ENSG00000078304

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000328724 ENSG00000078304 HEK293_DMSO_6hA HEK293_OSMI2_6hA PPP2R5C protein_coding protein_coding 55.43219 26.95644 29.24838 6.490783 4.229552 0.1176849 4.099028 1.4478539 2.7373822 0.4751653 0.6203365 0.9142115 0.07410833 0.05166667 0.09163333 0.039966667 2.565464e-01 6.420913e-06 FALSE TRUE
ENST00000350249 ENSG00000078304 HEK293_DMSO_6hA HEK293_OSMI2_6hA PPP2R5C protein_coding protein_coding 55.43219 26.95644 29.24838 6.490783 4.229552 0.1176849 4.186621 2.2126341 0.6601186 0.4533473 0.1417057 -1.7297822 0.06560417 0.08336667 0.02203333 -0.061333333 6.420913e-06 6.420913e-06 FALSE TRUE
ENST00000445439 ENSG00000078304 HEK293_DMSO_6hA HEK293_OSMI2_6hA PPP2R5C protein_coding protein_coding 55.43219 26.95644 29.24838 6.490783 4.229552 0.1176849 21.033862 7.2457539 10.4698224 2.1707039 1.9776589 0.5304168 0.36540000 0.26220000 0.35463333 0.092433333 2.353591e-01 6.420913e-06 FALSE TRUE
ENST00000553730 ENSG00000078304 HEK293_DMSO_6hA HEK293_OSMI2_6hA PPP2R5C protein_coding retained_intron 55.43219 26.95644 29.24838 6.490783 4.229552 0.1176849 3.518477 2.3260416 1.9667686 0.9605562 0.5187593 -0.2409219 0.06197083 0.08006667 0.07690000 -0.003166667 8.778525e-01 6.420913e-06 FALSE TRUE
ENST00000556260 ENSG00000078304 HEK293_DMSO_6hA HEK293_OSMI2_6hA PPP2R5C protein_coding protein_coding 55.43219 26.95644 29.24838 6.490783 4.229552 0.1176849 7.519787 5.6268350 5.1494399 0.5210551 0.5545579 -0.1276709 0.15973750 0.22403333 0.17980000 -0.044233333 7.410144e-01 6.420913e-06   FALSE
ENST00000694906 ENSG00000078304 HEK293_DMSO_6hA HEK293_OSMI2_6hA PPP2R5C protein_coding protein_coding 55.43219 26.95644 29.24838 6.490783 4.229552 0.1176849 3.606689 0.9477941 1.6769608 0.4741595 0.1089861 0.8166390 0.05952083 0.03586667 0.05896667 0.023100000 7.360650e-01 6.420913e-06 FALSE TRUE
MSTRG.10194.19 ENSG00000078304 HEK293_DMSO_6hA HEK293_OSMI2_6hA PPP2R5C protein_coding   55.43219 26.95644 29.24838 6.490783 4.229552 0.1176849 4.651438 1.3819707 2.2658333 0.6752995 1.2672267 0.7092660 0.07672500 0.04660000 0.06786667 0.021266667 9.860869e-01 6.420913e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000078304 E001 2.5456232 0.3613884839 0.509768414 0.83460834 14 101761709 101761797 89 + 0.418 0.637 1.045
ENSG00000078304 E002 1.8389163 0.0442516652 0.430658182 0.79227518 14 101761798 101761841 44 + 0.494 0.370 -0.654
ENSG00000078304 E003 4.3577039 0.0293074848 0.209471542 0.61366974 14 101761842 101761861 20 + 0.820 0.641 -0.734
ENSG00000078304 E004 6.8851506 0.0845419227 0.097299459 0.45246156 14 101761862 101761869 8 + 1.025 0.731 -1.131
ENSG00000078304 E005 12.8936211 0.0125722848 0.002954560 0.09762657 14 101761870 101761884 15 + 1.273 0.974 -1.076
ENSG00000078304 E006 27.6956389 0.0193987407 0.035365953 0.29842219 14 101761885 101761920 36 + 1.543 1.360 -0.631
ENSG00000078304 E007 38.2919666 0.0153216636 0.030864849 0.28274550 14 101762905 101762927 23 + 1.668 1.513 -0.531
ENSG00000078304 E008 56.0183808 0.0044370431 0.043982478 0.32644100 14 101762928 101762970 43 + 1.805 1.714 -0.307
ENSG00000078304 E009 60.4848473 0.0232323447 0.212630913 0.61722412 14 101765154 101765291 138 + 1.723 1.845 0.411
ENSG00000078304 E010 47.8211407 0.0250520284 0.150523582 0.54011100 14 101765292 101765386 95 + 1.609 1.755 0.493
ENSG00000078304 E011 40.3422300 0.0514842251 0.220097031 0.62464025 14 101765387 101765448 62 + 1.530 1.686 0.533
ENSG00000078304 E012 147.9347250 0.0456346649 0.267398705 0.67185877 14 101765449 101766124 676 + 2.100 2.235 0.450
ENSG00000078304 E013 135.9460326 0.0448980570 0.227477305 0.63249890 14 101766125 101766616 492 + 2.057 2.202 0.487
ENSG00000078304 E014 31.5035020 0.0354487853 0.153975107 0.54484138 14 101766617 101767049 433 + 1.415 1.585 0.585
ENSG00000078304 E015 30.4923247 0.0203847405 0.007848799 0.15531606 14 101786018 101786110 93 + 1.611 1.371 -0.823
ENSG00000078304 E016 20.8294237 0.0078949851 0.080232361 0.41808882 14 101786111 101786120 10 + 1.411 1.283 -0.448
ENSG00000078304 E017 31.8242298 0.0024036195 0.002822328 0.09544685 14 101786121 101786183 63 + 1.596 1.425 -0.586
ENSG00000078304 E018 0.1717682 0.0421119277 0.459823266   14 101789681 101789896 216 + 0.000 0.126 10.322
ENSG00000078304 E019 4.1107822 0.0200081212 0.351317435 0.74048397 14 101797211 101797701 491 + 0.630 0.782 0.629
ENSG00000078304 E020 1.9615675 0.0703307372 0.250125936 0.65587655 14 101809803 101809833 31 + 0.340 0.569 1.185
ENSG00000078304 E021 1.9615675 0.0703307372 0.250125936 0.65587655 14 101809834 101809834 1 + 0.340 0.569 1.185
ENSG00000078304 E022 2.7611568 0.0639204654 0.092367413 0.44287934 14 101809835 101809836 2 + 0.394 0.704 1.457
ENSG00000078304 E023 4.8537101 0.0093669326 0.050210914 0.34465848 14 101809837 101809865 29 + 0.600 0.889 1.178
ENSG00000078304 E024 4.8537101 0.0093669326 0.050210914 0.34465848 14 101809866 101809868 3 + 0.600 0.889 1.178
ENSG00000078304 E025 17.9490708 0.0014849405 0.687092951 0.91080160 14 101809869 101809894 26 + 1.283 1.275 -0.028
ENSG00000078304 E026 33.8941334 0.0008806777 0.784759890 0.94368967 14 101809895 101809904 10 + 1.544 1.552 0.029
ENSG00000078304 E027 79.2597668 0.0011862106 0.799007928 0.94801568 14 101809905 101810036 132 + 1.901 1.918 0.055
ENSG00000078304 E028 0.8262777 0.0247323127 0.718325571   14 101818027 101818991 965 + 0.278 0.224 -0.410
ENSG00000078304 E029 1.3147719 0.0124485112 0.430785730   14 101818992 101819085 94 + 0.278 0.429 0.911
ENSG00000078304 E030 2.1312806 0.1968675566 0.188992637 0.59035573 14 101819086 101821098 2013 + 0.285 0.634 1.833
ENSG00000078304 E031 0.1544607 0.0313356327 0.462434090   14 101823653 101823877 225 + 0.000 0.126 10.410
ENSG00000078304 E032 0.0000000       14 101823878 101823881 4 +      
ENSG00000078304 E033 0.1767706 0.0462254584 0.519433162   14 101823882 101823941 60 + 0.114 0.000 -10.785
ENSG00000078304 E034 4.1739943 0.1897961240 0.974422679 0.99395285 14 101824014 101824161 148 + 0.698 0.737 0.158
ENSG00000078304 E035 1.4808780 0.4938144080 0.929189764   14 101824162 101824169 8 + 0.339 0.437 0.558
ENSG00000078304 E036 2.1239839 0.0804112819 0.827798352 0.95636762 14 101824170 101824478 309 + 0.484 0.527 0.209
ENSG00000078304 E037 0.0000000       14 101824838 101824922 85 +      
ENSG00000078304 E038 0.7187635 0.0992501253 0.364642033   14 101831701 101831804 104 + 0.282 0.126 -1.435
ENSG00000078304 E039 13.6586490 0.0507807464 0.598043703 0.87485275 14 101836169 101836701 533 + 1.189 1.132 -0.204
ENSG00000078304 E040 169.6745094 0.0002454670 0.124041752 0.50060121 14 101856686 101856885 200 + 2.247 2.231 -0.052
ENSG00000078304 E041 0.6351502 0.0226722052 0.034320677   14 101879222 101879363 142 + 0.000 0.370 12.442
ENSG00000078304 E042 83.1849992 0.0019303129 0.790088927 0.94500147 14 101882161 101882204 44 + 1.912 1.946 0.116
ENSG00000078304 E043 101.8815959 0.0022580962 0.918579244 0.98041858 14 101882205 101882271 67 + 2.007 2.027 0.068
ENSG00000078304 E044 54.1988698 0.1050885873 0.381034569 0.76077173 14 101882272 101883016 745 + 1.656 1.813 0.531
ENSG00000078304 E045 73.8582962 0.0031642522 0.614235765 0.88191447 14 101883257 101883301 45 + 1.882 1.882 -0.002
ENSG00000078304 E046 87.1494897 0.0064507311 0.667023500 0.90306589 14 101883302 101883349 48 + 1.925 1.975 0.169
ENSG00000078304 E047 92.8264857 0.0106974034 0.892259219 0.97415410 14 101883432 101883536 105 + 1.963 1.990 0.090
ENSG00000078304 E048 53.0411434 0.0233516404 0.354616515 0.74299087 14 101883537 101883562 26 + 1.751 1.718 -0.110
ENSG00000078304 E049 3.4714064 0.0060323319 0.066718332 0.38827801 14 101889793 101889981 189 + 0.489 0.782 1.276
ENSG00000078304 E050 2.4919761 0.0420698814 0.071314162 0.39836485 14 101889982 101890192 211 + 0.342 0.672 1.626
ENSG00000078304 E051 1.6064468 0.0114141207 0.043244325   14 101890193 101890236 44 + 0.203 0.567 2.175
ENSG00000078304 E052 71.2361732 0.0096780577 0.425327290 0.78947592 14 101890237 101890296 60 + 1.868 1.857 -0.037
ENSG00000078304 E053 108.7673964 0.0074030022 0.717883135 0.92141486 14 101893000 101893108 109 + 2.043 2.051 0.025
ENSG00000078304 E054 104.8326950 0.0141855073 0.887694386 0.97310190 14 101894507 101894560 54 + 2.012 2.046 0.114
ENSG00000078304 E055 175.2865194 0.0012878262 0.435213788 0.79450606 14 101901719 101901856 138 + 2.253 2.253 -0.001
ENSG00000078304 E056 105.3114031 0.0007314502 0.019809517 0.23464011 14 101901857 101901889 33 + 2.063 2.004 -0.197
ENSG00000078304 E057 160.8626680 0.0023097021 0.190654878 0.59239897 14 101906402 101906504 103 + 2.226 2.204 -0.074
ENSG00000078304 E058 121.1536173 0.0032075197 0.527888958 0.84394510 14 101906505 101906529 25 + 2.091 2.092 0.002
ENSG00000078304 E059 1.9834019 0.0545056945 0.268565577 0.67317599 14 101906530 101906647 118 + 0.342 0.567 1.165
ENSG00000078304 E060 140.4567424 0.0034105922 0.098682613 0.45478202 14 101909589 101909647 59 + 2.174 2.136 -0.125
ENSG00000078304 E061 122.5338153 0.0065504503 0.099027000 0.45541921 14 101909648 101909690 43 + 2.121 2.069 -0.174
ENSG00000078304 E062 93.6752549 0.0020340611 0.090385739 0.43930094 14 101912401 101912404 4 + 1.999 1.957 -0.141
ENSG00000078304 E063 132.5180795 0.0026868874 0.039951672 0.31387750 14 101912405 101912473 69 + 2.152 2.102 -0.169
ENSG00000078304 E064 66.1852237 0.0008880936 0.001409900 0.06588638 14 101912474 101912628 155 + 1.883 1.768 -0.391
ENSG00000078304 E065 1.2354715 0.0133297947 0.930503680   14 101914175 101914572 398 + 0.341 0.370 0.175
ENSG00000078304 E066 0.9545519 0.0215746235 0.950029489   14 101917769 101917830 62 + 0.278 0.303 0.173
ENSG00000078304 E067 17.4308575 0.0106464771 0.283745333 0.68651669 14 101917831 101917947 117 + 1.195 1.331 0.478
ENSG00000078304 E068 1.5818102 0.0413207907 0.183295239   14 101921093 101921382 290 + 0.277 0.526 1.404
ENSG00000078304 E069 0.8931002 0.0285370984 0.375517207   14 101921984 101922042 59 + 0.202 0.370 1.182
ENSG00000078304 E070 1.4055415 0.0121989077 0.677843996   14 101922043 101922129 87 + 0.341 0.429 0.497
ENSG00000078304 E071 0.8045307 0.0167653455 0.706547710   14 101922165 101922198 34 + 0.278 0.224 -0.411
ENSG00000078304 E072 455.4174794 0.0037571026 0.001073404 0.05638254 14 101925141 101927989 2849 + 2.590 2.721 0.434