ENSG00000100504

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000216392 ENSG00000100504 HEK293_DMSO_6hA HEK293_OSMI2_6hA PYGL protein_coding protein_coding 123.9956 60.15146 83.54533 11.09874 17.5485 0.4738922 83.31077 35.58516 62.46506 6.519498 14.514547 0.8115995 0.6676208 0.5930667 0.7390333 0.1459667 0.00105376 0.00105376 FALSE TRUE
ENST00000530336 ENSG00000100504 HEK293_DMSO_6hA HEK293_OSMI2_6hA PYGL protein_coding retained_intron 123.9956 60.15146 83.54533 11.09874 17.5485 0.4738922 23.83248 14.85646 12.23376 1.616994 1.482334 -0.2800139 0.1983625 0.2576000 0.1559333 -0.1016667 0.22028524 0.00105376 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000100504 E001 1.035551 0.0166054380 0.2092178583   14 50857891 50858169 279 - 0.181 0.408 1.591
ENSG00000100504 E002 1.468068 0.0651633388 0.8811122092   14 50905207 50905216 10 - 0.363 0.407 0.248
ENSG00000100504 E003 1.376224 0.0404690200 0.6478917445   14 50905217 50905217 1 - 0.310 0.408 0.577
ENSG00000100504 E004 6.057242 0.0040298653 0.9649133237 0.99194644 14 50905218 50905221 4 - 0.841 0.859 0.071
ENSG00000100504 E005 705.201078 0.0038106356 0.4539596474 0.80559639 14 50905222 50905556 335 - 2.847 2.844 -0.012
ENSG00000100504 E006 4.269619 0.0072852727 0.0048451014 0.12480599 14 50908142 50908270 129 - 0.487 0.903 1.761
ENSG00000100504 E007 420.758229 0.0045414248 0.3651647782 0.75037725 14 50908271 50908337 67 - 2.627 2.616 -0.038
ENSG00000100504 E008 627.593740 0.0029600163 0.7204091517 0.92235213 14 50908821 50908955 135 - 2.792 2.802 0.035
ENSG00000100504 E009 814.501834 0.0011522709 0.2939156644 0.69454361 14 50909895 50910102 208 - 2.913 2.909 -0.010
ENSG00000100504 E010 606.726705 0.0001096021 0.1466871718 0.53459353 14 50911730 50911871 142 - 2.789 2.783 -0.018
ENSG00000100504 E011 412.941797 0.0009817697 0.7877228726 0.94447561 14 50911978 50912036 59 - 2.612 2.626 0.045
ENSG00000100504 E012 450.479622 0.0001483316 0.5482891122 0.85331243 14 50912156 50912222 67 - 2.656 2.662 0.020
ENSG00000100504 E013 415.367479 0.0002303520 0.5818141689 0.86755131 14 50912223 50912303 81 - 2.621 2.627 0.019
ENSG00000100504 E014 435.130956 0.0001752104 0.0733634756 0.40302055 14 50913029 50913130 102 - 2.650 2.635 -0.052
ENSG00000100504 E015 432.480548 0.0017157638 0.0911764151 0.44054324 14 50914701 50914815 115 - 2.648 2.623 -0.082
ENSG00000100504 E016 1.041718 0.0232716219 0.0364822040   14 50915190 50915335 146 - 0.100 0.470 2.915
ENSG00000100504 E017 478.476466 0.0014040847 0.4396869553 0.79755684 14 50915336 50915499 164 - 2.681 2.682 0.005
ENSG00000100504 E018 364.515919 0.0001452578 0.1268955031 0.50559574 14 50915825 50915971 147 - 2.572 2.559 -0.044
ENSG00000100504 E019 330.312527 0.0004654738 0.0005627781 0.03872816 14 50916642 50916734 93 - 2.548 2.489 -0.195
ENSG00000100504 E020 282.288980 0.0001735524 0.0005823871 0.03967742 14 50916962 50917015 54 - 2.481 2.422 -0.195
ENSG00000100504 E021 346.683702 0.0002381102 0.0143844102 0.20489332 14 50917016 50917105 90 - 2.558 2.526 -0.107
ENSG00000100504 E022 340.648542 0.0001581207 0.0145598124 0.20601087 14 50920541 50920623 83 - 2.551 2.519 -0.106
ENSG00000100504 E023 365.253564 0.0015500064 0.0018360870 0.07627379 14 50920956 50921067 112 - 2.590 2.529 -0.202
ENSG00000100504 E024 28.517494 0.0478913806 0.0091459388 0.16674710 14 50921068 50921528 461 - 1.276 1.629 1.215
ENSG00000100504 E025 192.757705 0.0313403924 0.0015509003 0.06941620 14 50923237 50923659 423 - 2.116 2.436 1.070
ENSG00000100504 E026 211.333501 0.0357737154 0.0064150244 0.14147289 14 50923660 50923932 273 - 2.169 2.467 0.997
ENSG00000100504 E027 115.623067 0.0314938498 0.0029098077 0.09678430 14 50923933 50923968 36 - 1.904 2.209 1.022
ENSG00000100504 E028 547.096408 0.0020588480 0.3547151790 0.74310105 14 50923969 50924100 132 - 2.716 2.762 0.156
ENSG00000100504 E029 450.069844 0.0035766552 0.2539153164 0.65966813 14 50931673 50931776 104 - 2.624 2.685 0.202
ENSG00000100504 E030 385.545891 0.0041483685 0.0677749737 0.39076313 14 50935107 50935185 79 - 2.544 2.632 0.291
ENSG00000100504 E031 351.335977 0.0071860991 0.2951581807 0.69563314 14 50937736 50937837 102 - 2.511 2.582 0.239
ENSG00000100504 E032 3.295764 0.0067426199 0.6501139006 0.89645864 14 50941047 50941107 61 - 0.611 0.690 0.335
ENSG00000100504 E033 444.014620 0.0051934520 0.7694414070 0.93933435 14 50944161 50944442 282 - 2.630 2.664 0.113
ENSG00000100504 E034 105.888402 0.0008083227 0.7315465989 0.92620724 14 50944443 50944483 41 - 2.026 2.031 0.017
ENSG00000100504 E035 0.000000       14 50944884 50944910 27 -