ENSG00000099917

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000263205 ENSG00000099917 HEK293_DMSO_6hA HEK293_OSMI2_6hA MED15 protein_coding protein_coding 44.8678 45.54315 72.798 3.562664 9.543556 0.6765463 7.728045 6.863235 14.400773 0.3164328 2.6945744 1.0680866 0.1707292 0.1515667 0.1945667 0.04300000 0.29140491 0.03167514 FALSE TRUE
ENST00000292733 ENSG00000099917 HEK293_DMSO_6hA HEK293_OSMI2_6hA MED15 protein_coding protein_coding 44.8678 45.54315 72.798 3.562664 9.543556 0.6765463 16.783505 14.303918 28.156766 1.1913502 6.5370292 0.9765753 0.3782292 0.3138000 0.3751000 0.06130000 0.69338799 0.03167514 FALSE TRUE
ENST00000473244 ENSG00000099917 HEK293_DMSO_6hA HEK293_OSMI2_6hA MED15 protein_coding retained_intron 44.8678 45.54315 72.798 3.562664 9.543556 0.6765463 5.405974 10.269058 9.060568 0.6022203 0.1608248 -0.1804433 0.1063125 0.2262667 0.1299333 -0.09633333 0.03167514 0.03167514 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000099917 E001 0.0000000       22 20495913 20495923 11 +      
ENSG00000099917 E002 1.6207645 0.0271102203 0.1923307182   22 20495924 20495989 66 + 0.485 0.252 -1.384
ENSG00000099917 E003 10.6209579 0.0100795370 0.8716344378 0.96863274 22 20495990 20496036 47 + 1.060 1.051 -0.036
ENSG00000099917 E004 19.5277475 0.0418973899 0.0362786108 0.30150420 22 20498667 20498791 125 + 1.175 1.437 0.914
ENSG00000099917 E005 13.1241185 0.0267477645 0.0620834690 0.37718752 22 20499241 20499366 126 + 1.038 1.262 0.802
ENSG00000099917 E006 15.8236605 0.0016097331 0.0560314221 0.36108976 22 20500741 20500836 96 + 1.139 1.307 0.597
ENSG00000099917 E007 8.4758900 0.0277492016 0.2052365523 0.60892258 22 20500837 20500929 93 + 0.875 1.051 0.658
ENSG00000099917 E008 2.6884351 0.0075921467 0.5474584526 0.85298327 22 20507291 20507394 104 + 0.518 0.618 0.456
ENSG00000099917 E009 2.2042903 0.0108326421 0.1258661357 0.50384461 22 20507541 20507581 41 + 0.358 0.618 1.302
ENSG00000099917 E010 1.9638286 0.0112025853 0.2069280319 0.61080668 22 20507582 20507582 1 + 0.357 0.575 1.112
ENSG00000099917 E011 2.5994544 0.0100953436 0.0754152993 0.40792268 22 20507583 20507584 2 + 0.403 0.694 1.365
ENSG00000099917 E012 5.5183106 0.2598281365 0.3593884301 0.74648588 22 20507585 20507593 9 + 0.680 0.938 1.017
ENSG00000099917 E013 5.5261152 0.2664585153 0.3666652364 0.75135952 22 20507594 20507594 1 + 0.680 0.939 1.020
ENSG00000099917 E014 12.0003361 0.0377298599 0.6307554808 0.88836853 22 20507595 20507601 7 + 1.116 1.084 -0.117
ENSG00000099917 E015 28.2962928 0.0010334622 0.9941693533 0.99851389 22 20507602 20507609 8 + 1.459 1.468 0.030
ENSG00000099917 E016 29.0835770 0.0010159511 0.8770955484 0.97047071 22 20507610 20507611 2 + 1.467 1.485 0.062
ENSG00000099917 E017 33.9036809 0.0008805178 0.4093184134 0.77993521 22 20507612 20507617 6 + 1.513 1.571 0.197
ENSG00000099917 E018 79.6512910 0.0111513782 0.2748181937 0.67852948 22 20507618 20507640 23 + 1.925 1.871 -0.180
ENSG00000099917 E019 206.2129622 0.0062740604 0.0288309715 0.27493142 22 20507641 20507735 95 + 2.346 2.259 -0.291
ENSG00000099917 E020 164.8728579 0.0002524533 0.0120370950 0.18961518 22 20507736 20507746 11 + 2.243 2.179 -0.212
ENSG00000099917 E021 0.3485388 0.0299631355 0.7666778723   22 20508048 20508056 9 + 0.099 0.144 0.623
ENSG00000099917 E022 1.1966508 0.1913418638 0.9143275537   22 20508057 20508444 388 + 0.315 0.337 0.137
ENSG00000099917 E023 20.4360352 0.0121076775 0.0710268837 0.39768191 22 20518878 20518995 118 + 1.382 1.224 -0.551
ENSG00000099917 E024 0.1717682 0.0324976160 0.3313185835   22 20523643 20523855 213 + 0.000 0.144 11.802
ENSG00000099917 E025 0.4979971 0.0275992574 0.0388707437   22 20524275 20524286 12 + 0.000 0.339 13.459
ENSG00000099917 E026 0.6697652 0.1056563606 0.0205550632   22 20524287 20524366 80 + 0.000 0.411 13.231
ENSG00000099917 E027 312.4551209 0.0028875175 0.0483594405 0.33994801 22 20537117 20537204 88 + 2.511 2.461 -0.169
ENSG00000099917 E028 3.8536580 0.0221114344 0.8301560011 0.95690313 22 20537205 20537215 11 + 0.686 0.657 -0.120
ENSG00000099917 E029 0.1767706 0.0411456823 0.7004737130   22 20550987 20551006 20 + 0.099 0.000 -11.723
ENSG00000099917 E030 0.1767706 0.0411456823 0.7004737130   22 20551007 20551166 160 + 0.099 0.000 -11.723
ENSG00000099917 E031 0.0000000       22 20551167 20551240 74 +      
ENSG00000099917 E032 0.0000000       22 20551241 20551289 49 +      
ENSG00000099917 E033 0.0000000       22 20551290 20551312 23 +      
ENSG00000099917 E034 0.0000000       22 20551313 20551347 35 +      
ENSG00000099917 E035 0.3356707 0.0395719472 0.7624259876   22 20551407 20551435 29 + 0.099 0.144 0.620
ENSG00000099917 E036 245.4700232 0.0024774715 0.0012707695 0.06213571 22 20551436 20551487 52 + 2.423 2.329 -0.315
ENSG00000099917 E037 4.0152783 0.0071184815 0.0699837089 0.39555667 22 20551488 20551748 261 + 0.580 0.839 1.077
ENSG00000099917 E038 4.6715688 0.0049252593 0.0297377781 0.27848801 22 20552539 20552709 171 + 0.581 0.886 1.252
ENSG00000099917 E039 1.1530695 0.0140914360 0.8727598876   22 20553097 20553144 48 + 0.306 0.339 0.208
ENSG00000099917 E040 193.4544418 0.0001935349 0.0078519024 0.15533830 22 20553145 20553174 30 + 2.308 2.247 -0.205
ENSG00000099917 E041 3.2741611 0.0065573280 0.0748543785 0.40664998 22 20554239 20554935 697 + 0.483 0.758 1.211
ENSG00000099917 E042 227.4367132 0.0002832847 0.0144295323 0.20520862 22 20554936 20554995 60 + 2.372 2.321 -0.171
ENSG00000099917 E043 229.2135499 0.0001759085 0.0511343139 0.34716659 22 20554996 20555076 81 + 2.371 2.333 -0.128
ENSG00000099917 E044 213.6736683 0.0002449553 0.2374264965 0.64256265 22 20555077 20555148 72 + 2.338 2.317 -0.072
ENSG00000099917 E045 267.9675023 0.0024862501 0.0616057734 0.37586289 22 20564450 20564688 239 + 2.446 2.398 -0.160
ENSG00000099917 E046 0.1795728 0.0329454994 0.3310268071   22 20566465 20566466 2 + 0.000 0.144 11.796
ENSG00000099917 E047 332.4108941 0.0005395386 0.0339216502 0.29375831 22 20566467 20566817 351 + 2.537 2.498 -0.131
ENSG00000099917 E048 229.1560625 0.0001751472 0.0754740205 0.40798318 22 20568521 20568631 111 + 2.372 2.338 -0.116
ENSG00000099917 E049 82.2288967 0.0852168150 0.0890524328 0.43652683 22 20573678 20575112 1435 + 1.802 2.031 0.768
ENSG00000099917 E050 91.4623966 0.0020168858 0.8518029670 0.96331937 22 20575113 20575232 120 + 1.955 1.971 0.054
ENSG00000099917 E051 69.5472143 0.0603912059 0.0073170097 0.15050338 22 20581901 20582093 193 + 1.670 2.002 1.119
ENSG00000099917 E052 111.4850258 0.0428387604 0.0021252687 0.08230338 22 20582094 20582610 517 + 1.873 2.205 1.111
ENSG00000099917 E053 145.0174101 0.0071637169 0.9254239774 0.98227119 22 20582611 20582658 48 + 2.150 2.175 0.083
ENSG00000099917 E054 141.1191005 0.0058855592 0.7176914543 0.92135058 22 20582659 20582697 39 + 2.131 2.170 0.130
ENSG00000099917 E055 165.7222107 0.0024440996 0.7241221395 0.92353885 22 20582698 20582747 50 + 2.203 2.232 0.097
ENSG00000099917 E056 11.0277600 0.0606968338 0.5463451365 0.85248361 22 20582748 20582839 92 + 1.018 1.125 0.387
ENSG00000099917 E057 305.5988156 0.0007177692 0.7342579313 0.92722425 22 20582840 20582929 90 + 2.475 2.493 0.061
ENSG00000099917 E058 276.1679198 0.0001634980 0.1871826998 0.58823929 22 20582930 20582967 38 + 2.422 2.459 0.122
ENSG00000099917 E059 5.5425293 0.1943758237 0.1910846137 0.59297815 22 20582968 20583112 145 + 0.671 0.946 1.085
ENSG00000099917 E060 461.0031315 0.0008919030 0.6783661395 0.90744619 22 20583113 20583247 135 + 2.652 2.672 0.064
ENSG00000099917 E061 225.9697987 0.0013695013 0.9211852922 0.98111379 22 20583330 20583333 4 + 2.346 2.359 0.043
ENSG00000099917 E062 238.3494288 0.0006463465 0.9791242984 0.99497580 22 20583334 20583337 4 + 2.370 2.380 0.034
ENSG00000099917 E063 380.1017064 0.0001116243 0.2632248986 0.66821073 22 20583338 20583393 56 + 2.582 2.570 -0.042
ENSG00000099917 E064 49.9609392 0.0440384916 0.0148300378 0.20747743 22 20583394 20584358 965 + 1.554 1.842 0.977
ENSG00000099917 E065 384.2875880 0.0001483217 0.0987345639 0.45486691 22 20584359 20584425 67 + 2.591 2.568 -0.076
ENSG00000099917 E066 48.2312276 0.1311296871 0.0878112583 0.43392275 22 20584426 20584854 429 + 1.555 1.818 0.890
ENSG00000099917 E067 444.9749552 0.0002454345 0.7646737075 0.93758234 22 20584855 20584945 91 + 2.645 2.648 0.009
ENSG00000099917 E068 448.2523784 0.0006862153 0.5713711071 0.86276298 22 20584946 20585015 70 + 2.641 2.661 0.066
ENSG00000099917 E069 41.3284361 0.0007484141 0.0001144934 0.01453128 22 20585016 20585100 85 + 1.517 1.734 0.738
ENSG00000099917 E070 679.1959599 0.0009911127 0.6262597321 0.88656507 22 20585101 20585267 167 + 2.818 2.839 0.069
ENSG00000099917 E071 54.9280147 0.0973285200 0.0342080585 0.29473376 22 20585268 20585727 460 + 1.585 1.891 1.035
ENSG00000099917 E072 536.6131339 0.0007449400 0.7624480741 0.93666785 22 20585728 20585826 99 + 2.716 2.734 0.059
ENSG00000099917 E073 2017.3004153 0.0013538576 0.9935102129 0.99839238 22 20586568 20587632 1065 + 3.292 3.309 0.055