ENSG00000087266

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000435136 ENSG00000087266 HEK293_DMSO_6hA HEK293_OSMI2_6hA SH3BP2 protein_coding protein_coding 12.1023 15.61872 17.72889 1.489213 1.557153 0.1827162 0.7220164 2.050018 0.2882196 0.2922574 0.2882196 -2.78821003 0.05622083 0.13603333 0.01400000 -0.122033333 0.1068994614 0.0007556647 FALSE TRUE
ENST00000504450 ENSG00000087266 HEK293_DMSO_6hA HEK293_OSMI2_6hA SH3BP2 protein_coding retained_intron 12.1023 15.61872 17.72889 1.489213 1.557153 0.1827162 0.6321167 0.829504 0.6683122 0.2482666 0.4336373 -0.30758774 0.05262083 0.05113333 0.03543333 -0.015700000 0.7489936780 0.0007556647 FALSE TRUE
ENST00000505941 ENSG00000087266 HEK293_DMSO_6hA HEK293_OSMI2_6hA SH3BP2 protein_coding retained_intron 12.1023 15.61872 17.72889 1.489213 1.557153 0.1827162 0.6915170 1.120404 0.5708669 0.3846483 0.2866800 -0.96055893 0.05826667 0.07366667 0.03016667 -0.043500000 0.7113440809 0.0007556647 FALSE FALSE
ENST00000511185 ENSG00000087266 HEK293_DMSO_6hA HEK293_OSMI2_6hA SH3BP2 protein_coding retained_intron 12.1023 15.61872 17.72889 1.489213 1.557153 0.1827162 1.2150172 1.443834 1.5152099 0.9485832 1.2023152 0.06914518 0.10590000 0.08523333 0.08906667 0.003833333 0.9854753018 0.0007556647 TRUE TRUE
ENST00000511663 ENSG00000087266 HEK293_DMSO_6hA HEK293_OSMI2_6hA SH3BP2 protein_coding retained_intron 12.1023 15.61872 17.72889 1.489213 1.557153 0.1827162 0.3569596 1.238868 0.6381410 1.2388676 0.6381410 -0.94624094 0.02771250 0.08376667 0.03100000 -0.052766667 0.9984686339 0.0007556647 TRUE TRUE
ENST00000511747 ENSG00000087266 HEK293_DMSO_6hA HEK293_OSMI2_6hA SH3BP2 protein_coding protein_coding 12.1023 15.61872 17.72889 1.489213 1.557153 0.1827162 1.5771936 1.389614 2.4459272 0.5404903 0.3280879 0.81123917 0.13193333 0.08680000 0.13803333 0.051233333 0.6593269112 0.0007556647 FALSE TRUE
MSTRG.24476.12 ENSG00000087266 HEK293_DMSO_6hA HEK293_OSMI2_6hA SH3BP2 protein_coding   12.1023 15.61872 17.72889 1.489213 1.557153 0.1827162 1.0575117 1.331345 1.6243387 0.1336448 0.1780933 0.28502667 0.08732500 0.08516667 0.09300000 0.007833333 0.9335703210 0.0007556647 FALSE TRUE
MSTRG.24476.15 ENSG00000087266 HEK293_DMSO_6hA HEK293_OSMI2_6hA SH3BP2 protein_coding   12.1023 15.61872 17.72889 1.489213 1.557153 0.1827162 2.7047596 1.742392 5.5909734 0.3837151 0.9202444 1.67635230 0.21828333 0.10906667 0.31560000 0.206533333 0.0007556647 0.0007556647 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000087266 E001 0.2937266 0.0258639384 2.244424e-01   4 2793071 2793071 1 + 0.197 0.000 -10.624
ENSG00000087266 E002 0.9634309 0.1347616182 9.269610e-01   4 2793072 2793084 13 + 0.271 0.311 0.268
ENSG00000087266 E003 1.8539626 0.1016989702 8.789868e-01 0.970932985 4 2793085 2793138 54 + 0.442 0.439 -0.013
ENSG00000087266 E004 0.0000000       4 2793724 2793757 34 +      
ENSG00000087266 E005 0.0000000       4 2794159 2794162 4 +      
ENSG00000087266 E006 0.0000000       4 2794163 2794262 100 +      
ENSG00000087266 E007 0.8140336 0.0173631824 7.234951e-01   4 2796374 2796646 273 + 0.270 0.230 -0.302
ENSG00000087266 E008 0.0000000       4 2798564 2798599 36 +      
ENSG00000087266 E009 0.0000000       4 2798998 2799068 71 +      
ENSG00000087266 E010 0.0000000       4 2799069 2799305 237 +      
ENSG00000087266 E011 0.1125166 0.0329390216 5.259895e-01   4 2809779 2809829 51 + 0.109 0.000 -11.771
ENSG00000087266 E012 0.1125166 0.0329390216 5.259895e-01   4 2811798 2811899 102 + 0.109 0.000 -11.771
ENSG00000087266 E013 3.8530130 0.0062908470 4.192271e-01 0.785651819 4 2811930 2812124 195 + 0.618 0.771 0.635
ENSG00000087266 E014 25.6347738 0.0011838142 1.664920e-02 0.218428516 4 2812280 2812289 10 + 1.473 1.356 -0.405
ENSG00000087266 E015 25.8143467 0.0011944855 2.115861e-02 0.241090007 4 2812290 2812290 1 + 1.473 1.363 -0.382
ENSG00000087266 E016 27.7346840 0.0015211715 1.179589e-02 0.187740483 4 2812291 2812300 10 + 1.509 1.388 -0.417
ENSG00000087266 E017 59.4448741 0.0005385729 2.301379e-02 0.250038781 4 2812301 2812477 177 + 1.804 1.748 -0.189
ENSG00000087266 E018 1.1357620 0.0155337467 7.984583e-01   4 2814811 2814833 23 + 0.333 0.311 -0.135
ENSG00000087266 E019 1.7763902 0.0105339642 8.800958e-01 0.971186057 4 2814834 2814917 84 + 0.435 0.439 0.019
ENSG00000087266 E020 1.5464156 0.1236044403 1.299600e-01   4 2817819 2818184 366 + 0.200 0.539 2.074
ENSG00000087266 E021 4.0125834 0.0055049890 2.400454e-01 0.645215679 4 2818185 2818338 154 + 0.748 0.618 -0.547
ENSG00000087266 E022 10.7697624 0.0269920652 1.190611e-01 0.491761949 4 2818339 2818390 52 + 1.132 0.992 -0.510
ENSG00000087266 E023 1.4843008 0.0122868195 8.430572e-01   4 2818716 2818813 98 + 0.387 0.380 -0.042
ENSG00000087266 E024 4.0644860 0.0067228172 5.411589e-01 0.850427522 4 2818814 2819070 257 + 0.648 0.770 0.507
ENSG00000087266 E025 61.6674475 0.0005136034 5.130871e-01 0.836611523 4 2820614 2820668 55 + 1.786 1.804 0.061
ENSG00000087266 E026 81.8160513 0.0018538466 7.930567e-01 0.945922630 4 2820669 2820753 85 + 1.899 1.935 0.120
ENSG00000087266 E027 103.4116712 0.0003506011 6.458845e-02 0.383203984 4 2822935 2823037 103 + 2.022 2.006 -0.055
ENSG00000087266 E028 4.9059830 0.0096794094 2.659522e-01 0.670743127 4 2823395 2823569 175 + 0.828 0.716 -0.451
ENSG00000087266 E029 0.3579807 0.0267409559 2.236545e-01   4 2823570 2823573 4 + 0.198 0.000 -12.863
ENSG00000087266 E030 90.1734964 0.0003593760 6.555089e-02 0.385747480 4 2824613 2824664 52 + 1.965 1.945 -0.069
ENSG00000087266 E031 100.2075561 0.0003506262 5.071310e-01 0.833254103 4 2824665 2824730 66 + 1.989 2.014 0.082
ENSG00000087266 E032 28.4725757 0.0574339577 8.135751e-02 0.420644984 4 2824731 2824750 20 + 1.329 1.574 0.845
ENSG00000087266 E033 23.2503218 0.0462176618 2.807641e-02 0.271647909 4 2824751 2824759 9 + 1.209 1.506 1.033
ENSG00000087266 E034 64.9811901 0.0765284389 4.912627e-02 0.341886722 4 2824760 2825125 366 + 1.671 1.935 0.889
ENSG00000087266 E035 89.8522721 0.0004568302 7.681330e-01 0.938963127 4 2825126 2825196 71 + 1.939 1.975 0.122
ENSG00000087266 E036 7.6594442 0.0043326564 6.645665e-01 0.902135847 4 2825197 2825220 24 + 0.882 0.973 0.342
ENSG00000087266 E037 6.7553477 0.2366563658 3.435580e-01 0.734645106 4 2826325 2826695 371 + 0.787 0.959 0.660
ENSG00000087266 E038 4.6314103 0.0059132777 3.418195e-01 0.733408005 4 2826696 2826849 154 + 0.649 0.819 0.696
ENSG00000087266 E039 32.9852458 0.0775541852 2.341851e-01 0.639101042 4 2826850 2827229 380 + 1.430 1.614 0.632
ENSG00000087266 E040 109.1393082 0.0004418822 3.991669e-02 0.313826423 4 2827230 2827318 89 + 2.051 2.028 -0.077
ENSG00000087266 E041 88.4724718 0.0005255375 4.555840e-03 0.121081583 4 2827606 2827674 69 + 1.979 1.918 -0.203
ENSG00000087266 E042 147.0202725 0.0003067412 3.348461e-04 0.028358766 4 2829493 2829796 304 + 2.193 2.136 -0.190
ENSG00000087266 E043 51.3702314 0.0013306352 5.058450e-02 0.345813565 4 2829797 2829805 9 + 1.734 1.684 -0.172
ENSG00000087266 E044 176.1052554 0.0014335093 3.891576e-05 0.007472413 4 2829806 2830147 342 + 2.284 2.204 -0.268
ENSG00000087266 E045 110.4824224 0.0018833904 2.494393e-03 0.089311208 4 2831571 2831679 109 + 2.080 2.010 -0.234
ENSG00000087266 E046 65.2152584 0.0137919572 3.471646e-01 0.737059875 4 2831923 2831978 56 + 1.828 1.811 -0.056
ENSG00000087266 E047 12.2115747 0.0670081155 5.800635e-01 0.866883192 4 2831979 2832330 352 + 1.048 1.170 0.439
ENSG00000087266 E048 70.5103575 0.0148762966 8.174526e-01 0.953729716 4 2832331 2832344 14 + 1.841 1.870 0.100
ENSG00000087266 E049 111.3697339 0.0047558375 4.131325e-01 0.782403445 4 2832345 2832412 68 + 2.045 2.054 0.033
ENSG00000087266 E050 7.8201308 0.0907638552 4.914419e-01 0.825215110 4 2832921 2832989 69 + 0.964 0.907 -0.214
ENSG00000087266 E051 121.6700776 0.0016881874 3.964215e-02 0.313050966 4 2832990 2833049 60 + 2.097 2.070 -0.092
ENSG00000087266 E052 5.5821858 0.0047091691 2.338363e-02 0.251871369 4 2833050 2833696 647 + 0.619 0.956 1.348
ENSG00000087266 E053 1493.6893316 0.0032011172 9.595947e-05 0.013218078 4 2833697 2841098 7402 + 3.116 3.228 0.372