ENSG00000102977 E031 215.1622143 0.0001868356 0.1868496902 0.58791750 16 67658206 67658225 20 - 2.310 2.352 0.140
ENSG00000102977 E032 181.3830114 0.0002030639 0.9201771040 0.98083020 16 67658226 67658234 9 - 2.250 2.262 0.041
ENSG00000102977 E033 241.9676050 0.0001395248 0.4597875918 0.80843786 16 67658235 67658282 48 - 2.370 2.396 0.087
ENSG00000102977 E034 167.7790502 0.0001916341 0.0514040442 0.34801899 16 67658283 67658287 5 - 2.194 2.256 0.209
ENSG00000102977 E035 164.0692103 0.0002110930 0.0292183464 0.27648737 16 67658288 67658293 6 - 2.183 2.252 0.232
ENSG00000102977 E036 261.4458194 0.0001511476 0.6602982236 0.90068355 16 67658294 67658362 69 - 2.406 2.426 0.064
ENSG00000102977 E037 19.1571241 0.0392400483 0.0278560752 0.27059300 16 67658363 67658554 192 - 1.145 1.421 0.968
ENSG00000102977 E038 296.6639708 0.0026781152 0.1181830066 0.49040414 16 67658555 67658641 87 - 2.484 2.455 -0.096
ENSG00000102977 E039 14.7299915 0.0020107065 0.0093608539 0.16842321 16 67658642 67658719 78 - 1.065 1.302 0.844
ENSG00000102977 E040 197.9245195 0.0008544069 0.0318255873 0.28662010 16 67658720 67658735 16 - 2.316 2.268 -0.161
ENSG00000102977 E041 175.4541588 0.0003064949 0.0364596156 0.30194845 16 67658736 67658742 7 - 2.263 2.216 -0.157
ENSG00000102977 E042 299.5831423 0.0004789258 0.0417391896 0.31964457 16 67658743 67658816 74 - 2.490 2.455 -0.117
ENSG00000102977 E043 17.6819459 0.0666116715 0.0247907776 0.25773605 16 67658817 67658832 16 - 1.093 1.407 1.108
ENSG00000102977 E044 23.5083380 0.1975791378 0.0366589097 0.30259488 16 67658833 67658927 95 - 1.170 1.547 1.313
ENSG00000102977 E045 414.7257624 0.0001271905 0.0695829803 0.39475072 16 67658928 67659079 152 - 2.625 2.603 -0.073
ENSG00000102977 E046 68.3089254 0.1846812685 0.0414452413 0.31882686 16 67659080 67659228 149 - 1.661 1.980 1.074
ENSG00000102977 E047 233.9753974 0.0002752487 0.8387116939 0.95978041 16 67659229 67659263 35 - 2.365 2.370 0.016
ENSG00000102977 E048 54.1409813 0.2439799902 0.0248426736 0.25785497 16 67659264 67659374 111 - 1.506 1.908 1.364
ENSG00000102977 E049 214.1694222 0.0001770747 0.4014799255 0.77432610 16 67659375 67659419 45 - 2.336 2.325 -0.037
ENSG00000102977 E050 31.3314152 0.1960557795 0.0764024604 0.41015441 16 67659420 67659464 45 - 1.347 1.639 1.002
ENSG00000102977 E051 34.5452504 0.2307663520 0.0899470273 0.43848287 16 67659465 67659536 72 - 1.394 1.677 0.970
ENSG00000102977 E052 230.3204968 0.0001720767 0.0001681122 0.01837439 16 67659537 67659613 77 - 2.399 2.319 -0.265
ENSG00000102977 E053 14.2972888 0.0834422271 0.0820634480 0.42210864 16 67659614 67659701 88 - 1.031 1.304 0.975
ENSG00000102977 E054 118.5937947 0.0033014433 0.0815053543 0.42085787 16 67659702 67659719 18 - 2.109 2.041 -0.229
ENSG00000102977 E055 217.5599069 0.0002569171 0.0297532425 0.27851335 16 67659720 67659788 69 - 2.360 2.316 -0.148
ENSG00000102977 E056 153.2858018 0.0002490084 0.2937527403 0.69446878 16 67659789 67659795 7 - 2.197 2.176 -0.070
ENSG00000102977 E057 3.9480446 0.0069181406 0.0194700784 0.23305625 16 67659877 67659902 26 - 0.509 0.852 1.456
ENSG00000102977 E058 298.4278166 0.0001842201 0.0255342279 0.26049629 16 67659903 67660036 134 - 2.494 2.456 -0.124
ENSG00000102977 E059 136.8781331 0.0003729044 0.0572913565 0.36462741 16 67660037 67660045 9 - 2.161 2.112 -0.165
ENSG00000102977 E060 31.8023625 0.0208184232 0.2249142722 0.62997057 16 67660046 67660121 76 - 1.456 1.580 0.428
ENSG00000102977 E061 232.7613214 0.0004765786 0.0358892011 0.30017987 16 67660122 67660810 689 - 2.388 2.346 -0.142