ENSG00000100376

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000441876 ENSG00000100376 HEK293_DMSO_6hA HEK293_OSMI2_6hA FAM118A protein_coding protein_coding 15.19331 14.92939 15.44414 0.6696637 0.757609 0.048872 10.847164 8.495557 10.6926226 0.3296899 1.8353200 0.3314868 0.71875000 0.56966667 0.68370000 0.11403333 0.55016909 0.03096091 FALSE TRUE
ENST00000462361 ENSG00000100376 HEK293_DMSO_6hA HEK293_OSMI2_6hA FAM118A protein_coding retained_intron 15.19331 14.92939 15.44414 0.6696637 0.757609 0.048872 1.056825 2.560934 0.9392162 0.3059495 0.1606804 -1.4374838 0.06910417 0.17276667 0.06140000 -0.11136667 0.03096091 0.03096091   FALSE
ENST00000479180 ENSG00000100376 HEK293_DMSO_6hA HEK293_OSMI2_6hA FAM118A protein_coding processed_transcript 15.19331 14.92939 15.44414 0.6696637 0.757609 0.048872 1.003378 1.008854 1.3212375 0.1355664 0.2747774 0.3858211 0.06420833 0.06816667 0.08610000 0.01793333 0.77667645 0.03096091   FALSE
ENST00000483102 ENSG00000100376 HEK293_DMSO_6hA HEK293_OSMI2_6hA FAM118A protein_coding processed_transcript 15.19331 14.92939 15.44414 0.6696637 0.757609 0.048872 0.956792 1.644556 0.9925030 0.4732721 0.3414506 -0.7228377 0.06041250 0.10763333 0.06683333 -0.04080000 0.73061743 0.03096091   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000100376 E001 0.0000000       22 45308968 45308981 14 +      
ENSG00000100376 E002 0.0000000       22 45308982 45309040 59 +      
ENSG00000100376 E003 0.0000000       22 45309041 45309081 41 +      
ENSG00000100376 E004 0.0000000       22 45309082 45309199 118 +      
ENSG00000100376 E005 0.0000000       22 45309200 45309346 147 +      
ENSG00000100376 E006 0.0000000       22 45309347 45309650 304 +      
ENSG00000100376 E007 27.8572097 0.0104932283 0.2918302337 0.69286041 22 45309934 45310027 94 + 1.507 1.421 -0.295
ENSG00000100376 E008 39.4197317 0.0180382544 0.6009570306 0.87585858 22 45310028 45310123 96 + 1.635 1.586 -0.167
ENSG00000100376 E009 27.1574922 0.0268091651 0.6565074174 0.89936046 22 45310124 45310136 13 + 1.481 1.428 -0.182
ENSG00000100376 E010 34.2704179 0.0067624045 0.5589737158 0.85764549 22 45310137 45310183 47 + 1.574 1.531 -0.147
ENSG00000100376 E011 0.7020799 0.5887215898 0.5723779491   22 45318420 45318479 60 + 0.306 0.120 -1.688
ENSG00000100376 E012 0.7020799 0.5887215898 0.5723779491   22 45318480 45318512 33 + 0.306 0.120 -1.688
ENSG00000100376 E013 0.6378259 0.0293347538 0.3142741935   22 45318513 45318640 128 + 0.291 0.120 -1.589
ENSG00000100376 E014 0.3485388 0.0301350421 1.0000000000   22 45318791 45318960 170 + 0.120 0.120 -0.005
ENSG00000100376 E015 0.8095941 0.1487885873 0.6731217859   22 45321602 45321793 192 + 0.292 0.213 -0.592
ENSG00000100376 E016 2.2597336 0.0523202963 0.6390485277 0.89189478 22 45322042 45322215 174 + 0.462 0.549 0.421
ENSG00000100376 E017 41.8582213 0.0063622673 0.9083746223 0.97813771 22 45322371 45322426 56 + 1.636 1.629 -0.024
ENSG00000100376 E018 1.3389608 0.0145112346 0.3235154875   22 45323172 45323174 3 + 0.462 0.290 -0.997
ENSG00000100376 E019 118.1460714 0.0002493605 0.0002105150 0.02107809 22 45323175 45323427 253 + 2.130 2.014 -0.388
ENSG00000100376 E020 130.2265264 0.0002853446 0.0001922718 0.01998818 22 45327842 45328063 222 + 2.166 2.055 -0.374
ENSG00000100376 E021 0.0000000       22 45328064 45328241 178 +      
ENSG00000100376 E022 15.2520442 0.0027597823 0.6391860471 0.89194937 22 45328392 45329147 756 + 1.176 1.218 0.149
ENSG00000100376 E023 3.6081940 0.0064929980 0.3039769187 0.70299515 22 45329148 45329384 237 + 0.736 0.585 -0.640
ENSG00000100376 E024 0.7104867 0.1104801643 0.0519623554   22 45329385 45329412 28 + 0.000 0.357 10.306
ENSG00000100376 E025 0.0000000       22 45329635 45329643 9 +      
ENSG00000100376 E026 0.3312313 0.0298659200 1.0000000000   22 45329644 45329933 290 + 0.120 0.119 -0.006
ENSG00000100376 E027 0.7154891 0.4391323525 0.5499615103   22 45330457 45330602 146 + 0.122 0.295 1.575
ENSG00000100376 E028 98.6484708 0.0027274746 0.2905513494 0.69188615 22 45330603 45330731 129 + 2.013 1.970 -0.141
ENSG00000100376 E029 4.1152652 0.0833279718 0.9816704028 0.99561301 22 45330732 45330756 25 + 0.697 0.682 -0.059
ENSG00000100376 E030 92.5817332 0.0009219300 0.9534052591 0.98918708 22 45332425 45332535 111 + 1.965 1.964 -0.004
ENSG00000100376 E031 126.6756250 0.0002825783 0.2423402697 0.64733949 22 45332536 45332710 175 + 2.083 2.119 0.122
ENSG00000100376 E032 17.6667776 0.0583090324 0.1933810221 0.59564301 22 45335025 45335188 164 + 1.175 1.335 0.563
ENSG00000100376 E033 15.5663219 0.0134612350 0.0031588386 0.10118848 22 45335216 45335349 134 + 1.035 1.334 1.064
ENSG00000100376 E034 78.5560572 0.0004003001 0.5235607673 0.84187641 22 45335350 45335382 33 + 1.884 1.909 0.086
ENSG00000100376 E035 94.4943036 0.0003707018 0.5677241538 0.86128228 22 45336328 45336394 67 + 1.964 1.985 0.071
ENSG00000100376 E036 62.1059218 0.0005480221 0.5243290176 0.84231707 22 45336395 45336411 17 + 1.809 1.782 -0.092
ENSG00000100376 E037 11.6714335 0.0526842829 0.4075157839 0.77862154 22 45337834 45337968 135 + 1.167 1.034 -0.479
ENSG00000100376 E038 646.7136907 0.0002468528 0.0001000518 0.01354533 22 45340386 45341955 1570 + 2.782 2.829 0.155