ENSG00000100239

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000395744 ENSG00000100239 HEK293_DMSO_6hA HEK293_OSMI2_6hA PPP6R2 protein_coding protein_coding 44.88863 58.50836 65.75661 2.675465 2.715712 0.168466 3.750701 0.000000 7.730580 0.00000000 3.8737431 9.5962978 0.07902083 0.00000000 0.11616667 0.116166667 0.39528785 0.04509974 FALSE TRUE
ENST00000401672 ENSG00000100239 HEK293_DMSO_6hA HEK293_OSMI2_6hA PPP6R2 protein_coding protein_coding 44.88863 58.50836 65.75661 2.675465 2.715712 0.168466 4.169516 2.006674 7.961551 1.02893403 2.6108992 1.9828827 0.07146250 0.03343333 0.11970000 0.086266667 0.71469568 0.04509974 FALSE TRUE
ENST00000470046 ENSG00000100239 HEK293_DMSO_6hA HEK293_OSMI2_6hA PPP6R2 protein_coding retained_intron 44.88863 58.50836 65.75661 2.675465 2.715712 0.168466 6.480365 14.428924 9.596046 0.86940210 2.2918993 -0.5879487 0.14334167 0.24670000 0.14686667 -0.099833333 0.20897567 0.04509974 FALSE FALSE
ENST00000473283 ENSG00000100239 HEK293_DMSO_6hA HEK293_OSMI2_6hA PPP6R2 protein_coding retained_intron 44.88863 58.50836 65.75661 2.675465 2.715712 0.168466 2.554677 4.619186 3.677846 0.42447270 1.2140341 -0.3279800 0.05788750 0.07900000 0.05660000 -0.022400000 0.65857561 0.04509974   FALSE
ENST00000612753 ENSG00000100239 HEK293_DMSO_6hA HEK293_OSMI2_6hA PPP6R2 protein_coding protein_coding 44.88863 58.50836 65.75661 2.675465 2.715712 0.168466 6.813610 11.275755 7.919441 0.70585702 0.4845347 -0.5092118 0.13998333 0.19353333 0.12100000 -0.072533333 0.04509974 0.04509974 FALSE TRUE
MSTRG.22375.13 ENSG00000100239 HEK293_DMSO_6hA HEK293_OSMI2_6hA PPP6R2 protein_coding   44.88863 58.50836 65.75661 2.675465 2.715712 0.168466 8.185481 8.923290 12.810847 0.87977603 1.3541472 0.5212280 0.20212917 0.15210000 0.19393333 0.041833333 0.37790784 0.04509974 TRUE TRUE
MSTRG.22375.22 ENSG00000100239 HEK293_DMSO_6hA HEK293_OSMI2_6hA PPP6R2 protein_coding   44.88863 58.50836 65.75661 2.675465 2.715712 0.168466 3.480963 6.976998 4.694484 0.59295654 1.6877806 -0.5706362 0.08279583 0.11933333 0.07190000 -0.047433333 0.38037435 0.04509974 FALSE TRUE
MSTRG.22375.9 ENSG00000100239 HEK293_DMSO_6hA HEK293_OSMI2_6hA PPP6R2 protein_coding   44.88863 58.50836 65.75661 2.675465 2.715712 0.168466 3.107451 3.113439 3.920176 0.01588831 0.2097094 0.3314585 0.07714583 0.05340000 0.05993333 0.006533333 0.77889217 0.04509974 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000100239 E001 0.2892872 2.744240e-02 0.2517855456   22 50343304 50343320 17 + 0.196 0.000 -11.702
ENSG00000100239 E002 0.4018037 2.269565e-02 0.1156300701   22 50343321 50343322 2 + 0.268 0.000 -12.283
ENSG00000100239 E003 0.5143203 2.845130e-02 0.0578895019   22 50343323 50343326 4 + 0.330 0.000 -12.694
ENSG00000100239 E004 0.6910909 2.005699e-02 0.0281459928   22 50343327 50343329 3 + 0.385 0.000 -13.020
ENSG00000100239 E005 0.8455516 1.955334e-02 0.1428788999   22 50343330 50343330 1 + 0.385 0.131 -2.019
ENSG00000100239 E006 0.9580682 3.410302e-02 0.0918514610   22 50343331 50343331 1 + 0.432 0.131 -2.276
ENSG00000100239 E007 1.4191235 3.461414e-02 0.1135433285   22 50343332 50343334 3 + 0.514 0.231 -1.690
ENSG00000100239 E008 3.0456436 1.156744e-02 0.0141500329 0.203751874 22 50343335 50343339 5 + 0.766 0.381 -1.781
ENSG00000100239 E009 3.3126208 2.015705e-02 0.0283505681 0.273056919 22 50343340 50343341 2 + 0.785 0.440 -1.536
ENSG00000100239 E010 4.1251073 4.242319e-02 0.0077443231 0.154410304 22 50343342 50343344 3 + 0.887 0.440 -1.933
ENSG00000100239 E011 4.4626570 8.066115e-02 0.0111321055 0.182642582 22 50343345 50343345 1 + 0.923 0.440 -2.073
ENSG00000100239 E012 6.3873432 1.504954e-01 0.0172830435 0.222201556 22 50343346 50343346 1 + 1.052 0.539 -2.062
ENSG00000100239 E013 9.3561892 6.775178e-02 0.0042406523 0.116729941 22 50343347 50343355 9 + 1.190 0.719 -1.773
ENSG00000100239 E014 15.6471807 3.235731e-02 0.0002762319 0.024984646 22 50343356 50343368 13 + 1.386 0.943 -1.585
ENSG00000100239 E015 88.3013826 1.396888e-03 0.0000120809 0.003530713 22 50343369 50343550 182 + 2.022 1.856 -0.557
ENSG00000100239 E016 1.2917726 5.796669e-02 0.6518643952   22 50360134 50360195 62 + 0.386 0.313 -0.438
ENSG00000100239 E017 84.4499162 2.586424e-03 0.1271531024 0.506000477 22 50372020 50372071 52 + 1.954 1.900 -0.181
ENSG00000100239 E018 156.0531491 2.983073e-04 0.5209450821 0.840540624 22 50372072 50372150 79 + 2.195 2.191 -0.012
ENSG00000100239 E019 9.2778602 2.867944e-03 0.8084664788 0.950912381 22 50388986 50389033 48 + 0.981 1.021 0.146
ENSG00000100239 E020 19.3528566 8.424918e-03 0.6530438398 0.897776132 22 50389034 50389111 78 + 1.307 1.286 -0.073
ENSG00000100239 E021 6.3064564 3.694611e-03 0.9577920660 0.990388852 22 50391867 50392015 149 + 0.845 0.865 0.077
ENSG00000100239 E022 5.6533424 2.288199e-02 0.9237303315 0.981840845 22 50393750 50393799 50 + 0.793 0.821 0.111
ENSG00000100239 E023 411.4879978 1.112046e-04 0.0084606106 0.160400866 22 50393893 50394135 243 + 2.627 2.596 -0.105
ENSG00000100239 E024 228.1546956 1.904142e-04 0.0190475425 0.231014362 22 50406689 50406734 46 + 2.378 2.337 -0.137
ENSG00000100239 E025 369.5757951 2.020269e-04 0.3799477506 0.760120268 22 50406735 50406875 141 + 2.569 2.567 -0.008
ENSG00000100239 E026 339.4034455 2.232160e-03 0.6931981491 0.912880729 22 50414552 50414689 138 + 2.518 2.544 0.086
ENSG00000100239 E027 258.3713026 9.609512e-04 0.2927554874 0.693685748 22 50416092 50416157 66 + 2.390 2.433 0.145
ENSG00000100239 E028 321.7371653 1.623576e-03 0.3730196849 0.755268920 22 50418867 50418979 113 + 2.512 2.504 -0.027
ENSG00000100239 E029 7.3155794 1.137404e-01 0.1440573624 0.530849538 22 50418980 50418989 10 + 0.766 1.024 0.986
ENSG00000100239 E030 14.7249202 2.197427e-03 0.0203069339 0.237490686 22 50419346 50419348 3 + 1.064 1.285 0.789
ENSG00000100239 E031 350.0683858 1.225419e-04 0.0959609079 0.449988826 22 50419349 50419441 93 + 2.552 2.535 -0.056
ENSG00000100239 E032 222.1749882 1.580925e-04 0.0631218901 0.380110302 22 50419442 50419462 21 + 2.362 2.332 -0.099
ENSG00000100239 E033 360.7957103 1.269911e-04 0.3759441057 0.757262819 22 50422254 50422380 127 + 2.557 2.556 -0.005
ENSG00000100239 E034 357.5629621 1.289701e-04 0.1127193867 0.480404744 22 50423462 50423604 143 + 2.559 2.544 -0.050
ENSG00000100239 E035 176.4324835 1.850863e-04 0.2384271421 0.643697735 22 50423605 50423614 10 + 2.253 2.236 -0.055
ENSG00000100239 E036 499.9931136 1.249610e-04 0.0102813113 0.175671191 22 50431173 50431382 210 + 2.709 2.682 -0.087
ENSG00000100239 E037 308.3955635 2.602567e-04 0.0190308363 0.230930057 22 50432265 50432329 65 + 2.503 2.469 -0.114
ENSG00000100239 E038 449.1237724 9.564471e-05 0.0838996319 0.425582347 22 50434966 50435081 116 + 2.659 2.644 -0.047
ENSG00000100239 E039 378.5089035 1.160204e-04 0.9808336267 0.995394307 22 50436367 50436452 86 + 2.571 2.586 0.050
ENSG00000100239 E040 72.8107899 9.833423e-02 0.0177913640 0.225037526 22 50436701 50436987 287 + 1.679 2.008 1.109
ENSG00000100239 E041 247.4046111 1.364150e-04 0.9806514680 0.995312274 22 50436988 50437068 81 + 2.385 2.400 0.051
ENSG00000100239 E042 491.4556056 1.033273e-04 0.7430193160 0.930333506 22 50437506 50437603 98 + 2.684 2.694 0.033
ENSG00000100239 E043 435.5590382 1.042195e-04 0.5696564003 0.862221884 22 50437843 50437900 58 + 2.625 2.649 0.083
ENSG00000100239 E044 518.7923576 2.191282e-04 0.5338986600 0.847074613 22 50438174 50438298 125 + 2.699 2.726 0.087
ENSG00000100239 E045 568.4915727 1.471415e-04 0.7953133167 0.946564226 22 50438599 50438762 164 + 2.747 2.758 0.039
ENSG00000100239 E046 25.7116930 7.415918e-03 0.3754773738 0.756840144 22 50439698 50439700 3 + 1.376 1.460 0.291
ENSG00000100239 E047 386.4638760 1.227998e-04 0.2470727960 0.652496503 22 50439701 50439752 52 + 2.589 2.583 -0.020
ENSG00000100239 E048 418.2159929 1.127598e-04 0.3621131301 0.748353906 22 50439753 50439857 105 + 2.622 2.621 -0.003
ENSG00000100239 E049 24.3879588 2.662314e-02 0.1009637171 0.459090062 22 50439858 50439960 103 + 1.302 1.481 0.621
ENSG00000100239 E050 368.3995023 1.359834e-04 0.0959145631 0.449923942 22 50439961 50440049 89 + 2.574 2.558 -0.054
ENSG00000100239 E051 15.2916126 4.249277e-02 0.0467969721 0.335333743 22 50440801 50440821 21 + 1.063 1.322 0.923
ENSG00000100239 E052 374.1891193 4.204242e-04 0.0115415844 0.185701953 22 50440822 50440955 134 + 2.591 2.555 -0.121
ENSG00000100239 E053 276.8003396 7.025031e-03 0.2794519678 0.682873581 22 50440956 50441026 71 + 2.457 2.429 -0.092
ENSG00000100239 E054 38.2879969 1.075664e-01 0.0839807619 0.425783004 22 50441027 50441074 48 + 1.450 1.706 0.877
ENSG00000100239 E055 364.1029378 5.933786e-02 0.0102158511 0.175226008 22 50443087 50443865 779 + 2.406 2.685 0.930
ENSG00000100239 E056 660.2064754 6.991392e-04 0.9015934185 0.976693840 22 50443866 50444117 252 + 2.813 2.827 0.046
ENSG00000100239 E057 183.8012094 2.145121e-04 0.5153289629 0.837841513 22 50444199 50444202 4 + 2.248 2.280 0.108
ENSG00000100239 E058 292.8473536 1.305943e-04 0.5986154783 0.875050273 22 50444203 50444312 110 + 2.452 2.478 0.086
ENSG00000100239 E059 201.8939691 3.447669e-03 0.0000191152 0.004731978 22 50444313 50444649 337 + 2.211 2.387 0.589
ENSG00000100239 E060 228.0290278 1.649689e-02 0.0002881750 0.025752843 22 50444650 50445090 441 + 2.223 2.470 0.825