ENSG00000100997

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000339157 ENSG00000100997 HEK293_DMSO_6hA HEK293_OSMI2_6hA ABHD12 protein_coding protein_coding 58.59731 55.24845 72.96689 5.352324 9.3533 0.4012446 34.719128 28.834168 51.562482 5.6602399 6.777368 0.8383219 0.59182500 0.51073333 0.70710000 0.19636667 6.580986e-02 1.214785e-12 FALSE TRUE
ENST00000491682 ENSG00000100997 HEK293_DMSO_6hA HEK293_OSMI2_6hA ABHD12 protein_coding protein_coding 58.59731 55.24845 72.96689 5.352324 9.3533 0.4012446 1.785478 3.205669 0.000000 1.6036264 0.000000 -8.3289751 0.04462083 0.06163333 0.00000000 -0.06163333 4.046914e-01 1.214785e-12 FALSE FALSE
ENST00000672258 ENSG00000100997 HEK293_DMSO_6hA HEK293_OSMI2_6hA ABHD12 protein_coding protein_coding 58.59731 55.24845 72.96689 5.352324 9.3533 0.4012446 3.465663 0.000000 4.368913 0.0000000 2.248521 8.7744291 0.04091250 0.00000000 0.05473333 0.05473333 1.214785e-12 1.214785e-12 FALSE TRUE
ENST00000673524 ENSG00000100997 HEK293_DMSO_6hA HEK293_OSMI2_6hA ABHD12 protein_coding nonsense_mediated_decay 58.59731 55.24845 72.96689 5.352324 9.3533 0.4012446 8.234453 9.929568 6.489051 0.8436674 2.351378 -0.6129541 0.12820833 0.18540000 0.08740000 -0.09800000 2.245851e-01 1.214785e-12 TRUE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000100997 E001 0.0000000       20 25294742 25294742 1 -      
ENSG00000100997 E002 1.0715080 0.0152132605 9.927721e-01   20 25294743 25294746 4 - 0.325 0.318 -0.044
ENSG00000100997 E003 52.9887765 0.0226710738 1.298851e-05 0.003682363 20 25294747 25295030 284 - 1.514 1.887 1.266
ENSG00000100997 E004 2.2482645 0.1149560557 8.166550e-01 0.953542968 20 25300213 25300213 1 - 0.537 0.502 -0.165
ENSG00000100997 E005 7.1931005 0.0637564203 5.108147e-01 0.835196985 20 25300214 25300216 3 - 0.978 0.856 -0.463
ENSG00000100997 E006 115.4931228 0.0067902749 6.998486e-01 0.915006820 20 25300217 25300254 38 - 2.072 2.056 -0.055
ENSG00000100997 E007 291.5691383 0.0004473165 2.448713e-01 0.650260010 20 25300255 25300365 111 - 2.481 2.448 -0.110
ENSG00000100997 E008 321.4087332 0.0022751333 4.226863e-01 0.787627538 20 25300366 25300428 63 - 2.522 2.492 -0.099
ENSG00000100997 E009 760.4019158 0.0010104085 4.175196e-02 0.319667748 20 25300429 25300698 270 - 2.900 2.857 -0.141
ENSG00000100997 E010 275.7282794 0.0037140329 1.397934e-01 0.524724875 20 25300699 25300702 4 - 2.463 2.413 -0.170
ENSG00000100997 E011 568.2051436 0.0022969829 5.709409e-03 0.134657044 20 25300703 25300832 130 - 2.788 2.712 -0.253
ENSG00000100997 E012 404.4977554 0.0005583961 7.650042e-02 0.410327235 20 25300833 25300884 52 - 2.626 2.583 -0.144
ENSG00000100997 E013 15.2089927 0.0068630302 6.732865e-01 0.905308816 20 25301249 25301294 46 - 1.184 1.218 0.123
ENSG00000100997 E014 17.4781967 0.0091648282 2.745447e-01 0.678394918 20 25301332 25301378 47 - 1.208 1.304 0.337
ENSG00000100997 E015 24.6373096 0.0537090786 4.372534e-02 0.325751164 20 25301719 25301833 115 - 1.266 1.522 0.887
ENSG00000100997 E016 35.8167473 0.0485337251 2.477040e-02 0.257653525 20 25301834 25302034 201 - 1.427 1.679 0.862
ENSG00000100997 E017 471.1394913 0.0001338893 3.917573e-01 0.768055312 20 25302219 25302276 58 - 2.679 2.659 -0.068
ENSG00000100997 E018 477.1522362 0.0001084661 4.736727e-02 0.337048375 20 25302277 25302346 70 - 2.663 2.689 0.087
ENSG00000100997 E019 8.3462454 0.0578494184 6.915509e-01 0.912300013 20 25303263 25303549 287 - 0.919 1.006 0.322
ENSG00000100997 E020 343.4452950 0.0021572064 7.571104e-01 0.934908240 20 25303550 25303577 28 - 2.530 2.537 0.024
ENSG00000100997 E021 439.8922261 0.0027607880 8.152587e-01 0.953047626 20 25303578 25303628 51 - 2.639 2.644 0.014
ENSG00000100997 E022 6.9517089 0.0053244088 3.184543e-03 0.101560332 20 25306299 25306540 242 - 0.691 1.045 1.369
ENSG00000100997 E023 467.9224825 0.0008740087 8.861853e-01 0.972777858 20 25306833 25306915 83 - 2.670 2.663 -0.024
ENSG00000100997 E024 428.2762520 0.0006016765 8.524672e-01 0.963489658 20 25307966 25308045 80 - 2.631 2.624 -0.024
ENSG00000100997 E025 352.7745706 0.0007151538 3.675004e-01 0.751819382 20 25308457 25308494 38 - 2.555 2.531 -0.079
ENSG00000100997 E026 394.3004531 0.0006750849 9.129052e-01 0.979187345 20 25309446 25309498 53 - 2.595 2.589 -0.020
ENSG00000100997 E027 431.8363172 0.0001221341 8.749920e-01 0.969846938 20 25309499 25309575 77 - 2.634 2.630 -0.013
ENSG00000100997 E028 7.6505781 0.0034148885 1.349244e-02 0.200140146 20 25310200 25310472 273 - 0.779 1.059 1.060
ENSG00000100997 E029 282.2750961 0.0001408545 2.414087e-01 0.646459785 20 25314925 25314970 46 - 2.440 2.458 0.060
ENSG00000100997 E030 290.1864384 0.0001757733 3.436450e-02 0.295220662 20 25317048 25317078 31 - 2.442 2.480 0.129
ENSG00000100997 E031 3.9149403 0.0057144284 6.368887e-01 0.891128591 20 25319052 25319155 104 - 0.665 0.727 0.258
ENSG00000100997 E032 0.6574601 0.1252732968 2.287569e-01   20 25319773 25319825 53 - 0.108 0.317 1.934
ENSG00000100997 E033 445.5924861 0.0001378973 8.021185e-03 0.156521735 20 25320199 25320318 120 - 2.628 2.667 0.128
ENSG00000100997 E034 439.3674990 0.0001167954 1.399158e-02 0.202712924 20 25323325 25323430 106 - 2.623 2.658 0.117
ENSG00000100997 E035 8.6915508 0.0602649953 3.611490e-01 0.747575251 20 25338885 25339004 120 - 1.069 0.895 -0.645
ENSG00000100997 E036 2.8286853 0.0075914144 2.091349e-01 0.613337960 20 25339220 25339226 7 - 0.470 0.663 0.884
ENSG00000100997 E037 338.9870085 0.0001487811 1.198394e-03 0.059950990 20 25339227 25339351 125 - 2.500 2.556 0.189
ENSG00000100997 E038 0.0000000       20 25339622 25339694 73 -      
ENSG00000100997 E039 0.2920894 0.0268742815 8.398914e-01   20 25339695 25339749 55 - 0.107 0.134 0.375
ENSG00000100997 E040 0.0000000       20 25341946 25342096 151 -      
ENSG00000100997 E041 3.0632504 0.0143867340 2.515742e-01 0.657551439 20 25389926 25390387 462 - 0.690 0.500 -0.849
ENSG00000100997 E042 164.5685918 0.0081433331 4.013827e-01 0.774278584 20 25390513 25390839 327 - 2.234 2.199 -0.116