ENSG00000100554

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000216442 ENSG00000100554 HEK293_DMSO_6hA HEK293_OSMI2_6hA ATP6V1D protein_coding protein_coding 32.03784 12.04441 11.74866 2.92408 1.493972 -0.03583637 24.472907 10.53013 9.057892 2.152466 1.2868316 -0.2170534 0.79843333 0.8890333 0.7690000 -0.1200333 2.554851e-01 2.425779e-12 FALSE TRUE
ENST00000554236 ENSG00000100554 HEK293_DMSO_6hA HEK293_OSMI2_6hA ATP6V1D protein_coding protein_coding 32.03784 12.04441 11.74866 2.92408 1.493972 -0.03583637 3.227962 0.00000 1.580296 0.000000 0.3219626 7.3131516 0.08044583 0.0000000 0.1361333 0.1361333 2.425779e-12 2.425779e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000100554 E001 0.1717682 0.0365313389 0.550261595   14 67284499 67284545 47 - 0.000 0.113 9.958
ENSG00000100554 E002 0.0000000       14 67294371 67294987 617 -      
ENSG00000100554 E003 0.0000000       14 67304012 67304059 48 -      
ENSG00000100554 E004 0.0000000       14 67304060 67304077 18 -      
ENSG00000100554 E005 0.3312313 0.0267643820 0.911425391   14 67312005 67312057 53 - 0.127 0.113 -0.193
ENSG00000100554 E006 0.0000000       14 67312058 67312086 29 -      
ENSG00000100554 E007 0.2892872 0.0274424043 0.166356097   14 67312087 67312183 97 - 0.224 0.000 -11.506
ENSG00000100554 E008 4.3342045 0.0057398989 0.985684582 0.99650568 14 67336188 67336646 459 - 0.732 0.736 0.018
ENSG00000100554 E009 2.2297674 0.0084523392 0.183529164 0.58374315 14 67336647 67336677 31 - 0.372 0.598 1.133
ENSG00000100554 E010 2.9651291 0.0149684470 0.224489988 0.62935210 14 67336678 67336738 61 - 0.481 0.686 0.924
ENSG00000100554 E011 2.2810269 0.0092045047 0.421698116 0.78714923 14 67337387 67337509 123 - 0.570 0.444 -0.608
ENSG00000100554 E012 1.8547673 0.0432837761 0.196884210 0.60015242 14 67337510 67337776 267 - 0.568 0.340 -1.182
ENSG00000100554 E013 11.1540255 0.0024492392 0.805947826 0.95000500 14 67337872 67338070 199 - 1.086 1.068 -0.065
ENSG00000100554 E014 4.7746726 0.0088568251 0.468431313 0.81317540 14 67338071 67338074 4 - 0.807 0.712 -0.382
ENSG00000100554 E015 34.4239357 0.0098662882 0.933256254 0.98418843 14 67338075 67338152 78 - 1.537 1.545 0.027
ENSG00000100554 E016 75.9219393 0.0129826237 0.359994041 0.74687315 14 67338153 67338250 98 - 1.851 1.902 0.170
ENSG00000100554 E017 135.6079555 0.0103060366 0.079577888 0.41681488 14 67338251 67338498 248 - 2.082 2.168 0.286
ENSG00000100554 E018 57.8000561 0.0042277358 0.021137424 0.24103092 14 67338499 67338554 56 - 1.695 1.822 0.431
ENSG00000100554 E019 41.5399245 0.0010687855 0.042150572 0.32079497 14 67338555 67338560 6 - 1.562 1.680 0.401
ENSG00000100554 E020 122.8740991 0.0010641050 0.038521953 0.30908025 14 67338561 67338762 202 - 2.048 2.125 0.258
ENSG00000100554 E021 86.6793461 0.0004791259 0.200904117 0.60439070 14 67340440 67340518 79 - 1.908 1.964 0.188
ENSG00000100554 E022 71.2038100 0.0009488846 0.718966058 0.92183349 14 67343372 67343438 67 - 1.845 1.869 0.079
ENSG00000100554 E023 102.0863159 0.0003150706 0.065948527 0.38664960 14 67345768 67345871 104 - 2.038 1.983 -0.182
ENSG00000100554 E024 81.2281366 0.0014170323 0.162912144 0.55768811 14 67347409 67347453 45 - 1.935 1.884 -0.170
ENSG00000100554 E025 0.3535412 0.4825163671 0.275501579   14 67348855 67349036 182 - 0.233 0.000 -11.579
ENSG00000100554 E026 96.5454437 0.0039611111 0.211213849 0.61560661 14 67349037 67349104 68 - 2.010 1.962 -0.162
ENSG00000100554 E027 62.2553997 0.0013377437 0.016188479 0.21592636 14 67350611 67350617 7 - 1.849 1.747 -0.344
ENSG00000100554 E028 64.4942514 0.0005366360 0.002832181 0.09554516 14 67350618 67350631 14 - 1.874 1.754 -0.405
ENSG00000100554 E029 82.9848757 0.0003707692 0.199662678 0.60298546 14 67350632 67350690 59 - 1.943 1.903 -0.135
ENSG00000100554 E030 0.4856919 0.0582274282 0.682294481   14 67352731 67352922 192 - 0.127 0.202 0.801
ENSG00000100554 E031 102.1953854 0.0003206312 0.335839915 0.72879369 14 67352923 67353040 118 - 2.025 2.000 -0.083
ENSG00000100554 E032 0.0000000       14 67353699 67353959 261 -      
ENSG00000100554 E033 82.9354031 0.0003973743 0.607275776 0.87859411 14 67359658 67359860 203 - 1.926 1.914 -0.041
ENSG00000100554 E034 0.9445471 0.0155083091 0.130396333   14 67359963 67360063 101 - 0.126 0.395 2.135
ENSG00000100554 E035 0.8698591 0.2961182829 0.698768173   14 67360064 67360105 42 - 0.316 0.202 -0.856
ENSG00000100554 E036 1.3929683 0.3126986367 0.612917672   14 67360106 67360209 104 - 0.316 0.396 0.476
ENSG00000100554 E037 0.8587799 0.0171031627 0.224935106   14 67360210 67360313 104 - 0.127 0.340 1.809