ENSG00000093167

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000421276 ENSG00000093167 HEK293_DMSO_6hA HEK293_OSMI2_6hA LRRFIP2 protein_coding protein_coding 31.66559 18.26802 26.6451 3.128583 5.049836 0.5443018 12.5553527 8.5712143 12.0324218 1.78255579 2.36182781 0.48887184 0.40774167 0.46423333 0.45400000 -0.01023333 0.95370654 0.02955274 FALSE TRUE
ENST00000490597 ENSG00000093167 HEK293_DMSO_6hA HEK293_OSMI2_6hA LRRFIP2 protein_coding processed_transcript 31.66559 18.26802 26.6451 3.128583 5.049836 0.5443018 1.9050218 0.6174467 0.6352677 0.17103788 0.11804503 0.04040495 0.05517500 0.03376667 0.02406667 -0.00970000 0.75217760 0.02955274   FALSE
ENST00000496479 ENSG00000093167 HEK293_DMSO_6hA HEK293_OSMI2_6hA LRRFIP2 protein_coding retained_intron 31.66559 18.26802 26.6451 3.128583 5.049836 0.5443018 0.6537471 1.3449612 0.3313760 0.39521860 0.07095194 -1.98881792 0.02306667 0.07116667 0.01493333 -0.05623333 0.02955274 0.02955274 FALSE TRUE
ENST00000496825 ENSG00000093167 HEK293_DMSO_6hA HEK293_OSMI2_6hA LRRFIP2 protein_coding processed_transcript 31.66559 18.26802 26.6451 3.128583 5.049836 0.5443018 2.4536988 1.2140376 2.5870360 0.09485609 0.79767994 1.08521817 0.07953333 0.07070000 0.09466667 0.02396667 0.73738356 0.02955274   FALSE
MSTRG.22700.13 ENSG00000093167 HEK293_DMSO_6hA HEK293_OSMI2_6hA LRRFIP2 protein_coding   31.66559 18.26802 26.6451 3.128583 5.049836 0.5443018 3.4342601 1.7062567 3.1109408 0.19048120 0.78773973 0.86271566 0.10820000 0.09923333 0.11320000 0.01396667 0.78818219 0.02955274 FALSE TRUE
MSTRG.22700.25 ENSG00000093167 HEK293_DMSO_6hA HEK293_OSMI2_6hA LRRFIP2 protein_coding   31.66559 18.26802 26.6451 3.128583 5.049836 0.5443018 1.8888938 0.2479224 0.5329175 0.08979290 0.09905292 1.07379563 0.05244167 0.01283333 0.02003333 0.00720000 0.73875346 0.02955274   FALSE
MSTRG.22700.31 ENSG00000093167 HEK293_DMSO_6hA HEK293_OSMI2_6hA LRRFIP2 protein_coding   31.66559 18.26802 26.6451 3.128583 5.049836 0.5443018 2.1311359 1.4392845 3.0512030 0.30981549 0.81179446 1.07875783 0.07362083 0.08630000 0.11033333 0.02403333 0.74920452 0.02955274   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000093167 E001 0.5607039 0.0192414349 4.309214e-01   3 37052626 37052655 30 - 0.265 0.133 -1.227
ENSG00000093167 E002 10.2876013 0.0777141737 5.442116e-01 8.517502e-01 3 37052656 37053003 348 - 1.085 1.035 -0.181
ENSG00000093167 E003 209.0623090 0.0039249476 5.767421e-01 8.653063e-01 3 37053004 37053605 602 - 2.305 2.340 0.114
ENSG00000093167 E004 93.4331397 0.0042689502 5.880299e-01 8.704160e-01 3 37053606 37053686 81 - 1.957 1.998 0.136
ENSG00000093167 E005 59.2356212 0.0010337041 7.950982e-02 4.166415e-01 3 37053687 37053720 34 - 1.740 1.832 0.311
ENSG00000093167 E006 64.4160140 0.0029796094 3.011609e-02 2.800165e-01 3 37053721 37053749 29 - 1.761 1.881 0.405
ENSG00000093167 E007 201.5670143 0.0001781554 2.471444e-01 6.525623e-01 3 37053750 37053961 212 - 2.294 2.332 0.127
ENSG00000093167 E008 171.8313086 0.0002234034 8.615478e-01 9.662230e-01 3 37054411 37054515 105 - 2.239 2.244 0.018
ENSG00000093167 E009 156.4883531 0.0002353728 4.201199e-01 7.861601e-01 3 37055086 37055165 80 - 2.207 2.195 -0.041
ENSG00000093167 E010 145.7043430 0.0002251260 8.807289e-01 9.713975e-01 3 37058790 37058858 69 - 2.162 2.176 0.048
ENSG00000093167 E011 124.9059537 0.0002533792 1.347895e-01 5.175440e-01 3 37058859 37058910 52 - 2.075 2.132 0.189
ENSG00000093167 E012 124.5096408 0.0002958669 1.245994e-01 5.015449e-01 3 37063742 37063791 50 - 2.074 2.132 0.193
ENSG00000093167 E013 12.8545925 0.0023994882 1.863795e-07 1.651591e-04 3 37063792 37065334 1543 - 0.820 1.338 1.891
ENSG00000093167 E014 148.7483359 0.0002818412 8.813751e-01 9.715347e-01 3 37065810 37065942 133 - 2.170 2.185 0.048
ENSG00000093167 E015 16.8868564 0.0268914457 1.420029e-07 1.318158e-04 3 37065943 37066223 281 - 0.839 1.482 2.310
ENSG00000093167 E016 16.6101127 0.0052316593 2.778121e-11 1.438624e-07 3 37066224 37066325 102 - 0.838 1.477 2.301
ENSG00000093167 E017 59.0680903 0.0769287933 2.050968e-06 9.931620e-04 3 37066326 37068763 2438 - 1.314 2.019 2.400
ENSG00000093167 E018 2.7727989 0.0083785433 4.907080e-01 8.248437e-01 3 37072790 37072846 57 - 0.511 0.626 0.526
ENSG00000093167 E019 2.8111440 0.0070793097 1.641592e-01 5.593066e-01 3 37072847 37072882 36 - 0.471 0.694 1.009
ENSG00000093167 E020 114.5724753 0.0003349064 6.381588e-02 3.814061e-01 3 37075024 37075116 93 - 2.092 2.041 -0.170
ENSG00000093167 E021 64.5108674 0.0005045162 6.869781e-02 3.929393e-01 3 37083636 37083644 9 - 1.851 1.782 -0.234
ENSG00000093167 E022 154.3132856 0.0005067421 1.102871e-01 4.760957e-01 3 37083645 37083806 162 - 2.212 2.175 -0.123
ENSG00000093167 E023 75.5945931 0.0003797551 2.962036e-01 6.966561e-01 3 37091467 37091538 72 - 1.901 1.870 -0.106
ENSG00000093167 E024 134.0916086 0.0002899933 2.194534e-01 6.241055e-01 3 37094792 37094908 117 - 2.148 2.121 -0.090
ENSG00000093167 E025 75.5544538 0.0004060137 3.617859e-01 7.480620e-01 3 37096616 37096660 45 - 1.903 1.876 -0.089
ENSG00000093167 E026 0.6797700 0.2111435629 8.684150e-01   3 37102924 37103013 90 - 0.197 0.234 0.314
ENSG00000093167 E027 1.2734517 0.1804538080 7.901013e-01   3 37105455 37105523 69 - 0.325 0.388 0.375
ENSG00000093167 E028 0.8370330 0.0164845833 1.097718e-01   3 37108073 37108129 57 - 0.107 0.386 2.354
ENSG00000093167 E029 0.4979971 0.0338906068 5.807521e-02   3 37108637 37108684 48 - 0.000 0.317 13.267
ENSG00000093167 E030 0.0000000       3 37109527 37109571 45 -      
ENSG00000093167 E031 0.4437478 0.0217089464 7.043329e-01   3 37109653 37109703 51 - 0.193 0.133 -0.644
ENSG00000093167 E032 0.4704972 0.0223127080 1.248799e-01   3 37110991 37111065 75 - 0.265 0.000 -12.725
ENSG00000093167 E033 0.3485388 0.0365019567 8.743406e-01   3 37111826 37111915 90 - 0.107 0.133 0.353
ENSG00000093167 E034 0.9098056 0.1213085793 1.842797e-01   3 37112915 37112980 66 - 0.381 0.133 -1.974
ENSG00000093167 E035 0.0000000       3 37115054 37115095 42 -      
ENSG00000093167 E036 0.2892872 0.0274424043 2.692893e-01   3 37121464 37121491 28 - 0.193 0.000 -12.138
ENSG00000093167 E037 5.2249091 0.0474082161 3.593333e-01 7.464378e-01 3 37121492 37121536 45 - 0.854 0.723 -0.521
ENSG00000093167 E038 5.4480633 0.0336554243 4.154658e-01 7.837984e-01 3 37121635 37121665 31 - 0.856 0.752 -0.412
ENSG00000093167 E039 5.3501175 0.0216310626 8.950626e-01 9.748718e-01 3 37121666 37121691 26 - 0.802 0.803 0.003
ENSG00000093167 E040 0.1717682 0.0366716432 3.999123e-01   3 37127630 37127680 51 - 0.000 0.133 11.683
ENSG00000093167 E041 98.3923301 0.0003028195 3.039362e-03 9.918267e-02 3 37129063 37129149 87 - 2.044 1.950 -0.316
ENSG00000093167 E042 1.8976129 0.0318556432 4.969131e-01 8.277418e-01 3 37146329 37146425 97 - 0.425 0.545 0.594
ENSG00000093167 E043 1.3385462 0.0483822482 5.195478e-01   3 37146426 37146453 28 - 0.324 0.446 0.689
ENSG00000093167 E044 3.5899632 0.0058763529 1.334407e-01 5.154026e-01 3 37146454 37146627 174 - 0.760 0.545 -0.923
ENSG00000093167 E045 65.9996970 0.0105923292 1.164674e-02 1.864952e-01 3 37148894 37148926 33 - 1.893 1.746 -0.494
ENSG00000093167 E046 98.4020737 0.0040444255 1.884777e-03 7.720827e-02 3 37148927 37149038 112 - 2.054 1.929 -0.423
ENSG00000093167 E047 4.1782576 0.0063279417 8.242033e-01 9.555010e-01 3 37154614 37154656 43 - 0.715 0.753 0.154
ENSG00000093167 E048 1.0475609 0.0344858557 1.629785e-01   3 37154657 37154724 68 - 0.192 0.446 1.685
ENSG00000093167 E049 16.5746360 0.0236298427 2.717562e-01 6.757571e-01 3 37170333 37171066 734 - 1.177 1.309 0.466
ENSG00000093167 E050 1.2885855 0.0422362136 3.455973e-01   3 37172770 37172790 21 - 0.265 0.446 1.088
ENSG00000093167 E051 33.8656709 0.0472380550 3.005169e-01 7.003792e-01 3 37172791 37173026 236 - 1.596 1.471 -0.429
ENSG00000093167 E052 21.6429918 0.0410845318 2.392391e-01 6.444724e-01 3 37173027 37173194 168 - 1.415 1.271 -0.501
ENSG00000093167 E053 0.5108041 0.0215469503 4.511523e-01   3 37174119 37174538 420 - 0.107 0.235 1.354
ENSG00000093167 E054 100.2436078 0.0003606741 1.585004e-03 7.021027e-02 3 37174539 37174605 67 - 2.055 1.954 -0.340
ENSG00000093167 E055 0.6602624 0.0186057742 2.252797e-02   3 37174717 37175162 446 - 0.000 0.386 13.682
ENSG00000093167 E056 0.5108041 0.0215469503 4.511523e-01   3 37175163 37175215 53 - 0.107 0.235 1.354
ENSG00000093167 E057 13.0694031 0.0835659514 7.684374e-01 9.390817e-01 3 37175818 37176059 242 - 1.183 1.116 -0.239
ENSG00000093167 E058 104.6261119 0.0003199224 2.329815e-05 5.399599e-03 3 37176060 37176360 301 - 2.086 1.950 -0.456
ENSG00000093167 E059 0.1717682 0.0366716432 3.999123e-01   3 37176369 37176532 164 - 0.000 0.133 11.683
ENSG00000093167 E060 0.0000000       3 37183542 37183689 148 -