ENSG00000091136

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000222399 ENSG00000091136 HEK293_DMSO_6hA HEK293_OSMI2_6hA LAMB1 protein_coding protein_coding 13.55961 9.59505 13.8516 2.173869 2.932175 0.5292283 8.979305 4.797646 10.143773 0.7525029 2.177566 1.0786135 0.69742917 0.5141333 0.7352333 0.2211 0.01776654 0.01776654 FALSE TRUE
ENST00000491196 ENSG00000091136 HEK293_DMSO_6hA HEK293_OSMI2_6hA LAMB1 protein_coding retained_intron 13.55961 9.59505 13.8516 2.173869 2.932175 0.5292283 1.013630 1.328550 0.000000 1.0054765 0.000000 -7.0645271 0.05910417 0.1112000 0.0000000 -0.1112 0.18488764 0.01776654 FALSE FALSE
ENST00000676744 ENSG00000091136 HEK293_DMSO_6hA HEK293_OSMI2_6hA LAMB1 protein_coding retained_intron 13.55961 9.59505 13.8516 2.173869 2.932175 0.5292283 2.227724 1.669943 2.139832 0.3891981 1.211987 0.3558121 0.13242917 0.1796000 0.1300000 -0.0496 0.74796145 0.01776654 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000091136 E001 108.0028389 0.0031260151 5.736985e-03 0.13507672 7 107923799 107924087 289 - 1.978 2.096 0.397
ENSG00000091136 E002 115.7175417 0.0067980179 5.772818e-01 0.86553673 7 107924230 107924389 160 - 2.048 2.078 0.099
ENSG00000091136 E003 3.5125100 0.0161413644 3.193776e-03 0.10178475 7 107924390 107926182 1793 - 0.395 0.853 2.050
ENSG00000091136 E004 115.0268756 0.0034136004 1.687085e-01 0.56558930 7 107926183 107926359 177 - 2.083 2.022 -0.204
ENSG00000091136 E005 3.5479655 0.0060884280 1.051122e-03 0.05584497 7 107926360 107928645 2286 - 0.393 0.877 2.149
ENSG00000091136 E006 0.0000000       7 107928857 107929021 165 -      
ENSG00000091136 E007 0.0000000       7 107929022 107929063 42 -      
ENSG00000091136 E008 44.4633624 0.0126673012 2.102569e-01 0.61455680 7 107929064 107929065 2 - 1.689 1.587 -0.345
ENSG00000091136 E009 126.5377597 0.0093659021 5.136420e-01 0.83695734 7 107929066 107929205 140 - 2.114 2.075 -0.132
ENSG00000091136 E010 0.1544607 0.0328009693 3.047598e-01   7 107929206 107929411 206 - 0.000 0.149 12.136
ENSG00000091136 E011 147.8806481 0.0002866523 8.199300e-01 0.95451043 7 107929412 107929619 208 - 2.174 2.167 -0.023
ENSG00000091136 E012 1.7713878 0.0101597906 2.637256e-01 0.66863075 7 107929620 107929792 173 - 0.348 0.538 0.997
ENSG00000091136 E013 0.4716622 0.2165521074 3.609856e-01   7 107931217 107931355 139 - 0.094 0.261 1.773
ENSG00000091136 E014 121.9029701 0.0030609345 5.927731e-01 0.87251734 7 107931356 107931500 145 - 2.095 2.074 -0.070
ENSG00000091136 E015 2.7680104 0.0101283335 2.354899e-04 0.02258264 7 107931501 107931738 238 - 0.240 0.827 2.954
ENSG00000091136 E016 141.9173375 0.0037576546 5.795366e-01 0.86667905 7 107932174 107932377 204 - 2.159 2.139 -0.067
ENSG00000091136 E017 1.9572512 0.4998181209 1.161918e-01 0.48660226 7 107932378 107932406 29 - 0.182 0.695 2.928
ENSG00000091136 E018 2.7009541 0.0130642880 1.707840e-03 0.07339329 7 107932407 107932493 87 - 0.297 0.800 2.433
ENSG00000091136 E019 10.3493260 0.0620602837 5.558792e-04 0.03847710 7 107932494 107934799 2306 - 0.742 1.285 2.018
ENSG00000091136 E020 0.3340335 0.0274424043 9.892830e-02   7 107935356 107935358 3 - 0.000 0.259 13.137
ENSG00000091136 E021 0.4884942 0.0228744521 3.218744e-02   7 107935359 107935373 15 - 0.000 0.347 13.722
ENSG00000091136 E022 0.7974156 0.1828242240 1.340393e-02   7 107935374 107935391 18 - 0.000 0.480 14.439
ENSG00000091136 E023 1.5969439 0.0129977458 7.294959e-03   7 107935392 107935414 23 - 0.174 0.630 2.733
ENSG00000091136 E024 138.1939079 0.0039632805 9.517934e-01 0.98875591 7 107935415 107935656 242 - 2.141 2.142 0.006
ENSG00000091136 E025 0.3262289 0.0274424043 9.883329e-02   7 107935657 107936278 622 - 0.000 0.259 13.137
ENSG00000091136 E026 0.0000000       7 107936279 107936373 95 -      
ENSG00000091136 E027 0.6870118 0.0185723778 1.343632e-01   7 107936374 107937092 719 - 0.096 0.348 2.317
ENSG00000091136 E028 110.7621474 0.0003079451 6.166936e-01 0.88273138 7 107937093 107937277 185 - 2.055 2.039 -0.057
ENSG00000091136 E029 0.0000000       7 107937278 107937318 41 -      
ENSG00000091136 E030 124.2557946 0.0003083754 3.122110e-01 0.70998871 7 107939989 107940358 370 - 2.110 2.077 -0.109
ENSG00000091136 E031 11.2554703 0.0224740630 3.452148e-06 0.00141597 7 107940359 107941802 1444 - 0.756 1.323 2.092
ENSG00000091136 E032 7.3310544 0.0034831265 1.100497e-03 0.05707736 7 107942436 107942619 184 - 0.714 1.095 1.454
ENSG00000091136 E033 1.8183343 0.0182037633 2.800340e-01 0.68321969 7 107950623 107951158 536 - 0.349 0.538 0.991
ENSG00000091136 E034 0.8715870 0.0284236524 3.281321e-01   7 107951159 107951225 67 - 0.174 0.348 1.314
ENSG00000091136 E035 56.5747370 0.0005458454 7.278373e-01 0.92497655 7 107951226 107951322 97 - 1.752 1.768 0.055
ENSG00000091136 E036 96.2925237 0.0003415740 8.414747e-01 0.96077347 7 107952009 107952223 215 - 1.988 1.981 -0.022
ENSG00000091136 E037 101.1537340 0.0057218936 7.484743e-01 0.93219107 7 107953530 107953754 225 - 2.011 2.001 -0.035
ENSG00000091136 E038 78.5923298 0.0017311244 4.767595e-01 0.81761960 7 107955467 107955630 164 - 1.913 1.882 -0.105
ENSG00000091136 E039 0.1767706 0.0511725162 7.484005e-01   7 107958293 107958508 216 - 0.096 0.000 -10.843
ENSG00000091136 E040 94.2173971 0.0143497953 6.422118e-01 0.89340454 7 107959249 107959480 232 - 1.981 1.956 -0.084
ENSG00000091136 E041 0.3563434 0.0373573562 7.180608e-01   7 107959506 107959690 185 - 0.096 0.149 0.731
ENSG00000091136 E042 73.4078903 0.0046081298 1.717262e-01 0.56920646 7 107959691 107959834 144 - 1.892 1.823 -0.233
ENSG00000091136 E043 102.6051376 0.0002756896 7.017332e-02 0.39614196 7 107960445 107960649 205 - 2.038 1.974 -0.213
ENSG00000091136 E044 71.8039590 0.0004609550 3.601620e-01 0.74691913 7 107961206 107961329 124 - 1.871 1.833 -0.128
ENSG00000091136 E045 62.9025967 0.0013496568 5.689986e-01 0.86197342 7 107961549 107961676 128 - 1.807 1.783 -0.082
ENSG00000091136 E046 66.1846209 0.0118196360 9.307198e-01 0.98343516 7 107962905 107963063 159 - 1.817 1.823 0.020
ENSG00000091136 E047 64.0229944 0.0036681384 3.772020e-01 0.75817861 7 107964552 107964687 136 - 1.787 1.837 0.168
ENSG00000091136 E048 55.3585843 0.0044915029 5.267263e-01 0.84334000 7 107972992 107973071 80 - 1.730 1.770 0.137
ENSG00000091136 E049 58.1959154 0.0005848626 2.556793e-01 0.66142989 7 107974986 107975098 113 - 1.745 1.797 0.178
ENSG00000091136 E050 0.0000000       7 107975230 107975233 4 -      
ENSG00000091136 E051 80.5968321 0.0003592869 5.471721e-01 0.85278904 7 107975234 107975413 180 - 1.917 1.893 -0.078
ENSG00000091136 E052 83.9556279 0.0004053702 2.430924e-01 0.64817205 7 107975689 107975877 189 - 1.945 1.900 -0.151
ENSG00000091136 E053 59.8568893 0.0010548717 4.444595e-01 0.80028441 7 107978047 107978167 121 - 1.796 1.762 -0.117
ENSG00000091136 E054 59.9696031 0.0071209562 5.171428e-01 0.83873641 7 107980609 107980811 203 - 1.791 1.760 -0.103
ENSG00000091136 E055 35.0517650 0.0084927388 8.817895e-01 0.97168055 7 107986022 107986085 64 - 1.550 1.547 -0.012
ENSG00000091136 E056 57.4827190 0.0075376823 8.207511e-01 0.95465854 7 107986175 107986363 189 - 1.755 1.778 0.079
ENSG00000091136 E057 34.8372771 0.0038421127 3.646048e-01 0.75005986 7 107994887 107994960 74 - 1.529 1.590 0.211
ENSG00000091136 E058 29.3505203 0.0009263617 7.684395e-01 0.93908166 7 107998357 107998397 41 - 1.484 1.465 -0.064
ENSG00000091136 E059 39.2378948 0.0008008002 4.691581e-01 0.81360309 7 107998398 107998492 95 - 1.618 1.577 -0.139
ENSG00000091136 E060 42.8330970 0.0007221822 9.617534e-01 0.99119721 7 108001558 108001733 176 - 1.636 1.639 0.009
ENSG00000091136 E061 2.7240607 0.1440987729 1.618581e-01 0.55664426 7 108001734 108001946 213 - 0.406 0.705 1.395
ENSG00000091136 E062 1.4771856 0.2209816664 8.335646e-02   7 108001947 108001998 52 - 0.177 0.582 2.481
ENSG00000091136 E063 2.0473924 0.0410975583 1.187664e-01 0.49141244 7 108001999 108002126 128 - 0.348 0.629 1.404
ENSG00000091136 E064 3.6256207 0.4326285255 4.024509e-01 0.77509333 7 108002127 108002384 258 - 0.485 0.826 1.471
ENSG00000091136 E065 6.2475922 0.2484128511 2.290952e-01 0.63423400 7 108002385 108002848 464 - 0.738 0.981 0.939
ENSG00000091136 E066 27.5426084 0.0053478907 3.336803e-01 0.72738762 7 108002849 108002971 123 - 1.429 1.495 0.228
ENSG00000091136 E067 2.6787150 0.0090147785 1.820511e-02 0.22700440 7 108002972 108003110 139 - 0.672 0.259 -2.177
ENSG00000091136 E068 12.2625257 0.0506927273 9.217405e-01 0.98125136 7 108003111 108003213 103 - 1.138 1.122 -0.058