ENSG00000101773

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000327155 ENSG00000101773 HEK293_DMSO_6hA HEK293_OSMI2_6hA RBBP8 protein_coding protein_coding 23.20563 8.370207 9.813991 2.866227 2.184807 0.2293233 11.3725242 3.0611076 2.9804253 1.2279767 0.6083673 -0.0384084 0.42500000 0.35536667 0.3070667 -0.04830000 0.74957775 0.01875267 FALSE TRUE
ENST00000399722 ENSG00000101773 HEK293_DMSO_6hA HEK293_OSMI2_6hA RBBP8 protein_coding protein_coding 23.20563 8.370207 9.813991 2.866227 2.184807 0.2293233 0.8147054 0.6902209 1.6307531 0.4407905 0.5124815 1.2284761 0.06347500 0.06816667 0.1579667 0.08980000 0.59135477 0.01875267 FALSE TRUE
ENST00000581687 ENSG00000101773 HEK293_DMSO_6hA HEK293_OSMI2_6hA RBBP8 protein_coding protein_coding 23.20563 8.370207 9.813991 2.866227 2.184807 0.2293233 0.3428024 1.8068668 0.1452426 0.4248248 0.1452426 -3.5488559 0.04144583 0.23033333 0.0258000 -0.20453333 0.09329385 0.01875267 FALSE FALSE
ENST00000583057 ENSG00000101773 HEK293_DMSO_6hA HEK293_OSMI2_6hA RBBP8 protein_coding protein_coding 23.20563 8.370207 9.813991 2.866227 2.184807 0.2293233 2.1729411 1.4292400 2.2072595 0.4504695 0.5880418 0.6234705 0.15658333 0.17356667 0.2199333 0.04636667 0.72472236 0.01875267 FALSE TRUE
MSTRG.15575.10 ENSG00000101773 HEK293_DMSO_6hA HEK293_OSMI2_6hA RBBP8 protein_coding   23.20563 8.370207 9.813991 2.866227 2.184807 0.2293233 5.7708260 0.9068177 2.7408357 0.2252805 0.8187942 1.5851631 0.23010417 0.11463333 0.2765000 0.16186667 0.01875267 0.01875267 FALSE TRUE
MSTRG.15575.11 ENSG00000101773 HEK293_DMSO_6hA HEK293_OSMI2_6hA RBBP8 protein_coding   23.20563 8.370207 9.813991 2.866227 2.184807 0.2293233 1.8926216 0.0000000 0.0000000 0.0000000 0.0000000 0.0000000 0.05058750 0.00000000 0.0000000 0.00000000   0.01875267 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000101773 E001 0.0000000       18 22798261 22798487 227 +      
ENSG00000101773 E002 0.0000000       18 22911600 22911685 86 +      
ENSG00000101773 E003 0.0000000       18 22914121 22914122 2 +      
ENSG00000101773 E004 0.0000000       18 22914123 22914138 16 +      
ENSG00000101773 E005 0.0000000       18 22914139 22914306 168 +      
ENSG00000101773 E006 0.0000000       18 22915420 22915485 66 +      
ENSG00000101773 E007 0.0000000       18 22916941 22917026 86 +      
ENSG00000101773 E008 0.0000000       18 22929383 22929437 55 +      
ENSG00000101773 E009 0.4481873 0.0217681645 8.063663e-01   18 22933328 22933348 21 + 0.186 0.138 -0.511
ENSG00000101773 E010 15.6096051 0.0017502945 2.615711e-01 0.666821349 18 22933349 22933564 216 + 1.188 1.279 0.319
ENSG00000101773 E011 0.0000000       18 22933826 22933840 15 +      
ENSG00000101773 E012 0.1125166 0.0319734862 6.861020e-01   18 22933841 22933858 18 + 0.103 0.000 -8.466
ENSG00000101773 E013 0.6860885 0.0238914990 3.363135e-01   18 22933859 22933870 12 + 0.315 0.138 -1.504
ENSG00000101773 E014 0.7986051 0.0543217171 2.433758e-01   18 22933871 22933875 5 + 0.365 0.139 -1.811
ENSG00000101773 E015 1.8316852 0.0992643618 2.392251e-02 0.253999863 18 22933876 22933880 5 + 0.635 0.139 -3.143
ENSG00000101773 E016 17.8587009 0.0326501314 2.080438e-01 0.612100473 18 22933881 22934078 198 + 1.348 1.191 -0.551
ENSG00000101773 E017 11.7362136 0.0216160236 1.113036e-01 0.477912395 18 22934079 22934159 81 + 1.195 0.999 -0.711
ENSG00000101773 E018 0.6669020 0.0356410850 7.625698e-01   18 22934160 22934264 105 + 0.187 0.243 0.479
ENSG00000101773 E019 0.0000000       18 22934750 22934774 25 +      
ENSG00000101773 E020 57.8541298 0.0197246411 6.882630e-01 0.911288335 18 22936754 22936960 207 + 1.788 1.760 -0.094
ENSG00000101773 E021 0.4560530 0.4174739990 4.471977e-01   18 22937060 22937118 59 + 0.100 0.244 1.544
ENSG00000101773 E022 0.0000000       18 22946339 22946443 105 +      
ENSG00000101773 E023 29.2235960 0.0084756086 6.147832e-01 0.882196000 18 22946444 22946486 43 + 1.515 1.468 -0.161
ENSG00000101773 E024 36.6069067 0.0155191940 2.499923e-01 0.655671419 18 22949618 22949713 96 + 1.630 1.528 -0.350
ENSG00000101773 E025 0.0000000       18 22949714 22950035 322 +      
ENSG00000101773 E026 26.0059848 0.0046797874 2.414117e-02 0.254900545 18 22968806 22968841 36 + 1.513 1.342 -0.589
ENSG00000101773 E027 31.9813709 0.0025473977 2.139063e-01 0.618456103 18 22968842 22968918 77 + 1.564 1.486 -0.270
ENSG00000101773 E028 21.4052085 0.0016099595 8.435745e-01 0.961184056 18 22975153 22975180 28 + 1.374 1.357 -0.060
ENSG00000101773 E029 24.4882089 0.0015031925 9.670140e-01 0.992453460 18 22975181 22975219 39 + 1.425 1.417 -0.027
ENSG00000101773 E030 0.2842848 0.0296833706 7.856695e-01   18 22977790 22977887 98 + 0.103 0.138 0.493
ENSG00000101773 E031 52.8484071 0.0005820560 6.489154e-01 0.896034161 18 22982218 22982393 176 + 1.751 1.725 -0.085
ENSG00000101773 E032 45.7951523 0.0058297183 4.440206e-01 0.800032356 18 22984886 22984990 105 + 1.693 1.657 -0.125
ENSG00000101773 E033 35.6868761 0.0012189708 2.362297e-01 0.641181213 18 22989221 22989271 51 + 1.602 1.531 -0.242
ENSG00000101773 E034 34.7852805 0.0009384925 2.076824e-01 0.611612853 18 22989272 22989318 47 + 1.591 1.512 -0.268
ENSG00000101773 E035 51.6556071 0.0005624707 7.096980e-01 0.918562521 18 22990937 22991049 113 + 1.725 1.738 0.043
ENSG00000101773 E036 158.9860175 0.0002278729 4.153480e-02 0.319031278 18 22992748 22993483 736 + 2.193 2.241 0.162
ENSG00000101773 E037 70.3782633 0.0175313951 9.817793e-01 0.995613012 18 22993484 22993639 156 + 1.853 1.859 0.019
ENSG00000101773 E038 65.1692213 0.0006553976 6.444606e-01 0.894083054 18 22993721 22993847 127 + 1.821 1.836 0.051
ENSG00000101773 E039 59.3073693 0.0080775530 9.702672e-01 0.993099727 18 22996374 22996462 89 + 1.789 1.775 -0.047
ENSG00000101773 E040 88.5707335 0.0043530281 7.052761e-01 0.917034849 18 22997620 22997734 115 + 1.964 1.942 -0.073
ENSG00000101773 E041 0.9668570 0.0187980504 2.151737e-01   18 23001571 23001585 15 + 0.186 0.398 1.490
ENSG00000101773 E042 99.5586075 0.0003807282 3.737435e-01 0.755699309 18 23001586 23001729 144 + 2.025 1.990 -0.117
ENSG00000101773 E043 71.1836745 0.0004258323 4.363955e-01 0.795488318 18 23006363 23006432 70 + 1.881 1.845 -0.121
ENSG00000101773 E044 2.2912192 0.0262895541 1.144374e-01 0.483285677 18 23016796 23016827 32 + 0.370 0.641 1.327
ENSG00000101773 E045 91.0145591 0.0004085124 7.293931e-01 0.925413936 18 23016828 23016924 97 + 1.968 1.977 0.029
ENSG00000101773 E046 89.8755452 0.0004447373 7.855957e-03 0.155360583 18 23022129 23022270 142 + 1.925 2.015 0.302
ENSG00000101773 E047 72.9138881 0.0014606058 3.674453e-05 0.007191876 18 23026143 23026488 346 + 1.791 1.961 0.571