ENSG00000100796

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000554308 ENSG00000100796 HEK293_DMSO_6hA HEK293_OSMI2_6hA PPP4R3A protein_coding nonsense_mediated_decay 39.44954 18.78083 26.96786 4.856397 6.86089 0.5217478 2.275122 1.0267005 1.722968 0.4197752 0.4336638 0.74124623 0.05142917 0.05116667 0.06393333 0.01276667 0.74957775 0.02758599 TRUE TRUE
ENST00000554684 ENSG00000100796 HEK293_DMSO_6hA HEK293_OSMI2_6hA PPP4R3A protein_coding protein_coding 39.44954 18.78083 26.96786 4.856397 6.86089 0.5217478 9.533568 4.9323946 6.714330 1.1016077 2.2548235 0.44418040 0.25192917 0.26690000 0.23360000 -0.03330000 0.75505080 0.02758599 FALSE TRUE
ENST00000554943 ENSG00000100796 HEK293_DMSO_6hA HEK293_OSMI2_6hA PPP4R3A protein_coding protein_coding 39.44954 18.78083 26.96786 4.856397 6.86089 0.5217478 3.029153 1.1177156 4.148686 0.2579934 0.9947791 1.88272461 0.08920000 0.06243333 0.15656667 0.09413333 0.02758599 0.02758599 FALSE TRUE
ENST00000555718 ENSG00000100796 HEK293_DMSO_6hA HEK293_OSMI2_6hA PPP4R3A protein_coding processed_transcript 39.44954 18.78083 26.96786 4.856397 6.86089 0.5217478 2.342280 1.4721668 1.559943 0.6418107 0.4459660 0.08300426 0.06099167 0.07223333 0.05700000 -0.01523333 0.75317231 0.02758599 FALSE FALSE
ENST00000557382 ENSG00000100796 HEK293_DMSO_6hA HEK293_OSMI2_6hA PPP4R3A protein_coding retained_intron 39.44954 18.78083 26.96786 4.856397 6.86089 0.5217478 11.208944 8.9638994 9.920751 1.8282776 2.6431910 0.14616775 0.33355833 0.48966667 0.36906667 -0.12060000 0.19925195 0.02758599   FALSE
MSTRG.10089.4 ENSG00000100796 HEK293_DMSO_6hA HEK293_OSMI2_6hA PPP4R3A protein_coding   39.44954 18.78083 26.96786 4.856397 6.86089 0.5217478 6.072744 0.3133399 2.452519 0.2386018 0.6430918 2.92901151 0.11628333 0.01303333 0.09680000 0.08376667 0.06627841 0.02758599 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000100796 E001 1.9172934 0.0102798240 0.343730162 0.73486672 14 91457508 91457610 103 - 0.508 0.347 -0.857
ENSG00000100796 E002 112.1467895 0.0123666763 0.256828783 0.66264193 14 91457611 91458138 528 - 2.018 2.086 0.227
ENSG00000100796 E003 169.8741292 0.0032442465 0.031896619 0.28680649 14 91458139 91458329 191 - 2.195 2.276 0.269
ENSG00000100796 E004 422.6549231 0.0016613347 0.001498357 0.06826814 14 91458330 91458858 529 - 2.590 2.671 0.271
ENSG00000100796 E005 95.9894436 0.0031746190 0.052500021 0.35141224 14 91458859 91458869 11 - 1.947 2.043 0.321
ENSG00000100796 E006 229.5043470 0.0006591727 0.427191295 0.79045835 14 91461381 91461607 227 - 2.355 2.381 0.089
ENSG00000100796 E007 2.1138247 0.0317884096 0.036908982 0.30352037 14 91461608 91461684 77 - 0.298 0.669 1.890
ENSG00000100796 E008 73.6889953 0.0047434994 0.337271784 0.72993548 14 91462049 91462053 5 - 1.895 1.851 -0.149
ENSG00000100796 E009 208.8173438 0.0009769048 0.841127659 0.96069418 14 91462054 91462221 168 - 2.324 2.325 0.001
ENSG00000100796 E010 97.2526614 0.0009029928 0.672871820 0.90514796 14 91462222 91462239 18 - 2.001 1.990 -0.036
ENSG00000100796 E011 174.3805571 0.0001961410 0.978498931 0.99484557 14 91462735 91462877 143 - 2.242 2.250 0.027
ENSG00000100796 E012 134.7548839 0.0030283781 0.917473344 0.98026127 14 91465250 91465419 170 - 2.123 2.133 0.035
ENSG00000100796 E013 9.7471867 0.0113275800 0.078658308 0.41491315 14 91466261 91466416 156 - 0.935 1.147 0.774
ENSG00000100796 E014 1.4944931 0.0512241776 0.028481139   14 91468964 91469003 40 - 0.175 0.585 2.523
ENSG00000100796 E015 0.4437478 0.0219996637 0.886267464   14 91470210 91470247 38 - 0.174 0.149 -0.268
ENSG00000100796 E016 107.9039515 0.0003243994 0.498741692 0.82893008 14 91470837 91470995 159 - 2.044 2.028 -0.052
ENSG00000100796 E017 89.0339568 0.0004130565 0.392746633 0.76872262 14 91473033 91473135 103 - 1.942 1.981 0.131
ENSG00000100796 E018 91.2279430 0.0003283973 0.170468505 0.56760437 14 91473239 91473348 110 - 1.984 1.940 -0.147
ENSG00000100796 E019 48.2801132 0.0005843663 0.729439531 0.92541394 14 91473349 91473370 22 - 1.698 1.688 -0.035
ENSG00000100796 E020 21.0341548 0.1446952409 0.063442534 0.38051881 14 91474641 91475810 1170 - 1.144 1.516 1.301
ENSG00000100796 E021 16.9016180 0.0471616358 0.222264729 0.62687818 14 91475811 91475819 9 - 1.288 1.178 -0.385
ENSG00000100796 E022 20.4607195 0.0027262517 0.090611097 0.43978309 14 91475820 91475849 30 - 1.374 1.249 -0.437
ENSG00000100796 E023 90.5735756 0.0009990175 0.042331414 0.32143593 14 91475850 91475966 117 - 1.986 1.915 -0.240
ENSG00000100796 E024 73.1391714 0.0005282758 0.179065544 0.57800372 14 91476408 91476479 72 - 1.888 1.837 -0.169
ENSG00000100796 E025 53.7361161 0.0010074969 0.606400077 0.87822625 14 91476480 91476524 45 - 1.741 1.723 -0.062
ENSG00000100796 E026 72.8551000 0.0011085629 0.147971636 0.53635996 14 91476909 91476986 78 - 1.888 1.832 -0.191
ENSG00000100796 E027 204.4093727 0.0002068282 0.023086896 0.25050114 14 91481576 91482039 464 - 2.332 2.282 -0.165
ENSG00000100796 E028 104.7221266 0.0003345980 0.113035152 0.48095884 14 91482040 91482193 154 - 2.043 1.994 -0.165
ENSG00000100796 E029 75.3093010 0.0024135946 0.370564106 0.75382472 14 91485632 91485730 99 - 1.889 1.857 -0.108
ENSG00000100796 E030 51.5738642 0.0009406357 0.372499173 0.75505863 14 91490747 91490802 56 - 1.735 1.699 -0.123
ENSG00000100796 E031 56.6214284 0.0009731079 0.200155334 0.60362787 14 91509506 91509704 199 - 1.780 1.726 -0.181
ENSG00000100796 E032 46.0233621 0.0099774353 0.149257283 0.53840084 14 91509705 91510074 370 - 1.705 1.622 -0.279
ENSG00000100796 E033 62.2777481 0.0121477184 0.041307825 0.31832204 14 91510075 91510507 433 - 1.847 1.723 -0.418
ENSG00000100796 E034 2.6273290 0.0413129248 0.023726372 0.25337354 14 91510529 91510554 26 - 0.672 0.259 -2.180