ENSG00000101986

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000218104 ENSG00000101986 HEK293_DMSO_6hA HEK293_OSMI2_6hA ABCD1 protein_coding protein_coding 6.871685 8.442842 11.83428 1.192634 1.531113 0.4866818 4.6610236 4.8248709 8.953698 0.5211097 1.3576850 0.89061661 0.69380417 0.57920000 0.7522 0.17300000 0.02075337 0.02075337 FALSE TRUE
ENST00000370129 ENSG00000101986 HEK293_DMSO_6hA HEK293_OSMI2_6hA ABCD1 protein_coding protein_coding 6.871685 8.442842 11.83428 1.192634 1.531113 0.4866818 1.7031437 2.5382861 2.690946 0.2889368 0.1343539 0.08393752 0.22993750 0.30333333 0.2328 -0.07053333 0.46309633 0.02075337 FALSE TRUE
ENST00000443684 ENSG00000101986 HEK293_DMSO_6hA HEK293_OSMI2_6hA ABCD1 protein_coding processed_transcript 6.871685 8.442842 11.83428 1.192634 1.531113 0.4866818 0.1704561 0.5480881 0.000000 0.3800186 0.0000000 -5.80242102 0.02362500 0.06176667 0.0000 -0.06176667 0.25180384 0.02075337 FALSE FALSE
MSTRG.35076.1 ENSG00000101986 HEK293_DMSO_6hA HEK293_OSMI2_6hA ABCD1 protein_coding   6.871685 8.442842 11.83428 1.192634 1.531113 0.4866818 0.3370611 0.5315972 0.189634 0.2658593 0.1896340 -1.43986254 0.05263333 0.05566667 0.0150 -0.04066667 0.65546122 0.02075337 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000101986 E001 1.817082 0.0124225014 7.670833e-01 0.9385646 X 153724144 153724206 63 + 0.453 0.404 -0.262
ENSG00000101986 E002 169.418780 0.0002815854 1.471681e-02 0.2068279 X 153724856 153725712 857 + 2.255 2.191 -0.215
ENSG00000101986 E003 59.245001 0.0064942553 7.092300e-01 0.9184058 X 153725713 153725816 104 + 1.768 1.791 0.077
ENSG00000101986 E004 130.113999 0.0002532690 9.086105e-01 0.9781521 X 153725817 153726166 350 + 2.113 2.116 0.011
ENSG00000101986 E005 98.957557 0.0005010198 6.807710e-01 0.9084677 X 153729232 153729412 181 + 2.004 1.990 -0.049
ENSG00000101986 E006 42.350656 0.0008045193 6.784257e-05 0.0108713 X 153729413 153729897 485 + 1.522 1.735 0.724
ENSG00000101986 E007 2.030409 0.2655929438 7.676312e-02 0.4108130 X 153735344 153735427 84 + 0.261 0.647 2.062
ENSG00000101986 E008 80.264425 0.0018409410 5.559783e-01 0.8564114 X 153736112 153736254 143 + 1.916 1.893 -0.078
ENSG00000101986 E009 94.821945 0.0004330251 9.185996e-01 0.9804191 X 153736345 153736513 169 + 1.973 1.978 0.014
ENSG00000101986 E010 61.455844 0.0004902022 3.676156e-01 0.7519128 X 153737157 153737251 95 + 1.811 1.770 -0.137
ENSG00000101986 E011 75.876497 0.0053976566 8.532955e-01 0.9636207 X 153740092 153740237 146 + 1.884 1.877 -0.025
ENSG00000101986 E012 77.604398 0.0021138708 6.615917e-01 0.9010928 X 153740574 153740719 146 + 1.883 1.902 0.064
ENSG00000101986 E013 66.063251 0.0015551453 9.328599e-01 0.9841430 X 153742987 153743071 85 + 1.819 1.816 -0.009
ENSG00000101986 E014 79.109695 0.0026748423 8.439958e-01 0.9613058 X 153743221 153743346 126 + 1.891 1.902 0.036
ENSG00000101986 E015 259.261041 0.0001605224 5.199076e-01 0.8400535 X 153743489 153744755 1267 + 2.405 2.418 0.043