ENSG00000091127

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000356362 ENSG00000091127 HEK293_DMSO_6hA HEK293_OSMI2_6hA PUS7 protein_coding protein_coding 21.60719 7.416059 9.976679 2.01188 1.566892 0.4274082 8.477792 4.5281923 3.1237810 1.21580603 1.3395599 -0.5342134 0.39807500 0.61243333 0.28526667 -0.32716667 5.507558e-02 3.022376e-26 FALSE TRUE
ENST00000469408 ENSG00000091127 HEK293_DMSO_6hA HEK293_OSMI2_6hA PUS7 protein_coding protein_coding 21.60719 7.416059 9.976679 2.01188 1.566892 0.4274082 5.043022 0.0000000 3.4816737 0.00000000 0.4994222 8.4477750 0.26718750 0.00000000 0.35473333 0.35473333 3.022376e-26 3.022376e-26 FALSE TRUE
ENST00000487277 ENSG00000091127 HEK293_DMSO_6hA HEK293_OSMI2_6hA PUS7 protein_coding retained_intron 21.60719 7.416059 9.976679 2.01188 1.566892 0.4274082 2.146049 1.2510302 1.5530907 0.28586324 0.1905783 0.3097986 0.10405000 0.17206667 0.17086667 -0.00120000 9.616133e-01 3.022376e-26   FALSE
MSTRG.30446.5 ENSG00000091127 HEK293_DMSO_6hA HEK293_OSMI2_6hA PUS7 protein_coding   21.60719 7.416059 9.976679 2.01188 1.566892 0.4274082 1.110462 0.5369141 0.4696521 0.08349231 0.1031978 -0.1893256 0.05724167 0.07743333 0.05316667 -0.02426667 7.488757e-01 3.022376e-26 TRUE TRUE
MSTRG.30446.7 ENSG00000091127 HEK293_DMSO_6hA HEK293_OSMI2_6hA PUS7 protein_coding   21.60719 7.416059 9.976679 2.01188 1.566892 0.4274082 1.839824 0.4298273 0.5629674 0.24481737 0.2859510 0.3815156 0.06519583 0.05120000 0.06143333 0.01023333 9.859939e-01 3.022376e-26 TRUE TRUE
MSTRG.30446.8 ENSG00000091127 HEK293_DMSO_6hA HEK293_OSMI2_6hA PUS7 protein_coding   21.60719 7.416059 9.976679 2.01188 1.566892 0.4274082 1.754908 0.0000000 0.0000000 0.00000000 0.0000000 0.0000000 0.05141667 0.00000000 0.00000000 0.00000000   3.022376e-26 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000091127 E001 0.0000000       7 105439661 105439858 198 -      
ENSG00000091127 E002 0.8717381 0.0162778850 0.189584249   7 105456503 105456510 8 - 0.371 0.137 -1.861
ENSG00000091127 E003 142.8159490 0.0051729332 0.036740537 0.30295237 7 105456511 105457320 810 - 2.120 2.204 0.282
ENSG00000091127 E004 67.5640197 0.0029658868 0.258289836 0.66395121 7 105457321 105457458 138 - 1.820 1.872 0.175
ENSG00000091127 E005 51.7232047 0.0005951557 0.515234460 0.83780392 7 105457459 105457554 96 - 1.714 1.748 0.114
ENSG00000091127 E006 36.3388332 0.0008251993 0.414541404 0.78311144 7 105457555 105457697 143 - 1.598 1.555 -0.146
ENSG00000091127 E007 90.7889690 0.0010949880 0.951091757 0.98856201 7 105457698 105457926 229 - 1.963 1.970 0.025
ENSG00000091127 E008 68.3885295 0.0006328421 0.804160433 0.94963516 7 105459168 105459259 92 - 1.838 1.852 0.049
ENSG00000091127 E009 0.0000000       7 105462214 105462427 214 -      
ENSG00000091127 E010 83.0565236 0.0003634915 0.910651518 0.97861488 7 105462621 105462750 130 - 1.933 1.933 -0.002
ENSG00000091127 E011 63.4242661 0.0005113995 0.355846831 0.74399161 7 105465313 105465414 102 - 1.836 1.799 -0.122
ENSG00000091127 E012 52.1518949 0.0005991834 0.803156672 0.94920078 7 105468337 105468428 92 - 1.723 1.739 0.053
ENSG00000091127 E013 35.2028121 0.0041286584 0.690586764 0.91197111 7 105468429 105468463 35 - 1.542 1.576 0.117
ENSG00000091127 E014 3.8446427 0.0070126123 0.001583469 0.07021027 7 105470286 105470687 402 - 0.419 0.885 2.043
ENSG00000091127 E015 30.6864645 0.0010664988 0.466758914 0.81220159 7 105470688 105470760 73 - 1.527 1.487 -0.138
ENSG00000091127 E016 40.1620265 0.0007643210 0.864505275 0.96697365 7 105470761 105470848 88 - 1.624 1.618 -0.021
ENSG00000091127 E017 41.4859097 0.0006954200 0.697985616 0.91438659 7 105472132 105472193 62 - 1.643 1.625 -0.059
ENSG00000091127 E018 65.2201000 0.0048208758 0.781874940 0.94276837 7 105481052 105481177 126 - 1.814 1.841 0.091
ENSG00000091127 E019 66.1616888 0.0067737837 0.739329827 0.92893448 7 105482312 105482440 129 - 1.834 1.831 -0.010
ENSG00000091127 E020 31.4562638 0.0010158177 0.908925168 0.97816002 7 105491540 105491548 9 - 1.520 1.518 -0.010
ENSG00000091127 E021 39.1355787 0.0009608772 0.875334636 0.97007363 7 105491549 105491585 37 - 1.601 1.614 0.043
ENSG00000091127 E022 38.5086444 0.0128799378 0.314015584 0.71145149 7 105491586 105491617 32 - 1.554 1.639 0.291
ENSG00000091127 E023 52.4907149 0.0033782787 0.766383246 0.93821992 7 105495142 105495253 112 - 1.722 1.744 0.075
ENSG00000091127 E024 9.5892646 0.0543124309 0.209496217 0.61371510 7 105495254 105495347 94 - 0.931 1.120 0.694
ENSG00000091127 E025 9.0465166 0.0766718851 0.354386456 0.74280643 7 105502277 105502419 143 - 0.924 1.072 0.546
ENSG00000091127 E026 64.1197478 0.0006715273 0.148737395 0.53743104 7 105502420 105502564 145 - 1.847 1.789 -0.197
ENSG00000091127 E027 56.2152894 0.0006524832 0.270174109 0.67450799 7 105505955 105506056 102 - 1.789 1.742 -0.158
ENSG00000091127 E028 45.1425386 0.0028484715 0.957655845 0.99034804 7 105506189 105506273 85 - 1.676 1.678 0.008
ENSG00000091127 E029 94.8116906 0.0027954964 0.078117674 0.41378418 7 105508115 105508520 406 - 2.022 1.951 -0.237
ENSG00000091127 E030 8.9207346 0.0045433457 0.004905388 0.12563631 7 105508521 105508544 24 - 1.111 0.792 -1.195
ENSG00000091127 E031 25.8674819 0.0074618378 0.040737601 0.31664294 7 105522052 105522271 220 - 1.502 1.345 -0.542