ENSG00000092531

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000249647 ENSG00000092531 HEK293_DMSO_6hA HEK293_OSMI2_6hA SNAP23 protein_coding protein_coding 23.75378 6.792802 9.004835 1.916986 2.275706 0.4061719 19.434792 4.9539514 7.59084159 1.3467081 2.22582386 0.6146702 0.81992500 0.7338 0.8157 0.0819 0.543459713 0.002164324 FALSE  
ENST00000563333 ENSG00000092531 HEK293_DMSO_6hA HEK293_OSMI2_6hA SNAP23 protein_coding retained_intron 23.75378 6.792802 9.004835 1.916986 2.275706 0.4061719 0.091553 0.4843228 0.02383592 0.1052499 0.02383592 -3.8688261 0.01119583 0.0795 0.0024 -0.0771 0.002164324 0.002164324    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000092531 E001 0.0000000       15 42491233 42491243 11 +      
ENSG00000092531 E002 0.2920894 0.0280075969 8.485261e-01   15 42491244 42491295 52 + 0.106 0.134 0.389
ENSG00000092531 E003 0.2920894 0.0280075969 8.485261e-01   15 42491296 42491298 3 + 0.106 0.134 0.389
ENSG00000092531 E004 0.2920894 0.0280075969 8.485261e-01   15 42491299 42491334 36 + 0.106 0.134 0.389
ENSG00000092531 E005 0.1125166 0.0326491905 6.087456e-01   15 42491335 42491570 236 + 0.106 0.000 -12.005
ENSG00000092531 E006 0.1717682 0.0458057098 3.923506e-01   15 42492754 42492841 88 + 0.000 0.134 11.609
ENSG00000092531 E007 0.1717682 0.0458057098 3.923506e-01   15 42492842 42492860 19 + 0.000 0.134 11.609
ENSG00000092531 E008 0.1795728 0.0526624609 3.926644e-01   15 42492861 42492870 10 + 0.000 0.134 11.572
ENSG00000092531 E009 0.3513410 0.0362041425 1.455589e-01   15 42492871 42492945 75 + 0.000 0.237 12.636
ENSG00000092531 E010 0.0000000       15 42492946 42492957 12 +      
ENSG00000092531 E011 1.3919840 0.0123222607 1.849857e-01   15 42495306 42495633 328 + 0.469 0.237 -1.424
ENSG00000092531 E012 1.9259385 0.0098502822 3.489212e-01 0.738547630 15 42495634 42495641 8 + 0.543 0.389 -0.784
ENSG00000092531 E013 2.9064432 0.0236632101 7.602500e-01 0.935946781 15 42495642 42495643 2 + 0.633 0.590 -0.191
ENSG00000092531 E014 3.4938964 0.0217167106 3.456175e-01 0.735884878 15 42495644 42495650 7 + 0.732 0.590 -0.607
ENSG00000092531 E015 3.6064130 0.0323835278 3.022424e-01 0.701587988 15 42495651 42495652 2 + 0.752 0.590 -0.687
ENSG00000092531 E016 14.4363126 0.0526618131 6.725962e-01 0.905006361 15 42495653 42495677 25 + 1.224 1.165 -0.208
ENSG00000092531 E017 28.2228644 0.0011527955 4.578337e-01 0.807476307 15 42495678 42495708 31 + 1.498 1.455 -0.147
ENSG00000092531 E018 27.4602778 0.0011733159 5.624960e-01 0.859001922 15 42495709 42495713 5 + 1.482 1.449 -0.113
ENSG00000092531 E019 0.5058017 0.0220980018 5.448421e-02   15 42495714 42495931 218 + 0.000 0.319 13.291
ENSG00000092531 E020 0.2892872 0.0260788801 2.825612e-01   15 42505122 42505688 567 + 0.192 0.000 -13.026
ENSG00000092531 E021 31.0042150 0.0009772925 8.196922e-01 0.954457104 15 42511833 42511846 14 + 1.520 1.512 -0.029
ENSG00000092531 E022 43.3740428 0.0007925856 2.937824e-01 0.694516689 15 42511847 42511903 57 + 1.677 1.629 -0.162
ENSG00000092531 E023 0.4884942 0.0217007790 5.550001e-02   15 42511904 42512364 461 + 0.000 0.319 13.294
ENSG00000092531 E024 47.9943997 0.0028984288 2.694648e-01 0.673941332 15 42512955 42512996 42 + 1.718 1.671 -0.159
ENSG00000092531 E025 3.7067655 0.1503204782 7.679601e-01 0.938909352 15 42512997 42513173 177 + 0.617 0.723 0.451
ENSG00000092531 E026 4.4239528 0.1231944225 4.554907e-01 0.806389899 15 42513174 42513335 162 + 0.646 0.806 0.657
ENSG00000092531 E027 4.3654516 0.2020025501 1.569976e-01 0.549705532 15 42513336 42513398 63 + 0.549 0.872 1.345
ENSG00000092531 E028 39.8244057 0.0012759564 6.420480e-01 0.893339652 15 42513399 42513409 11 + 1.597 1.629 0.110
ENSG00000092531 E029 55.3790776 0.0005584885 6.351242e-01 0.890225282 15 42513410 42513447 38 + 1.764 1.748 -0.054
ENSG00000092531 E030 66.5915733 0.0005589273 6.299137e-01 0.888020552 15 42515237 42515354 118 + 1.824 1.850 0.088
ENSG00000092531 E031 0.4465501 0.0217681645 4.336023e-01   15 42521614 42521708 95 + 0.106 0.237 1.387
ENSG00000092531 E032 0.4688600 0.0230094854 7.315272e-01   15 42521709 42522095 387 + 0.192 0.134 -0.614
ENSG00000092531 E033 4.1885394 0.0462764725 9.087953e-06 0.002857601 15 42527943 42528261 319 + 0.193 0.969 3.894
ENSG00000092531 E034 69.6418614 0.0073920867 7.573124e-01 0.935025945 15 42528262 42528420 159 + 1.844 1.869 0.084
ENSG00000092531 E035 82.4664249 0.0004486474 3.746581e-01 0.756266451 15 42529675 42529819 145 + 1.939 1.912 -0.091
ENSG00000092531 E036 0.4633820 0.3139236667 1.412930e-01   15 42529820 42529820 1 + 0.000 0.315 12.511
ENSG00000092531 E037 319.8259597 0.0035683326 4.556412e-01 0.806477574 15 42531413 42533059 1647 + 2.500 2.521 0.069
ENSG00000092531 E038 2.0646999 0.0339100226 2.438556e-01 0.649068567 15 42545136 42545208 73 + 0.378 0.590 1.057
ENSG00000092531 E039 1.4510628 0.1010120054 6.796918e-01   15 42545209 42545356 148 + 0.372 0.448 0.417