ENSG00000081189

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000340208 ENSG00000081189 HEK293_DMSO_6hA HEK293_OSMI2_6hA MEF2C protein_coding protein_coding 2.795248 1.058591 1.03428 0.4464625 0.2560815 -0.03320204 0.044524466 0.00000000 0.09021098 0.00000000 0.04520669 3.324969 0.027562500 0.00000000 0.06993333 0.06993333 0.275657799 0.009593136 FALSE TRUE
ENST00000424173 ENSG00000081189 HEK293_DMSO_6hA HEK293_OSMI2_6hA MEF2C protein_coding protein_coding 2.795248 1.058591 1.03428 0.4464625 0.2560815 -0.03320204 0.165554725 0.02970864 0.00000000 0.02970864 0.00000000 -1.989453 0.081629167 0.05830000 0.00000000 -0.05830000 0.767956355 0.009593136 FALSE TRUE
ENST00000503955 ENSG00000081189 HEK293_DMSO_6hA HEK293_OSMI2_6hA MEF2C protein_coding retained_intron 2.795248 1.058591 1.03428 0.4464625 0.2560815 -0.03320204 0.148476053 0.51771803 0.07345043 0.36969517 0.07345043 -2.660776 0.083366667 0.35886667 0.14010000 -0.21876667 0.671575532 0.009593136   FALSE
ENST00000508569 ENSG00000081189 HEK293_DMSO_6hA HEK293_OSMI2_6hA MEF2C protein_coding protein_coding 2.795248 1.058591 1.03428 0.4464625 0.2560815 -0.03320204 0.226759076 0.00000000 0.00000000 0.00000000 0.00000000 0.000000 0.054804167 0.00000000 0.00000000 0.00000000   0.009593136 FALSE TRUE
ENST00000510942 ENSG00000081189 HEK293_DMSO_6hA HEK293_OSMI2_6hA MEF2C protein_coding protein_coding 2.795248 1.058591 1.03428 0.4464625 0.2560815 -0.03320204 0.238597538 0.06284344 0.22220849 0.06284344 0.16636499 1.672550 0.105375000 0.12333333 0.22173333 0.09840000 0.741321224 0.009593136 FALSE TRUE
ENST00000513252 ENSG00000081189 HEK293_DMSO_6hA HEK293_OSMI2_6hA MEF2C protein_coding protein_coding 2.795248 1.058591 1.03428 0.4464625 0.2560815 -0.03320204 0.005268189 0.04214551 0.00000000 0.04214551 0.00000000 -2.382543 0.007283333 0.05826667 0.00000000 -0.05826667 0.756167205 0.009593136 FALSE FALSE
ENST00000627717 ENSG00000081189 HEK293_DMSO_6hA HEK293_OSMI2_6hA MEF2C protein_coding protein_coding 2.795248 1.058591 1.03428 0.4464625 0.2560815 -0.03320204 0.176837975 0.05154606 0.00000000 0.05154606 0.00000000 -2.621666 0.050325000 0.02653333 0.00000000 -0.02653333 0.732963623 0.009593136 FALSE TRUE
ENST00000636998 ENSG00000081189 HEK293_DMSO_6hA HEK293_OSMI2_6hA MEF2C protein_coding protein_coding 2.795248 1.058591 1.03428 0.4464625 0.2560815 -0.03320204 0.280780649 0.20760994 0.00000000 0.07160018 0.00000000 -4.443673 0.110429167 0.20713333 0.00000000 -0.20713333 0.009593136 0.009593136 FALSE TRUE
ENST00000637481 ENSG00000081189 HEK293_DMSO_6hA HEK293_OSMI2_6hA MEF2C protein_coding protein_coding 2.795248 1.058591 1.03428 0.4464625 0.2560815 -0.03320204 0.488218438 0.13794497 0.34428283 0.02931520 0.10675566 1.259841 0.180516667 0.15700000 0.31703333 0.16003333 0.405370473 0.009593136 FALSE TRUE
MSTRG.26568.10 ENSG00000081189 HEK293_DMSO_6hA HEK293_OSMI2_6hA MEF2C protein_coding   2.795248 1.058591 1.03428 0.4464625 0.2560815 -0.03320204 0.345933874 0.00000000 0.23164516 0.00000000 0.23164516 4.594818 0.104604167 0.00000000 0.17423333 0.17423333 0.753993873 0.009593136 FALSE TRUE
MSTRG.26568.23 ENSG00000081189 HEK293_DMSO_6hA HEK293_OSMI2_6hA MEF2C protein_coding   2.795248 1.058591 1.03428 0.4464625 0.2560815 -0.03320204 0.409714929 0.00000000 0.00000000 0.00000000 0.00000000 0.000000 0.097100000 0.00000000 0.00000000 0.00000000   0.009593136 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000081189 E001 0.0000000       5 88717117 88718240 1124 -      
ENSG00000081189 E002 0.1812101 0.035470041 0.716136512   5 88718241 88718273 33 - 0.095 0.000 -9.069
ENSG00000081189 E003 24.2839824 0.001518552 0.007650544 0.15389220 5 88718274 88720025 1752 - 1.327 1.503 0.608
ENSG00000081189 E004 4.4010217 0.005590884 0.337091853 0.72972715 5 88720026 88720336 311 - 0.669 0.802 0.545
ENSG00000081189 E005 4.3098017 0.005647192 0.269756731 0.67418797 5 88720337 88720824 488 - 0.645 0.803 0.645
ENSG00000081189 E006 0.5253094 0.892194685 0.950164863   5 88720825 88720828 4 - 0.184 0.150 -0.347
ENSG00000081189 E007 1.6510666 0.028417081 0.177500155 0.57610023 5 88720829 88720843 15 - 0.297 0.540 1.331
ENSG00000081189 E008 1.7043315 0.010964824 0.597197873 0.87445616 5 88720844 88720855 12 - 0.392 0.485 0.489
ENSG00000081189 E009 18.8145920 0.002312462 0.879782263 0.97111614 5 88720856 88721569 714 - 1.301 1.290 -0.037
ENSG00000081189 E010 1.5340522 0.016838072 0.248561984   5 88721570 88721576 7 - 0.470 0.261 -1.246
ENSG00000081189 E011 1.4653587 0.014603201 0.248834660   5 88721577 88721619 43 - 0.469 0.261 -1.243
ENSG00000081189 E012 1.6465688 0.013213413 0.176439872 0.57479134 5 88721620 88721646 27 - 0.504 0.261 -1.415
ENSG00000081189 E013 5.7824233 0.186310176 0.636286703 0.89078633 5 88721647 88721924 278 - 0.862 0.744 -0.465
ENSG00000081189 E014 12.7859150 0.003088610 0.993364671 0.99838225 5 88721925 88722488 564 - 1.136 1.138 0.005
ENSG00000081189 E015 2.3376929 0.153175588 0.738516042 0.92851760 5 88722489 88722494 6 - 0.474 0.583 0.518
ENSG00000081189 E016 2.0020221 0.087281320 0.657385406 0.89962930 5 88722495 88722497 3 - 0.433 0.537 0.513
ENSG00000081189 E017 4.1114073 0.110385383 0.232186940 0.63720091 5 88722498 88722566 69 - 0.570 0.849 1.157
ENSG00000081189 E018 3.5305970 0.007950719 0.004522302 0.12061582 5 88722567 88722600 34 - 0.433 0.855 1.850
ENSG00000081189 E019 2.9589041 0.014020809 0.008686957 0.16254595 5 88722601 88722603 3 - 0.391 0.802 1.870
ENSG00000081189 E020 5.5237429 0.004874470 0.130783030 0.51148014 5 88722604 88722729 126 - 0.732 0.924 0.753
ENSG00000081189 E021 6.6683507 0.004045779 0.894492077 0.97475424 5 88722730 88722827 98 - 0.893 0.880 -0.052
ENSG00000081189 E022 3.3665096 0.010723223 0.593611824 0.87280265 5 88722828 88722829 2 - 0.668 0.589 -0.344
ENSG00000081189 E023 1.2375233 0.013358470 0.118765591   5 88722830 88722836 7 - 0.433 0.150 -2.056
ENSG00000081189 E024 1.2375233 0.013358470 0.118765591   5 88722837 88722852 16 - 0.433 0.150 -2.056
ENSG00000081189 E025 1.0607528 0.015378759 0.183276229   5 88722853 88722865 13 - 0.392 0.150 -1.832
ENSG00000081189 E026 2.4432949 0.008127245 0.300726874 0.70049339 5 88722866 88722925 60 - 0.594 0.422 -0.832
ENSG00000081189 E027 8.1732362 0.003302046 0.143680450 0.53055017 5 88728493 88728628 136 - 1.022 0.856 -0.624
ENSG00000081189 E028 5.8133818 0.005249456 0.130839151 0.51150972 5 88729218 88729347 130 - 0.906 0.709 -0.779
ENSG00000081189 E029 0.0000000       5 88729348 88729519 172 -      
ENSG00000081189 E030 0.1795728 0.040667792 0.316988245   5 88730211 88730234 24 - 0.000 0.150 12.017
ENSG00000081189 E031 0.0000000       5 88731437 88731728 292 -      
ENSG00000081189 E032 3.3969236 0.007255034 0.110740721 0.47697795 5 88731729 88731804 76 - 0.731 0.485 -1.093
ENSG00000081189 E033 3.2429716 0.007014498 0.956975848 0.99013181 5 88731805 88731851 47 - 0.621 0.632 0.051
ENSG00000081189 E034 4.2582640 0.005466278 0.961881087 0.99120899 5 88731852 88731901 50 - 0.712 0.709 -0.015
ENSG00000081189 E035 0.0000000       5 88732472 88732543 72 -      
ENSG00000081189 E036 2.9189821 0.007462734 0.668553884 0.90364298 5 88749070 88749085 16 - 0.566 0.632 0.294
ENSG00000081189 E037 2.2289296 0.042147734 0.670103870 0.90420124 5 88749086 88749117 32 - 0.470 0.541 0.345
ENSG00000081189 E038 0.0000000       5 88749118 88749124 7 -      
ENSG00000081189 E039 1.4713454 0.021053703 0.666397559   5 88751857 88751861 5 - 0.347 0.423 0.430
ENSG00000081189 E040 1.1776187 0.026062310 0.300805411   5 88751862 88751865 4 - 0.239 0.423 1.167
ENSG00000081189 E041 4.8065755 0.004834404 0.558391794 0.85740465 5 88751866 88752043 178 - 0.787 0.709 -0.318
ENSG00000081189 E042 0.0000000       5 88760988 88761022 35 -      
ENSG00000081189 E043 0.1717682 0.053951042 0.318233703   5 88761023 88761125 103 - 0.000 0.150 11.994
ENSG00000081189 E044 3.0576459 0.007574528 0.095495729 0.44917689 5 88761185 88761199 15 - 0.691 0.422 -1.249
ENSG00000081189 E045 2.6283424 0.009162869 0.002482137 0.08909536 5 88761200 88761208 9 - 0.691 0.150 -3.251
ENSG00000081189 E046 2.4033092 0.042522367 0.007959806 0.15590910 5 88761209 88761216 8 - 0.650 0.149 -3.077
ENSG00000081189 E047 3.6544510 0.011782639 0.252235571 0.65805523 5 88761217 88761268 52 - 0.713 0.540 -0.755
ENSG00000081189 E048 3.6295806 0.006515140 0.200522677 0.60404312 5 88761269 88761309 41 - 0.732 0.540 -0.832
ENSG00000081189 E049 2.2087371 0.067239425 0.440625781 0.79808222 5 88761310 88761324 15 - 0.585 0.422 -0.793
ENSG00000081189 E050 2.2137395 0.013575145 0.119629157 0.49292877 5 88761325 88761328 4 - 0.618 0.349 -1.355
ENSG00000081189 E051 0.0000000       5 88761718 88761912 195 -      
ENSG00000081189 E052 0.0000000       5 88771779 88771788 10 -      
ENSG00000081189 E053 0.0000000       5 88771789 88771866 78 -      
ENSG00000081189 E054 0.0000000       5 88771973 88772000 28 -      
ENSG00000081189 E055 0.0000000       5 88772266 88772281 16 -      
ENSG00000081189 E056 0.0000000       5 88772282 88772361 80 -      
ENSG00000081189 E057 0.0000000       5 88785339 88785542 204 -      
ENSG00000081189 E058 0.0000000       5 88804526 88804597 72 -      
ENSG00000081189 E059 5.6090179 0.004265491 0.040527422 0.31591677 5 88804598 88804753 156 - 0.907 0.632 -1.106
ENSG00000081189 E060 1.8949835 0.010352781 0.763343217 0.93704648 5 88804754 88804769 16 - 0.471 0.422 -0.250
ENSG00000081189 E061 3.3850398 0.006200943 0.921734572 0.98125136 5 88804770 88804801 32 - 0.645 0.632 -0.055
ENSG00000081189 E062 0.0000000       5 88817805 88817831 27 -      
ENSG00000081189 E063 3.7802039 0.006090324 0.785113756 0.94372352 5 88823735 88823795 61 - 0.668 0.709 0.170
ENSG00000081189 E064 4.2661297 0.005916562 0.729579180 0.92543487 5 88823796 88823860 65 - 0.691 0.742 0.211
ENSG00000081189 E065 2.7727082 0.032020043 0.791941057 0.94565871 5 88823861 88823862 2 - 0.539 0.589 0.227
ENSG00000081189 E066 5.2046902 0.004467864 0.652453955 0.89749384 5 88823863 88823900 38 - 0.769 0.830 0.239
ENSG00000081189 E067 4.3521386 0.013061007 0.661408238 0.90099775 5 88823901 88823927 27 - 0.710 0.774 0.260
ENSG00000081189 E068 1.3680979 0.016400259 0.272610952   5 88823928 88823930 3 - 0.295 0.485 1.078
ENSG00000081189 E069 0.0000000       5 88823931 88824275 345 -      
ENSG00000081189 E070 0.0000000       5 88824278 88824309 32 -      
ENSG00000081189 E071 0.0000000       5 88824310 88824340 31 -      
ENSG00000081189 E072 0.0000000       5 88824880 88824914 35 -      
ENSG00000081189 E073 0.0000000       5 88825719 88825864 146 -      
ENSG00000081189 E074 0.0000000       5 88827036 88827192 157 -      
ENSG00000081189 E075 0.0000000       5 88839240 88839378 139 -      
ENSG00000081189 E076 0.0000000       5 88839379 88839623 245 -      
ENSG00000081189 E077 0.0000000       5 88877938 88877941 4 -      
ENSG00000081189 E078 0.0000000       5 88877942 88877962 21 -      
ENSG00000081189 E079 0.0000000       5 88877963 88878020 58 -      
ENSG00000081189 E080 0.0000000       5 88880844 88880923 80 -      
ENSG00000081189 E081 0.1767706 0.339803357 0.712897408   5 88880924 88880981 58 - 0.097 0.000 -11.605
ENSG00000081189 E082 0.0000000       5 88880982 88881022 41 -      
ENSG00000081189 E083 0.0000000       5 88881023 88881264 242 -      
ENSG00000081189 E084 3.5331026 0.027568825 0.394218011 0.76949516 5 88882955 88882959 5 - 0.615 0.743 0.536
ENSG00000081189 E085 4.3395123 0.071564310 0.671391242 0.90472231 5 88882960 88882999 40 - 0.715 0.775 0.241
ENSG00000081189 E086 2.5246226 0.008097056 0.496582490 0.82755848 5 88883000 88883048 49 - 0.594 0.485 -0.508
ENSG00000081189 E087 3.5210313 0.006441264 0.861578749 0.96622392 5 88883049 88883466 418 - 0.645 0.672 0.117
ENSG00000081189 E088 0.4979971 0.062953539 0.037268100   5 88883652 88883747 96 - 0.000 0.349 13.350
ENSG00000081189 E089 0.0000000       5 88884328 88884355 28 -      
ENSG00000081189 E090 0.0000000       5 88884356 88884426 71 -      
ENSG00000081189 E091 0.0000000       5 88884489 88884568 80 -      
ENSG00000081189 E092 0.0000000       5 88887392 88887501 110 -      
ENSG00000081189 E093 0.0000000       5 88887502 88887542 41 -      
ENSG00000081189 E094 0.0000000       5 88887543 88887564 22 -      
ENSG00000081189 E095 0.0000000       5 88887565 88887584 20 -      
ENSG00000081189 E096 0.0000000       5 88887585 88887598 14 -      
ENSG00000081189 E097 0.0000000       5 88888167 88888232 66 -      
ENSG00000081189 E098 0.0000000       5 88888879 88888888 10 -      
ENSG00000081189 E099 0.0000000       5 88888889 88889050 162 -      
ENSG00000081189 E100 0.0000000       5 88889051 88889324 274 -      
ENSG00000081189 E101 0.0000000       5 88903916 88904257 342 -