ENSG00000102931

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000219204 ENSG00000102931 HEK293_DMSO_6hA HEK293_OSMI2_6hA ARL2BP protein_coding protein_coding 59.61944 39.02576 47.95828 5.610824 9.610862 0.2972844 41.177047 27.505274 31.570659 3.6752066 5.485977 0.1988086 0.69770833 0.70990000 0.6738333 -0.03606667 0.79966447 0.01407784 FALSE TRUE
MSTRG.12711.1 ENSG00000102931 HEK293_DMSO_6hA HEK293_OSMI2_6hA ARL2BP protein_coding   59.61944 39.02576 47.95828 5.610824 9.610862 0.2972844 3.925034 2.029037 6.250560 0.6809036 1.433402 1.6184040 0.06567917 0.04936667 0.1290333 0.07966667 0.01407784 0.01407784 FALSE TRUE
MSTRG.12711.2 ENSG00000102931 HEK293_DMSO_6hA HEK293_OSMI2_6hA ARL2BP protein_coding   59.61944 39.02576 47.95828 5.610824 9.610862 0.2972844 10.190207 5.532032 6.177057 0.6433871 1.455574 0.1588385 0.16704167 0.14316667 0.1279333 -0.01523333 0.75778228 0.01407784 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000102931 E001 2.296787 0.0081736180 0.1202818036 0.49408238 16 57245129 57245136 8 + 0.622 0.377 -1.205
ENSG00000102931 E002 74.835097 0.0004350437 0.0002605287 0.02414538 16 57245137 57245258 122 + 1.943 1.811 -0.444
ENSG00000102931 E003 133.022244 0.0003728702 0.0009634802 0.05276184 16 57245259 57245349 91 + 2.171 2.086 -0.284
ENSG00000102931 E004 116.495870 0.0002726531 0.0048219568 0.12458127 16 57245350 57245375 26 + 2.109 2.035 -0.249
ENSG00000102931 E005 125.287681 0.0002326032 0.0160452397 0.21517379 16 57245376 57245405 30 + 2.131 2.073 -0.194
ENSG00000102931 E006 1.436316 0.1343485703 0.3208415555   16 57246055 57246079 25 + 0.273 0.485 1.229
ENSG00000102931 E007 173.433579 0.0002583986 0.0631302114 0.38011030 16 57246080 57246141 62 + 2.261 2.228 -0.109
ENSG00000102931 E008 218.992555 0.0009275760 0.4395580148 0.79748731 16 57248537 57248643 107 + 2.349 2.345 -0.014
ENSG00000102931 E009 115.021824 0.0004023655 0.3499828468 0.73940421 16 57249767 57249779 13 + 2.077 2.063 -0.049
ENSG00000102931 E010 229.581103 0.0001940950 0.8033011175 0.94925640 16 57249780 57249852 73 + 2.361 2.372 0.037
ENSG00000102931 E011 1.970595 0.0093720677 0.0493968087 0.34266297 16 57250392 57250410 19 + 0.272 0.614 1.838
ENSG00000102931 E012 285.271170 0.0002548607 0.3464777912 0.73646086 16 57250411 57250507 97 + 2.442 2.478 0.121
ENSG00000102931 E013 6.678662 0.0075753347 0.2396349502 0.64481542 16 57250508 57250511 4 + 0.813 0.969 0.596
ENSG00000102931 E014 292.216961 0.0001247804 0.5244891391 0.84238559 16 57252166 57252241 76 + 2.453 2.483 0.099
ENSG00000102931 E015 1824.033252 0.0017235554 0.0276641518 0.26970830 16 57252242 57253635 1394 + 3.237 3.286 0.163