ENSG00000090060

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000216277 ENSG00000090060 HEK293_DMSO_6hA HEK293_OSMI2_6hA PAPOLA protein_coding protein_coding 50.67236 16.11847 17.28046 5.169662 3.431612 0.1003671 26.1394636 5.942798 8.5956100 1.8730273 1.86714505 0.5317095 0.48280417 0.37250000 0.50783333 0.13533333 0.3881826412 0.0001597681 FALSE TRUE
ENST00000392990 ENSG00000090060 HEK293_DMSO_6hA HEK293_OSMI2_6hA PAPOLA protein_coding protein_coding 50.67236 16.11847 17.28046 5.169662 3.431612 0.1003671 9.7364481 1.736081 2.2392434 0.9409898 1.06353812 0.3653194 0.15322083 0.09533333 0.12283333 0.02750000 0.8385523654 0.0001597681 FALSE TRUE
ENST00000555508 ENSG00000090060 HEK293_DMSO_6hA HEK293_OSMI2_6hA PAPOLA protein_coding retained_intron 50.67236 16.11847 17.28046 5.169662 3.431612 0.1003671 0.5501664 1.244637 0.1904669 0.4994401 0.04090424 -2.6458344 0.01584167 0.07383333 0.01156667 -0.06226667 0.0001597681 0.0001597681   FALSE
ENST00000556459 ENSG00000090060 HEK293_DMSO_6hA HEK293_OSMI2_6hA PAPOLA protein_coding protein_coding 50.67236 16.11847 17.28046 5.169662 3.431612 0.1003671 4.5593492 2.760746 2.1434451 0.7903400 1.15967379 -0.3636279 0.12544583 0.17660000 0.10320000 -0.07340000 0.7362344675 0.0001597681 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000090060 E001 0.0000000       14 96500742 96501432 691 +      
ENSG00000090060 E002 0.0000000       14 96501433 96501589 157 +      
ENSG00000090060 E003 0.5108041 0.0217541936 4.960982e-01   14 96501590 96502375 786 + 0.111 0.228 1.248
ENSG00000090060 E004 0.3563434 0.0516417449 9.189916e-01   14 96502376 96502381 6 + 0.111 0.129 0.247
ENSG00000090060 E005 1.4039043 0.0271047426 2.410915e-01   14 96502382 96502397 16 + 0.272 0.488 1.254
ENSG00000090060 E006 2.1536839 0.0087492765 4.269924e-01 0.790385501 14 96502398 96502400 3 + 0.438 0.576 0.668
ENSG00000090060 E007 3.4769744 0.0063119159 7.896363e-01 0.944846431 14 96502401 96502411 11 + 0.678 0.649 -0.125
ENSG00000090060 E008 10.4937567 0.0422735070 6.804364e-01 0.908341565 14 96502412 96502440 29 + 1.112 1.040 -0.259
ENSG00000090060 E009 28.6696132 0.0092685029 2.847147e-01 0.687356259 14 96502441 96502541 101 + 1.519 1.440 -0.272
ENSG00000090060 E010 25.2290326 0.0163934241 8.468347e-02 0.427161349 14 96502542 96502557 16 + 1.495 1.343 -0.524
ENSG00000090060 E011 55.1643707 0.0107955780 1.470925e-01 0.535140734 14 96502558 96502600 43 + 1.792 1.702 -0.306
ENSG00000090060 E012 0.0000000       14 96502851 96502954 104 +      
ENSG00000090060 E013 0.6378259 0.1026353248 4.112653e-01   14 96504289 96504699 411 + 0.273 0.129 -1.340
ENSG00000090060 E014 142.8466602 0.0046587061 1.792616e-01 0.578271960 14 96520055 96520228 174 + 2.184 2.134 -0.170
ENSG00000090060 E015 0.4214379 0.0277291052 5.000389e-01   14 96520964 96521005 42 + 0.111 0.228 1.252
ENSG00000090060 E016 80.3710511 0.0010571235 3.565827e-01 0.744425737 14 96521006 96521015 10 + 1.925 1.902 -0.078
ENSG00000090060 E017 104.3768200 0.0029973289 6.159753e-01 0.882568156 14 96521016 96521062 47 + 2.032 2.022 -0.035
ENSG00000090060 E018 67.1648356 0.0059660057 8.080189e-01 0.950794524 14 96521063 96521072 10 + 1.842 1.834 -0.027
ENSG00000090060 E019 109.1002832 0.0004614862 6.459673e-01 0.894758060 14 96525310 96525391 82 + 2.051 2.049 -0.007
ENSG00000090060 E020 1.2902227 0.0145510488 8.623715e-01   14 96525981 96527429 1449 + 0.335 0.377 0.246
ENSG00000090060 E021 69.4051492 0.0004510263 8.523948e-01 0.963473093 14 96527430 96527441 12 + 1.851 1.858 0.024
ENSG00000090060 E022 132.6660203 0.0002828164 7.693070e-01 0.939293840 14 96527442 96527539 98 + 2.129 2.135 0.019
ENSG00000090060 E023 1.3846522 0.5367032491 6.791423e-01   14 96527540 96527952 413 + 0.355 0.378 0.137
ENSG00000090060 E024 118.5064384 0.0036695370 9.959958e-01 0.998925468 14 96527953 96528006 54 + 2.071 2.088 0.057
ENSG00000090060 E025 136.2526127 0.0009285983 4.381584e-01 0.796703649 14 96531475 96531586 112 + 2.145 2.134 -0.035
ENSG00000090060 E026 17.2199872 0.0207625171 9.747643e-01 0.994074789 14 96531587 96532248 662 + 1.250 1.261 0.040
ENSG00000090060 E027 105.6857522 0.0004628877 6.269445e-01 0.886780631 14 96532331 96532420 90 + 2.037 2.035 -0.008
ENSG00000090060 E028 103.7546286 0.0007170404 8.792309e-01 0.970973176 14 96532511 96532649 139 + 2.026 2.035 0.029
ENSG00000090060 E029 13.1471583 0.0288613071 2.531333e-01 0.658920671 14 96532650 96534222 1573 + 1.076 1.233 0.560
ENSG00000090060 E030 5.4666988 0.0044358478 4.982205e-04 0.035958022 14 96534223 96534490 268 + 0.522 0.999 1.950
ENSG00000090060 E031 48.5041160 0.0065198472 4.512876e-01 0.804316234 14 96534491 96534563 73 + 1.670 1.737 0.224
ENSG00000090060 E032 7.1300631 0.0031914100 8.604233e-01 0.965778959 14 96534564 96534889 326 + 0.901 0.935 0.125
ENSG00000090060 E033 2.4423147 0.0538544281 1.953204e-01 0.598246768 14 96535525 96535878 354 + 0.392 0.647 1.227
ENSG00000090060 E034 57.4007658 0.0075051086 4.902972e-01 0.824621527 14 96535879 96535999 121 + 1.789 1.763 -0.090
ENSG00000090060 E035 0.4856919 0.0563537168 5.239507e-01   14 96536895 96536975 81 + 0.111 0.228 1.240
ENSG00000090060 E036 53.9235190 0.0022068058 7.433320e-01 0.930443831 14 96536976 96537060 85 + 1.752 1.752 0.000
ENSG00000090060 E037 8.8275807 0.0484613746 2.899055e-01 0.691357934 14 96537061 96537901 841 + 0.884 1.099 0.797
ENSG00000090060 E038 1.0449924 0.0170245953 8.711958e-01   14 96541907 96542181 275 + 0.273 0.309 0.245
ENSG00000090060 E039 1.0276849 0.0310430916 8.899020e-01   14 96542182 96542242 61 + 0.274 0.309 0.239
ENSG00000090060 E040 43.2479700 0.0007193429 4.809558e-01 0.819717841 14 96542243 96542296 54 + 1.663 1.642 -0.072
ENSG00000090060 E041 1.4636281 0.0143784638 8.843672e-01   14 96542297 96542728 432 + 0.390 0.377 -0.077
ENSG00000090060 E042 0.2669773 0.0274424043 9.179861e-01   14 96542729 96542773 45 + 0.111 0.129 0.253
ENSG00000090060 E043 65.1303538 0.0005169484 8.651793e-01 0.967126656 14 96542774 96542893 120 + 1.816 1.839 0.077
ENSG00000090060 E044 62.1365598 0.0005665127 4.710714e-01 0.814313202 14 96544149 96544258 110 + 1.814 1.798 -0.055
ENSG00000090060 E045 0.3262289 0.0274424043 1.689635e-01   14 96547688 96547796 109 + 0.000 0.228 16.673
ENSG00000090060 E046 65.6602802 0.0031831771 5.369266e-01 0.848389738 14 96547797 96547895 99 + 1.836 1.826 -0.032
ENSG00000090060 E047 35.8310181 0.0008652904 4.483861e-01 0.802764774 14 96547896 96547918 23 + 1.591 1.563 -0.096
ENSG00000090060 E048 86.7653681 0.0037480388 2.145254e-01 0.619050925 14 96552480 96552622 143 + 1.967 1.930 -0.125
ENSG00000090060 E049 1.2612731 0.0130126496 1.675993e-02   14 96552623 96553532 910 + 0.111 0.534 3.058
ENSG00000090060 E050 35.1962911 0.0063816661 7.448705e-01 0.931096541 14 96555847 96555849 3 + 1.569 1.569 0.000
ENSG00000090060 E051 81.2897321 0.0009760606 7.504347e-01 0.932624867 14 96555850 96555947 98 + 1.909 1.939 0.101
ENSG00000090060 E052 0.0000000       14 96555948 96555950 3 +      
ENSG00000090060 E053 132.7845269 0.0002542831 8.339721e-01 0.958225119 14 96556175 96556413 239 + 2.124 2.146 0.072
ENSG00000090060 E054 2.1016679 0.8144733104 9.670260e-01 0.992453460 14 96560438 96560648 211 + 0.360 0.595 1.187
ENSG00000090060 E055 50.8345005 0.0006044265 3.337692e-01 0.727500634 14 96560649 96560711 63 + 1.738 1.705 -0.110
ENSG00000090060 E056 7.8030293 0.0035740954 4.185403e-06 0.001650682 14 96562458 96562818 361 + 0.592 1.160 2.212
ENSG00000090060 E057 63.6962427 0.0004216324 1.622821e-02 0.216032707 14 96562819 96562893 75 + 1.858 1.769 -0.303
ENSG00000090060 E058 875.3587288 0.0095199356 1.417630e-01 0.527683292 14 96564955 96567116 2162 + 2.911 2.975 0.211