ENSG00000100596

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000216484 ENSG00000100596 HEK293_DMSO_6hA HEK293_OSMI2_6hA SPTLC2 protein_coding protein_coding 14.20915 8.774297 7.91562 1.470793 1.381262 -0.1484032 6.148336 5.181454 3.107993 1.0054598 0.2969277 -0.7355213 0.4418583 0.5855333 0.4277333 -0.157800000 0.492288839 0.001040301 FALSE TRUE
ENST00000692906 ENSG00000100596 HEK293_DMSO_6hA HEK293_OSMI2_6hA SPTLC2 protein_coding processed_transcript 14.20915 8.774297 7.91562 1.470793 1.381262 -0.1484032 3.291942 1.600716 1.795299 0.2359960 1.1006582 0.1645357 0.2193792 0.1860333 0.1892000 0.003166667 0.859365560 0.001040301 FALSE TRUE
MSTRG.9985.5 ENSG00000100596 HEK293_DMSO_6hA HEK293_OSMI2_6hA SPTLC2 protein_coding   14.20915 8.774297 7.91562 1.470793 1.381262 -0.1484032 4.648424 1.650693 2.982650 0.2317234 0.4863603 0.8496382 0.3291750 0.1901667 0.3784333 0.188266667 0.001040301 0.001040301 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000100596 E001 1.4005391 0.0120143243 5.876039e-01   14 77505997 77506002 6 - 0.317 0.428 0.642
ENSG00000100596 E002 1048.2004593 0.0013982613 1.612317e-08 2.364384e-05 14 77506003 77512340 6338 - 2.955 3.049 0.314
ENSG00000100596 E003 77.9959751 0.0004246530 9.595659e-01 9.906618e-01 14 77512341 77512403 63 - 1.877 1.901 0.082
ENSG00000100596 E004 114.4361510 0.0003412640 2.919365e-01 6.929242e-01 14 77518038 77518167 130 - 2.060 2.052 -0.028
ENSG00000100596 E005 114.7479257 0.0003928802 8.067454e-03 1.568152e-01 14 77521446 77521581 136 - 2.089 2.028 -0.204
ENSG00000100596 E006 0.1717682 0.0366757033 6.474776e-01   14 77521582 77521615 34 - 0.000 0.107 9.958
ENSG00000100596 E007 0.0000000       14 77535600 77536005 406 -      
ENSG00000100596 E008 61.3088000 0.0014322313 1.328852e-01 5.145119e-01 14 77552096 77552119 24 - 1.813 1.768 -0.152
ENSG00000100596 E009 93.7828898 0.0003214440 2.916185e-01 6.927794e-01 14 77552120 77552222 103 - 1.975 1.963 -0.038
ENSG00000100596 E010 0.1717682 0.0366757033 6.474776e-01   14 77554758 77554965 208 - 0.000 0.107 9.958
ENSG00000100596 E011 54.6695070 0.0037502736 2.266867e-01 6.316467e-01 14 77555300 77555319 20 - 1.760 1.722 -0.127
ENSG00000100596 E012 115.1308832 0.0002551148 6.896594e-02 3.935990e-01 14 77555320 77555519 200 - 2.076 2.044 -0.107
ENSG00000100596 E013 76.9770478 0.0004920668 1.769456e-02 2.245214e-01 14 77557041 77557146 106 - 1.926 1.858 -0.228
ENSG00000100596 E014 0.6652648 0.0204051350 4.847832e-01   14 77557147 77557321 175 - 0.133 0.265 1.223
ENSG00000100596 E015 75.2615186 0.0005622898 2.569913e-02 2.609422e-01 14 77562396 77562489 94 - 1.914 1.851 -0.214
ENSG00000100596 E016 0.6351502 0.0599881839 8.376969e-02   14 77568984 77570383 1400 - 0.000 0.325 11.750
ENSG00000100596 E017 82.6219383 0.0017477776 1.719473e-02 2.218234e-01 14 77570384 77570508 125 - 1.959 1.885 -0.248
ENSG00000100596 E018 0.6026480 0.0259528697 7.565065e-01   14 77570509 77571010 502 - 0.235 0.193 -0.361
ENSG00000100596 E019 1.0059989 0.2319025394 7.324442e-01   14 77575732 77576766 1035 - 0.240 0.325 0.591
ENSG00000100596 E020 84.1436251 0.0004810347 1.364850e-02 2.009668e-01 14 77576767 77576915 149 - 1.958 1.890 -0.229
ENSG00000100596 E021 0.3968013 0.1052552294 4.440231e-01   14 77576916 77577160 245 - 0.232 0.107 -1.333
ENSG00000100596 E022 0.1767706 0.0404311327 3.615623e-01   14 77578766 77578954 189 - 0.134 0.000 -11.032
ENSG00000100596 E023 66.1134352 0.0014764320 7.211716e-01 9.226461e-01 14 77578955 77579109 155 - 1.812 1.823 0.034
ENSG00000100596 E024 0.0000000       14 77588871 77588929 59 -      
ENSG00000100596 E025 64.4433231 0.0013543309 1.936001e-01 5.958301e-01 14 77597186 77597380 195 - 1.827 1.794 -0.110
ENSG00000100596 E026 46.0546950 0.0057036676 5.476985e-02 3.576411e-01 14 77616448 77616767 320 - 1.718 1.627 -0.310