ENSG00000083844

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000263095 ENSG00000083844 HEK293_DMSO_6hA HEK293_OSMI2_6hA ZNF264 protein_coding protein_coding 3.548376 3.230456 2.734706 0.4714684 0.35254 -0.2395452 0.8872377 0.1132777 0.5770973 0.11327774 0.09312518 2.25168726 0.27522917 0.04313333 0.2267333 0.18360000 2.660875e-01 1.621391e-10 FALSE TRUE
ENST00000536056 ENSG00000083844 HEK293_DMSO_6hA HEK293_OSMI2_6hA ZNF264 protein_coding protein_coding 3.548376 3.230456 2.734706 0.4714684 0.35254 -0.2395452 0.1344288 1.0754301 0.0000000 0.25557690 0.00000000 -6.76212303 0.04057917 0.32463333 0.0000000 -0.32463333 1.621391e-10 1.621391e-10 FALSE TRUE
ENST00000599653 ENSG00000083844 HEK293_DMSO_6hA HEK293_OSMI2_6hA ZNF264 protein_coding protein_coding 3.548376 3.230456 2.734706 0.4714684 0.35254 -0.2395452 0.3130402 0.6509545 0.6669103 0.09293108 0.11508866 0.03441363 0.10937500 0.20303333 0.2572333 0.05420000 7.959617e-01 1.621391e-10   FALSE
ENST00000600531 ENSG00000083844 HEK293_DMSO_6hA HEK293_OSMI2_6hA ZNF264 protein_coding protein_coding 3.548376 3.230456 2.734706 0.4714684 0.35254 -0.2395452 2.1928695 1.3907935 1.4906984 0.23060544 0.47308909 0.09938979 0.57030000 0.42923333 0.5160000 0.08676667 7.651873e-01 1.621391e-10   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000083844 E001 1.157751 0.182051116 2.528249e-01   19 57191500 57191500 1 + 0.414 0.282 -0.803
ENSG00000083844 E002 3.284836 0.219156983 4.261776e-01 0.789880977 19 57191501 57191522 22 + 0.694 0.605 -0.378
ENSG00000083844 E003 3.942296 0.144098595 4.032190e-01 0.775685718 19 57191523 57191527 5 + 0.729 0.692 -0.152
ENSG00000083844 E004 7.992518 0.152723355 1.532900e-01 0.543895179 19 57191528 57191536 9 + 1.034 0.897 -0.512
ENSG00000083844 E005 13.092601 0.031668461 1.312828e-03 0.063240542 19 57191537 57191698 162 + 1.247 1.063 -0.656
ENSG00000083844 E006 7.468820 0.066137728 2.057949e-03 0.080868073 19 57191699 57191774 76 + 1.063 0.768 -1.119
ENSG00000083844 E007 4.292519 0.006501535 3.427872e-05 0.006888883 19 57191775 57191790 16 + 0.902 0.494 -1.719
ENSG00000083844 E008 10.273648 0.048952728 2.154215e-03 0.082738249 19 57191791 57191873 83 + 1.162 0.934 -0.831
ENSG00000083844 E009 12.035421 0.037045664 4.313420e-02 0.324010209 19 57191874 57191946 73 + 1.142 1.088 -0.195
ENSG00000083844 E010 21.131574 0.011841170 2.285949e-02 0.249439330 19 57193875 57194001 127 + 1.340 1.347 0.024
ENSG00000083844 E011 7.990330 0.003198383 8.890134e-01 0.973485211 19 57194002 57194169 168 + 0.823 1.028 0.776
ENSG00000083844 E012 11.891536 0.002413390 4.708347e-01 0.814214176 19 57194769 57194969 201 + 1.027 1.155 0.464
ENSG00000083844 E013 5.537227 0.005108460 7.799386e-01 0.942247645 19 57205397 57205492 96 + 0.669 0.884 0.861
ENSG00000083844 E014 308.309150 0.070668444 4.953722e-03 0.126296667 19 57211354 57222846 11493 + 2.292 2.599 1.024