ENSG00000093183

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264454 ENSG00000093183 HEK293_DMSO_6hA HEK293_OSMI2_6hA SEC22C protein_coding protein_coding 28.78445 31.03462 21.8895 1.147675 1.065337 -0.5034455 7.2732181 2.7941788 5.4398820 1.63954655 0.8110754 0.9586467 0.24748333 0.093266667 0.25276667 0.159500000 0.72700176 0.01606031 FALSE TRUE
ENST00000273156 ENSG00000093183 HEK293_DMSO_6hA HEK293_OSMI2_6hA SEC22C protein_coding protein_coding 28.78445 31.03462 21.8895 1.147675 1.065337 -0.5034455 11.4007598 13.7340660 9.7864781 1.23046232 0.5744469 -0.4884738 0.40353750 0.441433333 0.44790000 0.006466667 0.98185826 0.01606031 FALSE TRUE
ENST00000417572 ENSG00000093183 HEK293_DMSO_6hA HEK293_OSMI2_6hA SEC22C protein_coding protein_coding 28.78445 31.03462 21.8895 1.147675 1.065337 -0.5034455 0.8078789 0.1575218 1.3171655 0.08763671 0.2627213 2.9859272 0.02873333 0.005233333 0.06026667 0.055033333 0.01606031 0.01606031 FALSE TRUE
ENST00000451653 ENSG00000093183 HEK293_DMSO_6hA HEK293_OSMI2_6hA SEC22C protein_coding protein_coding 28.78445 31.03462 21.8895 1.147675 1.065337 -0.5034455 2.8893640 7.1975965 0.8882321 2.03579582 0.8882321 -3.0043581 0.09752917 0.227600000 0.03800000 -0.189600000 0.27304111 0.01606031 FALSE TRUE
MSTRG.22811.12 ENSG00000093183 HEK293_DMSO_6hA HEK293_OSMI2_6hA SEC22C protein_coding   28.78445 31.03462 21.8895 1.147675 1.065337 -0.5034455 2.0380171 1.7228293 0.5288839 0.37382155 0.3077346 -1.6850832 0.06959583 0.056100000 0.02536667 -0.030733333 0.64420064 0.01606031 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000093183 E001 1.4385193 0.0115823090 7.324360e-01   3 42547969 42547970 2 - 0.338 0.404 0.386
ENSG00000093183 E002 2.9610778 0.0093818443 8.539684e-01 0.963861687 3 42547971 42547983 13 - 0.573 0.610 0.166
ENSG00000093183 E003 27.3100433 0.0010084173 7.880713e-01 0.944596020 3 42547984 42548003 20 - 1.417 1.445 0.098
ENSG00000093183 E004 80.0508349 0.0086963758 6.684369e-01 0.903577925 3 42548004 42548141 138 - 1.902 1.887 -0.050
ENSG00000093183 E005 102.9591277 0.0011661812 8.059040e-02 0.418762014 3 42548142 42548182 41 - 2.032 1.975 -0.189
ENSG00000093183 E006 85.7603384 0.0004364279 3.814589e-01 0.761167728 3 42548183 42548189 7 - 1.932 1.908 -0.080
ENSG00000093183 E007 88.5903702 0.0017349616 1.239580e-01 0.500415883 3 42548190 42548203 14 - 1.967 1.912 -0.184
ENSG00000093183 E008 156.1615893 0.0007174972 3.997468e-01 0.773191843 3 42548204 42548310 107 - 2.186 2.169 -0.054
ENSG00000093183 E009 67.7691627 0.0005071359 5.717388e-01 0.862945118 3 42548311 42548313 3 - 1.794 1.830 0.120
ENSG00000093183 E010 141.7341271 0.0004628264 7.978586e-01 0.947595048 3 42548314 42548377 64 - 2.119 2.137 0.061
ENSG00000093183 E011 314.4712041 0.0002972848 1.096773e-01 0.475138146 3 42548378 42548657 280 - 2.450 2.493 0.146
ENSG00000093183 E012 389.6322128 0.0051437407 1.174103e-01 0.488918757 3 42548658 42549841 1184 - 2.534 2.596 0.207
ENSG00000093183 E013 877.2586538 0.0093546671 2.148747e-01 0.619467387 3 42549842 42553253 3412 - 2.893 2.946 0.178
ENSG00000093183 E014 159.4400475 0.0004034316 1.617274e-01 0.556497809 3 42553254 42553406 153 - 2.200 2.169 -0.104
ENSG00000093183 E015 107.2973074 0.0028003942 1.166815e-01 0.487549843 3 42553407 42553448 42 - 2.046 1.989 -0.190
ENSG00000093183 E016 123.8079427 0.0065647159 9.885974e-01 0.997208029 3 42555930 42555930 1 - 2.069 2.082 0.042
ENSG00000093183 E017 218.6489549 0.0044581392 8.747359e-01 0.969761371 3 42555931 42555995 65 - 2.319 2.322 0.008
ENSG00000093183 E018 270.2855151 0.0027664473 7.980449e-01 0.947645143 3 42557578 42557696 119 - 2.414 2.411 -0.008
ENSG00000093183 E019 0.3089214 0.3993342454 4.650590e-01   3 42561115 42561116 2 - 0.000 0.177 10.636
ENSG00000093183 E020 225.8904441 0.0023229184 9.787487e-01 0.994845568 3 42561117 42561214 98 - 2.330 2.337 0.026
ENSG00000093183 E021 208.8905688 0.0002933385 7.653554e-01 0.937753386 3 42561215 42561296 82 - 2.297 2.300 0.009
ENSG00000093183 E022 125.5023168 0.0030197994 7.076816e-01 0.917958384 3 42563523 42563523 1 - 2.066 2.090 0.082
ENSG00000093183 E023 132.4122571 0.0024145183 8.833245e-01 0.971976589 3 42563524 42563544 21 - 2.094 2.109 0.052
ENSG00000093183 E024 115.9515835 0.0023578024 8.912733e-01 0.973974376 3 42563545 42563546 2 - 2.043 2.047 0.013
ENSG00000093183 E025 173.8870520 0.0041072967 3.329081e-01 0.726854238 3 42563547 42563608 62 - 2.243 2.211 -0.107
ENSG00000093183 E026 164.8777705 0.0047221380 1.055547e-01 0.467696051 3 42563609 42563686 78 - 2.240 2.175 -0.216
ENSG00000093183 E027 16.6076233 0.0025031719 9.792293e-02 0.453392639 3 42563765 42563810 46 - 1.120 1.277 0.558
ENSG00000093183 E028 16.6291582 0.0016688227 4.350738e-02 0.324996340 3 42563811 42563844 34 - 1.093 1.283 0.674
ENSG00000093183 E029 19.1416342 0.0015412425 1.262197e-02 0.193841693 3 42563845 42563880 36 - 1.132 1.352 0.776
ENSG00000093183 E030 14.0429401 0.0018207729 3.232392e-03 0.102340208 3 42563881 42563888 8 - 0.947 1.247 1.084
ENSG00000093183 E031 13.9620025 0.0018478243 3.216293e-03 0.102179573 3 42563889 42563926 38 - 0.947 1.247 1.084
ENSG00000093183 E032 14.8956943 0.0016610739 1.137797e-01 0.482050751 3 42563927 42563980 54 - 1.079 1.234 0.553
ENSG00000093183 E033 21.5835758 0.0166274605 4.301446e-01 0.791942477 3 42563981 42564415 435 - 1.284 1.361 0.269
ENSG00000093183 E034 5.1021824 0.0802287778 6.059886e-01 0.878077032 3 42565776 42565883 108 - 0.701 0.802 0.407
ENSG00000093183 E035 3.8281319 0.0397356104 4.464349e-01 0.801597377 3 42566744 42566836 93 - 0.577 0.706 0.556
ENSG00000093183 E036 250.8801153 0.0033099185 5.329799e-03 0.130737583 3 42568865 42569073 209 - 2.437 2.345 -0.305
ENSG00000093183 E037 0.8998008 0.0187870165 5.909214e-01   3 42573400 42573547 148 - 0.337 0.247 -0.614
ENSG00000093183 E038 2.2849941 0.0084618992 8.093157e-01 0.951297029 3 42579477 42579593 117 - 0.472 0.519 0.232
ENSG00000093183 E039 1.1056475 0.0263526431 8.342781e-01   3 42580443 42580505 63 - 0.338 0.306 -0.206
ENSG00000093183 E040 0.2920894 0.0280037257 7.424135e-01   3 42581312 42581365 54 - 0.143 0.099 -0.612
ENSG00000093183 E041 117.1777953 0.0105436654 3.613021e-02 0.301047606 3 42581846 42582028 183 - 2.121 2.007 -0.382
ENSG00000093183 E042 6.5953762 0.0848635736 9.512160e-01 0.988641502 3 42582193 42584390 2198 - 0.890 0.871 -0.073
ENSG00000093183 E043 0.1767706 0.0328853328 3.151252e-01   3 42587411 42587562 152 - 0.144 0.000 -11.064
ENSG00000093183 E044 8.9893195 0.0141998336 2.280440e-03 0.085071912 3 42600411 42600524 114 - 1.168 0.822 -1.282
ENSG00000093183 E045 5.9811362 0.0059010517 2.108151e-06 0.001000973 3 42600960 42601080 121 - 1.094 0.484 -2.478