ENSG00000072135

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000175756 ENSG00000072135 HEK293_DMSO_6hA HEK293_OSMI2_6hA PTPN18 protein_coding protein_coding 26.51979 27.79712 38.30879 1.785286 3.98579 0.4625979 7.7922175 6.583804 11.3142196 0.1271329 1.6829246 0.7802288 0.2938292 0.23853333 0.29236667 0.05383333 0.38851766 0.01415342 FALSE  
ENST00000462321 ENSG00000072135 HEK293_DMSO_6hA HEK293_OSMI2_6hA PTPN18 protein_coding retained_intron 26.51979 27.79712 38.30879 1.785286 3.98579 0.4625979 3.1424488 4.524628 4.0454538 0.6081107 0.1745897 -0.1611208 0.1207458 0.16130000 0.10736667 -0.05393333 0.22612356 0.01415342    
ENST00000483617 ENSG00000072135 HEK293_DMSO_6hA HEK293_OSMI2_6hA PTPN18 protein_coding retained_intron 26.51979 27.79712 38.30879 1.785286 3.98579 0.4625979 4.0523999 3.132838 5.1626261 0.1768162 1.3510279 0.7188290 0.1463125 0.11310000 0.12976667 0.01666667 0.85107600 0.01415342    
ENST00000489215 ENSG00000072135 HEK293_DMSO_6hA HEK293_OSMI2_6hA PTPN18 protein_coding retained_intron 26.51979 27.79712 38.30879 1.785286 3.98579 0.4625979 3.7095188 2.279592 6.7273685 0.1833265 1.3181243 1.5570946 0.1227042 0.08273333 0.17183333 0.08910000 0.01415342 0.01415342 FALSE  
ENST00000495400 ENSG00000072135 HEK293_DMSO_6hA HEK293_OSMI2_6hA PTPN18 protein_coding retained_intron 26.51979 27.79712 38.30879 1.785286 3.98579 0.4625979 0.5366483 2.112991 0.4477994 0.1552820 0.2508430 -2.2133105 0.0221000 0.07706667 0.01346667 -0.06360000 0.03113344 0.01415342 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000072135 E001 0.8871666 0.7121538002 1.000000e+00   2 130356036 130356044 9 + 0.274 0.245 -0.208
ENSG00000072135 E002 1.0683766 0.8797888675 9.551266e-01   2 130356045 130356045 1 + 0.342 0.246 -0.656
ENSG00000072135 E003 1.0683766 0.8797888675 9.551266e-01   2 130356046 130356046 1 + 0.342 0.246 -0.656
ENSG00000072135 E004 1.2934098 0.2826207888 4.530225e-01   2 130356047 130356050 4 + 0.421 0.245 -1.111
ENSG00000072135 E005 1.2934098 0.2826207888 4.530225e-01   2 130356051 130356052 2 + 0.421 0.245 -1.111
ENSG00000072135 E006 1.8121696 0.2694491938 1.988738e-01 0.602002682 2 130356053 130356054 2 + 0.561 0.245 -1.803
ENSG00000072135 E007 2.3541625 0.2300087029 2.564806e-01 0.662228115 2 130356055 130356055 1 + 0.626 0.330 -1.503
ENSG00000072135 E008 2.9327369 0.0157048326 2.007817e-02 0.236243218 2 130356056 130356065 10 + 0.722 0.329 -1.915
ENSG00000072135 E009 58.5066145 0.0071089587 1.506069e-04 0.017230727 2 130356066 130356200 135 + 1.863 1.628 -0.795
ENSG00000072135 E010 1.0852165 0.4883300470 5.878491e-01   2 130356600 130356655 56 + 0.293 0.394 0.616
ENSG00000072135 E011 0.8414724 0.0165521667 8.239168e-02   2 130358864 130358866 3 + 0.103 0.399 2.497
ENSG00000072135 E012 27.1609209 0.0051671139 7.720270e-02 0.411766774 2 130358867 130358892 26 + 1.506 1.373 -0.457
ENSG00000072135 E013 39.1775281 0.0093489185 2.426531e-02 0.255414607 2 130358893 130358949 57 + 1.668 1.505 -0.556
ENSG00000072135 E014 34.5564293 0.0103973329 1.183129e-01 0.490640620 2 130358950 130358975 26 + 1.599 1.478 -0.411
ENSG00000072135 E015 2.3451325 0.0155924356 6.580596e-01 0.899941285 2 130359177 130359232 56 + 0.533 0.460 -0.355
ENSG00000072135 E016 10.2948224 0.0023895905 2.810372e-01 0.684130944 2 130359233 130359309 77 + 1.095 0.985 -0.402
ENSG00000072135 E017 12.5353696 0.0022802582 3.107108e-01 0.708638909 2 130359397 130359492 96 + 1.172 1.077 -0.342
ENSG00000072135 E018 2.2777524 0.0449112446 2.820350e-01 0.685104008 2 130359493 130359607 115 + 0.416 0.604 0.909
ENSG00000072135 E019 11.6421726 0.0289521864 9.458171e-02 0.447312198 2 130359608 130359646 39 + 1.179 0.970 -0.759
ENSG00000072135 E020 4.2372384 0.0172439664 8.062203e-03 0.156810274 2 130359647 130359921 275 + 0.496 0.891 1.667
ENSG00000072135 E021 2.1419484 0.1215404618 1.529171e-03 0.069064421 2 130362156 130362430 275 + 0.103 0.739 4.061
ENSG00000072135 E022 18.8032823 0.1890985164 4.331305e-04 0.033124295 2 130368897 130369132 236 + 0.828 1.552 2.599
ENSG00000072135 E023 84.0071677 0.0004619271 3.361545e-05 0.006821009 2 130369133 130369201 69 + 1.996 1.833 -0.546
ENSG00000072135 E024 89.8506183 0.0040641852 3.060785e-04 0.026821771 2 130369765 130369827 63 + 2.029 1.853 -0.594
ENSG00000072135 E025 82.2114703 0.0037542477 6.595736e-03 0.143003117 2 130370048 130370088 41 + 1.971 1.838 -0.446
ENSG00000072135 E026 76.4381420 0.0019701115 6.524335e-02 0.384898365 2 130370089 130370127 39 + 1.921 1.838 -0.278
ENSG00000072135 E027 93.7033192 0.0006531616 2.711074e-02 0.267489955 2 130370128 130370190 63 + 2.008 1.926 -0.277
ENSG00000072135 E028 53.4371900 0.0157794758 6.280839e-01 0.887051421 2 130370191 130370309 119 + 1.755 1.709 -0.156
ENSG00000072135 E029 26.8478720 0.0012167425 6.132524e-01 0.881458453 2 130370310 130370390 81 + 1.433 1.466 0.115
ENSG00000072135 E030 12.4089756 0.0063238484 2.629659e-02 0.263579641 2 130370391 130370432 42 + 1.004 1.226 0.799
ENSG00000072135 E031 16.3302853 0.0942408867 3.517841e-02 0.297872600 2 130370433 130370556 124 + 1.054 1.383 1.162
ENSG00000072135 E032 57.3513630 0.0007200665 5.557075e-01 0.856312882 2 130370557 130370623 67 + 1.772 1.746 -0.089
ENSG00000072135 E033 10.5326394 0.1326729994 6.661499e-02 0.388048265 2 130370624 130370668 45 + 0.885 1.204 1.167
ENSG00000072135 E034 8.4254325 0.0753726307 4.042899e-02 0.315579986 2 130370669 130370704 36 + 0.792 1.116 1.214
ENSG00000072135 E035 51.6682854 0.0145786381 7.142826e-01 0.920184926 2 130370705 130370746 42 + 1.727 1.705 -0.075
ENSG00000072135 E036 42.6961927 0.0092498881 5.894849e-01 0.871129195 2 130370747 130370782 36 + 1.613 1.660 0.159
ENSG00000072135 E037 7.1944004 0.0851692647 3.621869e-02 0.301247920 2 130370783 130370874 92 + 0.711 1.063 1.354
ENSG00000072135 E038 68.9186072 0.0047442057 9.000215e-01 0.976157196 2 130370875 130370964 90 + 1.843 1.839 -0.014
ENSG00000072135 E039 70.8931031 0.0026366626 7.955478e-01 0.946662898 2 130371199 130371287 89 + 1.858 1.848 -0.033
ENSG00000072135 E040 4.0855800 0.0057516160 2.581251e-03 0.090974654 2 130371288 130371313 26 + 0.457 0.891 1.862
ENSG00000072135 E041 5.9446324 0.0610858929 7.897262e-02 0.415351208 2 130371998 130372088 91 + 0.683 0.966 1.111
ENSG00000072135 E042 13.7862405 0.0020360667 2.260823e-01 0.631183123 2 130372089 130372256 168 + 1.105 1.216 0.396
ENSG00000072135 E043 98.6625779 0.0002964888 7.811873e-01 0.942502565 2 130372257 130372483 227 + 1.999 1.991 -0.029
ENSG00000072135 E044 19.8474838 0.0075405529 7.606990e-05 0.011596566 2 130372608 130372872 265 + 1.124 1.467 1.200
ENSG00000072135 E045 82.1867103 0.0004525957 7.141829e-01 0.920139770 2 130372873 130372947 75 + 1.908 1.924 0.053
ENSG00000072135 E046 101.5172024 0.0003015908 4.083370e-01 0.779204272 2 130373157 130373220 64 + 1.991 2.021 0.100
ENSG00000072135 E047 821.0028921 0.0001141233 1.483039e-07 0.000135029 2 130373221 130374665 1445 + 2.883 2.942 0.195
ENSG00000072135 E048 482.3125492 0.0017625205 8.248531e-01 0.955653791 2 130374666 130375405 740 + 2.680 2.680 0.001