ENSG00000102119

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000369835 ENSG00000102119 HEK293_DMSO_6hA HEK293_OSMI2_6hA EMD protein_coding protein_coding 327.1164 241.3102 539.8646 27.00642 129.9451 1.161676 37.622390 19.68301 66.27243 4.571605 21.78940 1.750943 0.11578750 0.08066667 0.1171333 0.03646667 3.390298e-01 1.078791e-25 FALSE TRUE
ENST00000369842 ENSG00000102119 HEK293_DMSO_6hA HEK293_OSMI2_6hA EMD protein_coding protein_coding 327.1164 241.3102 539.8646 27.00642 129.9451 1.161676 166.167176 107.74458 274.62461 17.900988 70.91754 1.349764 0.50316250 0.44123333 0.5025333 0.06130000 4.713923e-01 1.078791e-25 FALSE TRUE
ENST00000492448 ENSG00000102119 HEK293_DMSO_6hA HEK293_OSMI2_6hA EMD protein_coding processed_transcript 327.1164 241.3102 539.8646 27.00642 129.9451 1.161676 78.659171 53.34866 132.34532 6.779552 28.93116 1.310622 0.22107083 0.22066667 0.2488333 0.02816667 4.781211e-01 1.078791e-25 FALSE TRUE
ENST00000683627 ENSG00000102119 HEK293_DMSO_6hA HEK293_OSMI2_6hA EMD protein_coding protein_coding 327.1164 241.3102 539.8646 27.00642 129.9451 1.161676 6.227814 18.94637 0.00000 6.473335 0.00000 -10.888467 0.02475417 0.08216667 0.0000000 -0.08216667 1.078791e-25 1.078791e-25 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000102119 E001 139.88159 1.731310e-02 0.054084722 0.35616730 X 154379273 154379294 22 + 2.168 2.053 -0.383
ENSG00000102119 E002 239.19718 1.428965e-02 0.057061623 0.36395783 X 154379295 154379340 46 + 2.395 2.294 -0.340
ENSG00000102119 E003 332.78254 7.322456e-03 0.001987451 0.07934234 X 154379341 154379360 20 + 2.548 2.414 -0.445
ENSG00000102119 E004 714.54378 6.190574e-03 0.019199208 0.23163572 X 154379361 154379403 43 + 2.863 2.779 -0.280
ENSG00000102119 E005 822.69434 4.261827e-03 0.032140503 0.28787474 X 154379404 154379416 13 + 2.917 2.857 -0.199
ENSG00000102119 E006 857.29763 3.074842e-03 0.039402298 0.31230283 X 154379417 154379427 11 + 2.931 2.883 -0.162
ENSG00000102119 E007 1314.41356 2.228588e-03 0.102435490 0.46181192 X 154379428 154379484 57 + 3.110 3.081 -0.095
ENSG00000102119 E008 1263.62914 1.795438e-03 0.199783599 0.60317641 X 154379485 154379508 24 + 3.091 3.070 -0.068
ENSG00000102119 E009 1168.35912 1.642529e-03 0.290818111 0.69215098 X 154379509 154379524 16 + 3.055 3.040 -0.050
ENSG00000102119 E010 1181.09240 1.263280e-03 0.333977370 0.72762008 X 154379525 154379537 13 + 3.058 3.047 -0.037
ENSG00000102119 E011 1304.85537 9.208656e-04 0.163970801 0.55906007 X 154379538 154379562 25 + 3.105 3.086 -0.064
ENSG00000102119 E012 904.01786 8.969677e-04 0.242891409 0.64792540 X 154379563 154379566 4 + 2.944 2.928 -0.056
ENSG00000102119 E013 32.99074 2.444498e-02 0.051100141 0.34716659 X 154379625 154379689 65 + 1.432 1.630 0.681
ENSG00000102119 E014 2049.76260 7.475780e-04 0.712975626 0.91965686 X 154379690 154379794 105 + 3.292 3.295 0.010
ENSG00000102119 E015 2272.63525 8.004256e-04 0.681639190 0.90877730 X 154379942 154380019 78 + 3.333 3.346 0.043
ENSG00000102119 E016 224.94798 5.147944e-02 0.014527821 0.20590918 X 154380020 154380233 214 + 2.207 2.501 0.982
ENSG00000102119 E017 2018.61686 6.475926e-04 0.994429411 0.99858251 X 154380234 154380276 43 + 3.285 3.291 0.020
ENSG00000102119 E018 2619.20553 2.067391e-04 0.557610509 0.85717975 X 154380277 154380367 91 + 3.402 3.400 -0.007
ENSG00000102119 E019 122.58700 7.447180e-02 0.023419499 0.25202672 X 154380368 154380462 95 + 1.927 2.254 1.094
ENSG00000102119 E020 168.24623 9.438449e-02 0.027039659 0.26703916 X 154380565 154380752 188 + 2.055 2.398 1.148
ENSG00000102119 E021 2214.43405 5.395555e-05 0.361757895 0.74803203 X 154380753 154380802 50 + 3.333 3.325 -0.028
ENSG00000102119 E022 150.80462 3.559336e-02 0.011507919 0.18541614 X 154380803 154380881 79 + 2.048 2.314 0.888
ENSG00000102119 E023 3788.49817 5.554822e-04 0.593812937 0.87294170 X 154380882 154381004 123 + 3.557 3.564 0.023
ENSG00000102119 E024 4385.09648 1.386469e-03 0.270496299 0.67477075 X 154381005 154381230 226 + 3.609 3.646 0.122
ENSG00000102119 E025 814.82900 1.833522e-03 0.908866079 0.97815207 X 154381231 154381331 101 + 2.884 2.906 0.074
ENSG00000102119 E026 963.09035 4.442480e-03 0.004176887 0.11584064 X 154381332 154381387 56 + 2.917 3.040 0.409
ENSG00000102119 E027 1053.35474 5.011065e-03 0.004237515 0.11668760 X 154381388 154381574 187 + 2.954 3.081 0.424