ENSG00000078668

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000022615 ENSG00000078668 HEK293_DMSO_6hA HEK293_OSMI2_6hA VDAC3 protein_coding protein_coding 134.9501 71.3631 47.30742 17.22232 6.808347 -0.593009 116.35440 62.694995 40.703736 15.4829500 6.1868744 -0.6230648 0.86825000 0.8740 0.85813333 -0.01586667 0.74796145 0.03641687 FALSE  
MSTRG.31451.4 ENSG00000078668 HEK293_DMSO_6hA HEK293_OSMI2_6hA VDAC3 protein_coding   134.9501 71.3631 47.30742 17.22232 6.808347 -0.593009 11.83927 2.409458 4.157935 0.8750085 0.8315065 0.7846488 0.07827917 0.0336 0.08663333 0.05303333 0.03641687 0.03641687 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000078668 E001 0.1125166 3.312076e-02 0.3062704262   8 42391624 42391642 19 + 0.148 0.000 -9.239
ENSG00000078668 E002 0.4214379 7.446384e-02 0.9049418365   8 42391643 42391666 24 + 0.147 0.174 0.289
ENSG00000078668 E003 1.8409218 1.483014e-02 0.7974510610 0.94743089 8 42391667 42391749 83 + 0.481 0.436 -0.229
ENSG00000078668 E004 4.2874091 4.174235e-02 0.1504791246 0.54010539 8 42391750 42391841 92 + 0.867 0.624 -0.987
ENSG00000078668 E005 4.1031583 3.811233e-02 0.4239305339 0.78862764 8 42391842 42391845 4 + 0.792 0.650 -0.581
ENSG00000078668 E006 6.0553740 4.469473e-02 0.3054184918 0.70425609 8 42391846 42391855 10 + 0.949 0.775 -0.671
ENSG00000078668 E007 8.9662738 1.067871e-02 0.0185383229 0.22882961 8 42391856 42391863 8 + 1.144 0.872 -1.004
ENSG00000078668 E008 28.9282763 1.033720e-03 0.0003896909 0.03094231 8 42391864 42391879 16 + 1.593 1.367 -0.777
ENSG00000078668 E009 43.9827607 1.955542e-03 0.0083698036 0.15956455 8 42391880 42391886 7 + 1.727 1.581 -0.495
ENSG00000078668 E010 47.2281451 8.640894e-04 0.0108159957 0.17997150 8 42391887 42391889 3 + 1.747 1.616 -0.442
ENSG00000078668 E011 88.2531162 3.629751e-04 0.0696315795 0.39481162 8 42391890 42391901 12 + 1.977 1.909 -0.226
ENSG00000078668 E012 88.2120954 3.585781e-04 0.0927951125 0.44345847 8 42391902 42391902 1 + 1.973 1.911 -0.209
ENSG00000078668 E013 138.5917998 4.000394e-04 0.2276654557 0.63273539 8 42391903 42391928 26 + 2.151 2.115 -0.119
ENSG00000078668 E014 1.7948627 2.538778e-02 0.9203842831 0.98089616 8 42393811 42393844 34 + 0.419 0.437 0.097
ENSG00000078668 E015 221.8209694 2.374031e-04 0.9971668957 0.99932021 8 42393845 42393884 40 + 2.327 2.329 0.008
ENSG00000078668 E016 258.8956583 1.449491e-04 0.4066518199 0.77799303 8 42394210 42394242 33 + 2.405 2.388 -0.056
ENSG00000078668 E017 293.4950056 1.457639e-04 0.1122355279 0.47963785 8 42394243 42394278 36 + 2.425 2.460 0.119
ENSG00000078668 E018 314.9919246 1.296036e-04 0.5407301921 0.85024923 8 42395084 42395133 50 + 2.470 2.484 0.048
ENSG00000078668 E019 2.0102732 3.449522e-01 0.5461769436 0.85248361 8 42396656 42396677 22 + 0.349 0.512 0.870
ENSG00000078668 E020 4.4327450 2.715119e-01 0.2777958483 0.68115047 8 42396678 42396680 3 + 0.549 0.780 0.982
ENSG00000078668 E021 7.0173201 1.284243e-01 0.1395283789 0.52447845 8 42396681 42397599 919 + 0.696 0.971 1.073
ENSG00000078668 E022 564.5656820 4.733310e-04 0.5371329572 0.84845136 8 42398712 42398864 153 + 2.725 2.738 0.043
ENSG00000078668 E023 1.7203230 2.447422e-01 0.6315762648 0.88868589 8 42399550 42399650 101 + 0.499 0.349 -0.805
ENSG00000078668 E024 344.3524063 7.510319e-04 0.8244528530 0.95560801 8 42399651 42399703 53 + 2.521 2.518 -0.010
ENSG00000078668 E025 348.7971491 3.006465e-04 0.2573616761 0.66305683 8 42401788 42401836 49 + 2.539 2.518 -0.071
ENSG00000078668 E026 449.9974652 9.986846e-05 0.0433120573 0.32449808 8 42401837 42402015 179 + 2.656 2.624 -0.107
ENSG00000078668 E027 7.4984459 3.612153e-03 0.0294132335 0.27714517 8 42402016 42402164 149 + 0.705 0.985 1.090
ENSG00000078668 E028 17.2659244 1.120981e-01 0.2023517322 0.60611517 8 42403032 42403310 279 + 1.091 1.306 0.764
ENSG00000078668 E029 509.8537355 1.042348e-04 0.8198388330 0.95450587 8 42403311 42403461 151 + 2.686 2.691 0.018
ENSG00000078668 E030 370.1383654 1.620114e-04 0.1213929529 0.49614991 8 42404867 42404924 58 + 2.529 2.560 0.105
ENSG00000078668 E031 257.1463228 3.464629e-04 0.1275487004 0.50649335 8 42405371 42405373 3 + 2.365 2.403 0.128
ENSG00000078668 E032 420.5052288 7.538346e-04 0.4759076473 0.81718233 8 42405374 42405432 59 + 2.592 2.609 0.057
ENSG00000078668 E033 868.3882421 3.950883e-04 0.1589637696 0.55271242 8 42405433 42405937 505 + 2.904 2.926 0.071