ENSG00000092208

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000250379 ENSG00000092208 HEK293_DMSO_6hA HEK293_OSMI2_6hA GEMIN2 protein_coding protein_coding 28.27846 6.87223 7.019984 2.325787 1.377501 0.0306454 3.8391796 0.5511098 0.5452164 0.27645305 0.2064656 -0.01523297 0.12269583 0.08400000 0.07590000 -0.008100000 0.91505001 0.01042759 FALSE TRUE
ENST00000308317 ENSG00000092208 HEK293_DMSO_6hA HEK293_OSMI2_6hA GEMIN2 protein_coding protein_coding 28.27846 6.87223 7.019984 2.325787 1.377501 0.0306454 15.8539164 4.8162936 5.0301128 1.63322244 1.2799032 0.06254033 0.59677500 0.70096667 0.69503333 -0.005933333 1.00000000 0.01042759 FALSE TRUE
ENST00000412033 ENSG00000092208 HEK293_DMSO_6hA HEK293_OSMI2_6hA GEMIN2 protein_coding nonsense_mediated_decay 28.27846 6.87223 7.019984 2.325787 1.377501 0.0306454 1.6255152 0.2094900 0.3357555 0.14552349 0.1376842 0.65559739 0.05951667 0.02460000 0.04606667 0.021466667 0.74957775 0.01042759 FALSE TRUE
ENST00000524980 ENSG00000092208 HEK293_DMSO_6hA HEK293_OSMI2_6hA GEMIN2 protein_coding retained_intron 28.27846 6.87223 7.019984 2.325787 1.377501 0.0306454 0.2549104 0.3528005 0.0000000 0.09516585 0.0000000 -5.18110471 0.01317083 0.06733333 0.00000000 -0.067333333 0.01042759 0.01042759   FALSE
ENST00000531684 ENSG00000092208 HEK293_DMSO_6hA HEK293_OSMI2_6hA GEMIN2 protein_coding nonsense_mediated_decay 28.27846 6.87223 7.019984 2.325787 1.377501 0.0306454 0.8213655 0.2134480 0.3082271 0.21344796 0.3082271 0.51011768 0.02908750 0.01853333 0.07070000 0.052166667 0.99486592 0.01042759 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000092208 E001 0.5512620 0.0209058405 0.936554522   14 39114267 39114284 18 + 0.207 0.219 0.109
ENSG00000092208 E002 2.2024187 0.0090747373 0.255026129 0.66074807 14 39114285 39114305 21 + 0.608 0.422 -0.894
ENSG00000092208 E003 3.3634439 0.0064516350 0.034338164 0.29508913 14 39114306 39114316 11 + 0.791 0.473 -1.396
ENSG00000092208 E004 3.3634439 0.0064516350 0.034338164 0.29508913 14 39114317 39114319 3 + 0.791 0.473 -1.396
ENSG00000092208 E005 3.3634439 0.0064516350 0.034338164 0.29508913 14 39114320 39114322 3 + 0.791 0.473 -1.396
ENSG00000092208 E006 3.3634439 0.0064516350 0.034338164 0.29508913 14 39114323 39114323 1 + 0.791 0.473 -1.396
ENSG00000092208 E007 5.2042392 0.0051386702 0.007957532 0.15590910 14 39114324 39114330 7 + 0.951 0.597 -1.424
ENSG00000092208 E008 25.4968068 0.0013010340 0.109505309 0.47482118 14 39114331 39114395 65 + 1.490 1.386 -0.359
ENSG00000092208 E009 27.0090585 0.0010544998 0.723265200 0.92329155 14 39114396 39114420 25 + 1.473 1.451 -0.074
ENSG00000092208 E010 30.6786281 0.0012329116 0.667518056 0.90311683 14 39114421 39114466 46 + 1.530 1.503 -0.093
ENSG00000092208 E011 27.3120137 0.0010540988 0.682241734 0.90902479 14 39114467 39114475 9 + 1.477 1.451 -0.089
ENSG00000092208 E012 48.9098412 0.0006325744 0.633215543 0.88927861 14 39114829 39114913 85 + 1.721 1.698 -0.076
ENSG00000092208 E013 48.2733670 0.0007033293 0.494716321 0.82661198 14 39117999 39118088 90 + 1.716 1.684 -0.109
ENSG00000092208 E014 36.8011030 0.0066672144 0.414651313 0.78317932 14 39118540 39118599 60 + 1.601 1.560 -0.139
ENSG00000092208 E015 0.3262289 0.0274424043 0.190238894   14 39121907 39122024 118 + 0.000 0.219 9.254
ENSG00000092208 E016 62.0523815 0.0039353038 0.737499798 0.92816199 14 39122430 39122543 114 + 1.807 1.802 -0.017
ENSG00000092208 E017 0.4856919 0.0735735348 0.580116594   14 39122544 39122701 158 + 0.116 0.219 1.091
ENSG00000092208 E018 40.2594958 0.0008254316 0.230521763 0.63543035 14 39124992 39125036 45 + 1.653 1.592 -0.208
ENSG00000092208 E019 46.7846731 0.0006582290 0.697295401 0.91408834 14 39128280 39128348 69 + 1.681 1.701 0.067
ENSG00000092208 E020 1.5027733 0.1297686218 0.332380029   14 39131773 39131786 14 + 0.284 0.475 1.105
ENSG00000092208 E021 2.8629155 0.1914456505 0.088489234 0.43516276 14 39131787 39131957 171 + 0.351 0.725 1.791
ENSG00000092208 E022 61.9089605 0.0006749470 0.425404657 0.78950472 14 39131958 39132068 111 + 1.794 1.828 0.114
ENSG00000092208 E023 48.2496153 0.0008924789 0.026104242 0.26272140 14 39133661 39133719 59 + 1.649 1.757 0.365
ENSG00000092208 E024 0.9841036 0.0176235729 0.933449549   14 39133720 39133759 40 + 0.283 0.298 0.103
ENSG00000092208 E025 0.7107251 0.0197637390 0.709999699   14 39133760 39133820 61 + 0.282 0.219 -0.480
ENSG00000092208 E026 0.8874957 0.0500804078 0.458600776   14 39133821 39134370 550 + 0.346 0.219 -0.897
ENSG00000092208 E027 1.7827418 0.1303373297 0.099211382 0.45582441 14 39135931 39136155 225 + 0.210 0.592 2.225
ENSG00000092208 E028 83.7819635 0.0004135862 0.001761769 0.07462059 14 39136440 39136973 534 + 1.876 1.989 0.379