ENSG00000100320

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000405409 ENSG00000100320 HEK293_DMSO_6hA HEK293_OSMI2_6hA RBFOX2 protein_coding protein_coding 35.66384 28.31427 34.37765 1.903025 4.001498 0.2798519 6.346630 9.044395 6.633651 1.3713364 1.2205543 -0.4466420 0.1880333 0.3160667 0.1949000 -0.12116667 0.21527975 0.01378493 FALSE TRUE
ENST00000438146 ENSG00000100320 HEK293_DMSO_6hA HEK293_OSMI2_6hA RBFOX2 protein_coding protein_coding 35.66384 28.31427 34.37765 1.903025 4.001498 0.2798519 11.676717 9.470010 11.321750 0.2484554 1.1750651 0.2574102 0.3287750 0.3373667 0.3319667 -0.00540000 0.98349156 0.01378493 FALSE TRUE
ENST00000473487 ENSG00000100320 HEK293_DMSO_6hA HEK293_OSMI2_6hA RBFOX2 protein_coding protein_coding 35.66384 28.31427 34.37765 1.903025 4.001498 0.2798519 7.790737 4.241850 5.859454 0.3822514 0.6493534 0.4651359 0.2108125 0.1500000 0.1706667 0.02066667 0.74287534 0.01378493 FALSE FALSE
ENST00000695854 ENSG00000100320 HEK293_DMSO_6hA HEK293_OSMI2_6hA RBFOX2 protein_coding protein_coding 35.66384 28.31427 34.37765 1.903025 4.001498 0.2798519 7.730220 4.177799 8.963788 0.4624179 1.5427988 1.0995250 0.2129708 0.1473000 0.2574667 0.11016667 0.01378493 0.01378493 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000100320 E001 18.3032288 0.0085458209 0.206864960 0.61076856 22 35738736 35738757 22 - 1.207 1.370 0.571
ENSG00000100320 E002 4321.0794682 0.0031959762 0.003563775 0.10745080 22 35738758 35743601 4844 - 3.590 3.679 0.296
ENSG00000100320 E003 250.1699468 0.0057589076 0.938764226 0.98565489 22 35743602 35743932 331 - 2.374 2.422 0.160
ENSG00000100320 E004 53.0361322 0.0005161935 0.583182215 0.86817447 22 35743933 35743957 25 - 1.713 1.742 0.099
ENSG00000100320 E005 36.3984277 0.0025367383 0.833180686 0.95793107 22 35743958 35743962 5 - 1.552 1.593 0.142
ENSG00000100320 E006 45.8096852 0.0056361723 0.493199342 0.82597819 22 35743963 35743982 20 - 1.662 1.672 0.035
ENSG00000100320 E007 105.0657588 0.0032091177 0.165959650 0.56174948 22 35743983 35744077 95 - 2.025 2.018 -0.021
ENSG00000100320 E008 73.2693441 0.0004299245 0.018021543 0.22592484 22 35744078 35744086 9 - 1.886 1.845 -0.141
ENSG00000100320 E009 91.0696087 0.0052872383 0.088764050 0.43585277 22 35744087 35744124 38 - 1.973 1.943 -0.103
ENSG00000100320 E010 88.5719469 0.0020819921 0.250714498 0.65651605 22 35744125 35744147 23 - 1.941 1.947 0.021
ENSG00000100320 E011 94.4906327 0.0023967081 0.253145760 0.65892067 22 35744148 35744163 16 - 1.970 1.976 0.023
ENSG00000100320 E012 130.9958939 0.0002435042 0.115573852 0.48552250 22 35744164 35744232 69 - 2.111 2.118 0.025
ENSG00000100320 E013 88.8667257 0.0003385005 0.126709594 0.50532563 22 35744233 35744249 17 - 1.950 1.949 -0.004
ENSG00000100320 E014 109.8040929 0.0012647796 0.014173214 0.20389175 22 35745923 35745995 73 - 2.059 2.022 -0.122
ENSG00000100320 E015 121.2695521 0.0068133393 0.245921430 0.65154014 22 35746473 35746561 89 - 2.092 2.082 -0.030
ENSG00000100320 E016 36.2879498 0.1357856426 0.022371360 0.24730137 22 35746562 35750183 3622 - 1.319 1.743 1.453
ENSG00000100320 E017 1.5357477 0.2016964975 0.720164004   22 35750184 35750260 77 - 0.338 0.444 0.595
ENSG00000100320 E018 1.1035347 0.9203141546 0.532075311   22 35750426 35750457 32 - 0.112 0.482 2.783
ENSG00000100320 E019 0.9244374 0.0565542299 0.369528247   22 35752613 35752655 43 - 0.194 0.384 1.340
ENSG00000100320 E020 88.8940105 0.0050228042 0.056973241 0.36373011 22 35756105 35756144 40 - 1.975 1.931 -0.148
ENSG00000100320 E021 161.4499150 0.0054230627 0.057073761 0.36396746 22 35759888 35760009 122 - 2.226 2.192 -0.114
ENSG00000100320 E022 90.0716542 0.0058971631 0.164689647 0.56017560 22 35760010 35760020 11 - 1.968 1.947 -0.069
ENSG00000100320 E023 43.5164071 0.0095524958 0.611431840 0.88059725 22 35760021 35760032 12 - 1.645 1.660 0.051
ENSG00000100320 E024 142.3843955 0.0007897263 0.026273154 0.26343365 22 35761202 35761294 93 - 2.162 2.147 -0.051
ENSG00000100320 E025 110.4728751 0.0025971810 0.181311111 0.58109397 22 35761415 35761468 54 - 2.043 2.043 0.001
ENSG00000100320 E026 1.7649210 0.1469827610 0.531700223 0.84592939 22 35763437 35763556 120 - 0.336 0.500 0.888
ENSG00000100320 E027 116.0409029 0.0035660063 0.114048795 0.48259020 22 35765423 35765483 61 - 2.072 2.059 -0.046
ENSG00000100320 E028 0.5080019 0.3317752450 0.699889209   22 35767368 35767441 74 - 0.200 0.132 -0.722
ENSG00000100320 E029 88.7444583 0.0040673256 0.204013454 0.60797509 22 35768257 35768267 11 - 1.955 1.948 -0.024
ENSG00000100320 E030 145.1302803 0.0019861405 0.056480561 0.36233284 22 35768268 35768341 74 - 2.170 2.156 -0.048
ENSG00000100320 E031 93.1187948 0.0034844289 0.152544360 0.54280866 22 35768342 35768349 8 - 1.980 1.968 -0.040
ENSG00000100320 E032 0.6406282 0.0193874923 0.915302339   22 35772931 35772971 41 - 0.194 0.234 0.345
ENSG00000100320 E033 1.1788711 0.0806076889 0.052563188   22 35777656 35778024 369 - 0.108 0.497 2.919
ENSG00000100320 E034 88.7049878 0.0018228969 0.121292672 0.49596031 22 35778025 35778027 3 - 1.957 1.947 -0.034
ENSG00000100320 E035 131.9591819 0.0002320513 0.007835279 0.15516783 22 35778028 35778075 48 - 2.132 2.106 -0.086
ENSG00000100320 E036 85.9719669 0.0003663363 0.025366789 0.25999813 22 35778076 35778078 3 - 1.947 1.918 -0.099
ENSG00000100320 E037 211.1802729 0.0002066735 0.001097493 0.05707014 22 35781600 35781743 144 - 2.333 2.308 -0.081
ENSG00000100320 E038 34.2935256 0.0008531507 0.157195871 0.55008596 22 35781744 35781746 3 - 1.558 1.529 -0.099
ENSG00000100320 E039 213.0463289 0.0014887747 0.009007754 0.16537402 22 35809780 35810004 225 - 2.337 2.313 -0.079
ENSG00000100320 E040 0.0000000       22 35824320 35824373 54 -      
ENSG00000100320 E041 1.2055298 0.5279260794 0.928492752   22 35836320 35836439 120 - 0.349 0.313 -0.227
ENSG00000100320 E042 372.6318589 0.0311317597 0.407963090 0.77888307 22 35838287 35838684 398 - 2.499 2.641 0.474
ENSG00000100320 E043 12.5806252 0.0619112384 0.229803236 0.63479079 22 35840192 35840587 396 - 1.006 1.229 0.803
ENSG00000100320 E044 64.5176385 0.0059613150 0.003258636 0.10285126 22 35938847 35938897 51 - 1.862 1.747 -0.389
ENSG00000100320 E045 0.0000000       22 35961463 35961534 72 -      
ENSG00000100320 E046 0.0000000       22 35961563 35961666 104 -      
ENSG00000100320 E047 77.7709964 0.0093957934 0.003679150 0.10901383 22 36028240 36028824 585 - 1.951 1.823 -0.431