ENSG00000081791

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000194118 ENSG00000081791 HEK293_DMSO_6hA HEK293_OSMI2_6hA DELE1 protein_coding protein_coding 36.72436 40.09983 44.92296 0.5293154 0.2843023 0.1638181 3.509839 2.857171 4.723415 0.5973107 0.6570844 0.7232536 0.09342083 0.07166667 0.10506667 0.03340000 0.614665952 0.003936662 FALSE  
ENST00000432126 ENSG00000081791 HEK293_DMSO_6hA HEK293_OSMI2_6hA DELE1 protein_coding protein_coding 36.72436 40.09983 44.92296 0.5293154 0.2843023 0.1638181 4.433970 6.711358 5.063467 0.4880392 0.3445046 -0.4057808 0.12015417 0.16713333 0.11270000 -0.05443333 0.148924475 0.003936662 FALSE  
ENST00000502729 ENSG00000081791 HEK293_DMSO_6hA HEK293_OSMI2_6hA DELE1 protein_coding retained_intron 36.72436 40.09983 44.92296 0.5293154 0.2843023 0.1638181 5.916335 7.635040 6.805954 0.3861438 0.6987725 -0.1656083 0.16132500 0.19036667 0.15153333 -0.03883333 0.497686584 0.003936662 FALSE  
ENST00000506775 ENSG00000081791 HEK293_DMSO_6hA HEK293_OSMI2_6hA DELE1 protein_coding processed_transcript 36.72436 40.09983 44.92296 0.5293154 0.2843023 0.1638181 3.865522 4.882050 3.205614 0.7632974 0.4112899 -0.6053449 0.10730833 0.12130000 0.07136667 -0.04993333 0.259603503 0.003936662    
ENST00000508751 ENSG00000081791 HEK293_DMSO_6hA HEK293_OSMI2_6hA DELE1 protein_coding protein_coding 36.72436 40.09983 44.92296 0.5293154 0.2843023 0.1638181 7.115019 6.049329 10.853706 0.2952529 0.5075405 0.8422864 0.19250417 0.15106667 0.24156667 0.09050000 0.003936662 0.003936662 FALSE  
ENST00000509110 ENSG00000081791 HEK293_DMSO_6hA HEK293_OSMI2_6hA DELE1 protein_coding retained_intron 36.72436 40.09983 44.92296 0.5293154 0.2843023 0.1638181 2.213447 3.399042 2.330694 0.3222406 0.9794556 -0.5424302 0.06031667 0.08460000 0.05200000 -0.03260000 0.497222431 0.003936662    
MSTRG.27079.7 ENSG00000081791 HEK293_DMSO_6hA HEK293_OSMI2_6hA DELE1 protein_coding   36.72436 40.09983 44.92296 0.5293154 0.2843023 0.1638181 7.757263 6.454819 9.387269 0.5179758 0.7846262 0.5396316 0.21433750 0.16110000 0.20893333 0.04783333 0.423294366 0.003936662 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000081791 E001 0.0000000       5 141923084 141923101 18 +      
ENSG00000081791 E002 0.0000000       5 141923102 141923104 3 +      
ENSG00000081791 E003 0.0000000       5 141923105 141923110 6 +      
ENSG00000081791 E004 0.0000000       5 141923111 141923435 325 +      
ENSG00000081791 E005 0.1544607 0.0359403045 4.610602e-01   5 141923436 141923626 191 + 0.000 0.125 9.762
ENSG00000081791 E006 0.3262289 0.0252704663 1.840511e-01   5 141923627 141923744 118 + 0.000 0.221 13.132
ENSG00000081791 E007 39.7266397 0.0026349151 3.668182e-01 0.751403775 5 141923745 141923854 110 + 1.628 1.587 -0.140
ENSG00000081791 E008 65.5579884 0.0004670900 4.358682e-02 0.325288323 5 141923855 141923870 16 + 1.854 1.780 -0.251
ENSG00000081791 E009 130.3154979 0.0002382585 1.816253e-03 0.075810955 5 141923871 141923909 39 + 2.154 2.071 -0.278
ENSG00000081791 E010 193.7494819 0.0001793793 9.852277e-05 0.013433134 5 141923910 141923972 63 + 2.324 2.239 -0.285
ENSG00000081791 E011 297.3633452 0.0001592431 1.597811e-02 0.214702939 5 141924581 141924695 115 + 2.486 2.450 -0.119
ENSG00000081791 E012 313.1841207 0.0001637449 8.326199e-03 0.159174714 5 141925410 141925527 118 + 2.512 2.473 -0.130
ENSG00000081791 E013 299.1031800 0.0003108695 2.601852e-03 0.091442252 5 141928151 141928298 148 + 2.500 2.449 -0.169
ENSG00000081791 E014 342.9217310 0.0004749713 5.141252e-04 0.036690427 5 141929582 141929740 159 + 2.563 2.504 -0.198
ENSG00000081791 E015 243.2371420 0.0003033147 7.484797e-03 0.152183829 5 141929989 141930074 86 + 2.406 2.358 -0.162
ENSG00000081791 E016 195.0854997 0.0058340609 3.019281e-01 0.701430562 5 141930178 141930246 69 + 2.306 2.276 -0.100
ENSG00000081791 E017 151.6065554 0.0058823540 4.104279e-01 0.780665740 5 141930247 141930274 28 + 2.192 2.171 -0.068
ENSG00000081791 E018 14.3693000 0.1039696246 2.245828e-02 0.247625748 5 141931219 141931280 62 + 0.961 1.327 1.314
ENSG00000081791 E019 294.5276646 0.0014870875 4.373361e-01 0.796008645 5 141933259 141933401 143 + 2.470 2.463 -0.022
ENSG00000081791 E020 67.3521769 0.0321442805 3.227103e-02 0.288389150 5 141933402 141933882 481 + 1.718 1.920 0.682
ENSG00000081791 E021 132.2322489 0.0024508520 4.561628e-01 0.806720243 5 141934240 141934257 18 + 2.128 2.114 -0.046
ENSG00000081791 E022 283.8733817 0.0007161780 7.878228e-02 0.414972411 5 141934258 141934398 141 + 2.463 2.435 -0.092
ENSG00000081791 E023 257.6393043 0.0001740658 5.804837e-01 0.867112362 5 141934494 141934586 93 + 2.393 2.419 0.087
ENSG00000081791 E024 99.5717119 0.0189743380 7.868780e-02 0.414946429 5 141934587 141934996 410 + 1.930 2.057 0.424
ENSG00000081791 E025 21.9961100 0.2394902535 6.686996e-02 0.388710127 5 141937074 141937197 124 + 1.185 1.480 1.030
ENSG00000081791 E026 274.8899241 0.0001337307 8.942070e-01 0.974657425 5 141937198 141937357 160 + 2.427 2.444 0.055
ENSG00000081791 E027 405.3961245 0.0002186351 1.518237e-01 0.541906473 5 141938521 141938760 240 + 2.610 2.598 -0.040
ENSG00000081791 E028 103.7950147 0.0092139571 4.780344e-01 0.818239715 5 141938761 141938851 91 + 1.992 2.038 0.153
ENSG00000081791 E029 56.5800733 0.0076045245 4.612170e-01 0.809213703 5 141938852 141938855 4 + 1.724 1.778 0.181
ENSG00000081791 E030 88.9100418 0.0066082634 5.625360e-01 0.859016570 5 141938856 141938904 49 + 1.930 1.967 0.124
ENSG00000081791 E031 257.2691164 0.0126468358 2.569308e-03 0.090819468 5 141938905 141939505 601 + 2.315 2.487 0.571
ENSG00000081791 E032 92.4013741 0.0003823204 7.879600e-04 0.047121026 5 141939506 141939509 4 + 1.891 2.028 0.461
ENSG00000081791 E033 153.8187783 0.0002253527 9.965842e-05 0.013525223 5 141939510 141939553 44 + 2.117 2.242 0.417
ENSG00000081791 E034 780.4335958 0.0005530378 6.132119e-06 0.002148836 5 141939554 141942047 2494 + 2.847 2.929 0.272
ENSG00000081791 E035 5.8403987 0.0041897816 8.560683e-01 0.964500079 5 141949332 141949410 79 + 0.809 0.844 0.137
ENSG00000081791 E036 2.9103666 0.0826272076 7.264967e-01 0.924497601 5 141951426 141951573 148 + 0.606 0.565 -0.183