ENSG00000100413

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000337566 ENSG00000100413 HEK293_DMSO_6hA HEK293_OSMI2_6hA POLR3H protein_coding protein_coding 104.4041 84.84358 140.0211 9.3391 28.139 0.7226995 23.821465 18.012910 35.810566 2.3208728 9.869819 0.9909561 0.21114167 0.21130000 0.2470667 0.035766667 0.72671297 0.03627836 FALSE TRUE
ENST00000355209 ENSG00000100413 HEK293_DMSO_6hA HEK293_OSMI2_6hA POLR3H protein_coding protein_coding 104.4041 84.84358 140.0211 9.3391 28.139 0.7226995 11.562796 5.920155 18.036016 0.0843306 4.850049 1.6055386 0.11621250 0.07153333 0.1249667 0.053433333 0.03627836 0.03627836 FALSE TRUE
ENST00000396504 ENSG00000100413 HEK293_DMSO_6hA HEK293_OSMI2_6hA POLR3H protein_coding protein_coding 104.4041 84.84358 140.0211 9.3391 28.139 0.7226995 26.926913 23.039036 31.348091 3.4076574 3.430279 0.4441313 0.25380000 0.26910000 0.2353667 -0.033733333 0.73078313 0.03627836 FALSE TRUE
ENST00000407461 ENSG00000100413 HEK293_DMSO_6hA HEK293_OSMI2_6hA POLR3H protein_coding protein_coding 104.4041 84.84358 140.0211 9.3391 28.139 0.7226995 9.419414 5.184148 17.497951 1.1946325 7.269306 1.7530513 0.09886667 0.06126667 0.1152333 0.053966667 0.43054751 0.03627836 FALSE TRUE
ENST00000431534 ENSG00000100413 HEK293_DMSO_6hA HEK293_OSMI2_6hA POLR3H protein_coding nonsense_mediated_decay 104.4041 84.84358 140.0211 9.3391 28.139 0.7226995 19.366165 15.013011 24.940813 1.0671933 4.980893 0.7319128 0.19078333 0.17873333 0.1803000 0.001566667 0.99562481 0.03627836 FALSE TRUE
MSTRG.22207.8 ENSG00000100413 HEK293_DMSO_6hA HEK293_OSMI2_6hA POLR3H protein_coding   104.4041 84.84358 140.0211 9.3391 28.139 0.7226995 7.075171 8.915474 6.649264 4.8880700 3.874007 -0.4225662 0.06027500 0.10820000 0.0521000 -0.056100000 0.94689404 0.03627836 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000100413 E001 8.5425423 2.782749e-03 0.1274723301 0.50639638 22 41525799 41525803 5 - 0.898 1.064 0.616
ENSG00000100413 E002 3197.9324542 2.882085e-03 0.8283958357 0.95651575 22 41525804 41528841 3038 - 3.490 3.512 0.074
ENSG00000100413 E003 129.7167103 2.411346e-03 0.9628395630 0.99149137 22 41528842 41528842 1 - 2.107 2.113 0.020
ENSG00000100413 E004 204.8731687 1.633070e-03 0.3922865082 0.76836625 22 41528843 41528864 22 - 2.292 2.324 0.106
ENSG00000100413 E005 1520.7700899 6.003705e-05 0.5672916204 0.86101300 22 41528865 41529211 347 - 3.174 3.181 0.023
ENSG00000100413 E006 937.3077226 7.460886e-05 0.1513853906 0.54122808 22 41529212 41529301 90 - 2.974 2.958 -0.052
ENSG00000100413 E007 545.4385598 9.413214e-05 0.0588300726 0.36854198 22 41529302 41529304 3 - 2.744 2.716 -0.094
ENSG00000100413 E008 618.8454973 8.733964e-05 0.1119296421 0.47917095 22 41529305 41529336 32 - 2.796 2.774 -0.073
ENSG00000100413 E009 1322.4129541 1.413684e-04 0.9606542885 0.99096294 22 41530687 41530888 202 - 3.116 3.118 0.006
ENSG00000100413 E010 604.3236152 1.467142e-03 0.2460772510 0.65166339 22 41532094 41532118 25 - 2.765 2.794 0.097
ENSG00000100413 E011 616.9666570 8.519388e-04 0.0787778789 0.41497241 22 41532119 41532157 39 - 2.770 2.807 0.125
ENSG00000100413 E012 46.3892034 1.134876e-02 0.8087569969 0.95105107 22 41532604 41532624 21 - 1.661 1.683 0.074
ENSG00000100413 E013 50.6757317 5.926096e-03 0.4355235521 0.79468210 22 41532625 41532658 34 - 1.690 1.740 0.169
ENSG00000100413 E014 695.4634070 1.412828e-04 0.0872235823 0.43247359 22 41532659 41532745 87 - 2.828 2.853 0.085
ENSG00000100413 E015 21.5866680 1.047174e-01 0.3867409347 0.76491102 22 41533522 41533687 166 - 1.284 1.418 0.467
ENSG00000100413 E016 36.7092574 1.020509e-01 0.1664257129 0.56245388 22 41539143 41540698 1556 - 1.454 1.689 0.803
ENSG00000100413 E017 724.0445766 1.125890e-03 0.5591961998 0.85772948 22 41540699 41540795 97 - 2.858 2.851 -0.024
ENSG00000100413 E018 2.8559513 1.156839e-02 0.0013040903 0.06296605 22 41543168 41543239 72 - 0.306 0.812 2.426
ENSG00000100413 E019 1.8737485 1.015597e-02 0.0004281828 0.03283375 22 41543368 41543430 63 - 0.099 0.692 3.936
ENSG00000100413 E020 14.9262551 5.219300e-02 0.3465942851 0.73653130 22 41543752 41543990 239 - 1.125 1.265 0.496
ENSG00000100413 E021 747.2590210 9.915089e-04 0.2302618772 0.63515850 22 41543991 41544121 131 - 2.877 2.858 -0.065
ENSG00000100413 E022 550.9377109 1.258846e-03 0.0041319133 0.11505549 22 41544122 41544395 274 - 2.763 2.700 -0.211
ENSG00000100413 E023 22.2701830 1.300538e-03 0.1215010028 0.49631005 22 41544396 41544427 32 - 1.412 1.297 -0.397
ENSG00000100413 E024 43.5059905 6.755912e-04 0.6697448660 0.90407019 22 41544428 41544489 62 - 1.656 1.633 -0.076
ENSG00000100413 E025 0.5297488 2.596518e-02 0.8339686625   22 41544511 41544606 96 - 0.180 0.144 -0.389