ENSG00000071994

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000167218 ENSG00000071994 HEK293_DMSO_6hA HEK293_OSMI2_6hA PDCD2 protein_coding nonsense_mediated_decay 121.7042 95.0695 89.80198 8.189247 8.872054 -0.08222628 8.856291 7.602166 7.232429 0.8375588 0.7157156 -0.07183341 0.07307917 0.08130000 0.08066667 -0.0006333333 0.99749169 0.01946365 TRUE TRUE
ENST00000392090 ENSG00000071994 HEK293_DMSO_6hA HEK293_OSMI2_6hA PDCD2 protein_coding protein_coding 121.7042 95.0695 89.80198 8.189247 8.872054 -0.08222628 38.355708 33.109436 24.005884 3.6433391 2.8484691 -0.46368918 0.31547083 0.34673333 0.26683333 -0.0799000000 0.01946365 0.01946365 FALSE TRUE
ENST00000453163 ENSG00000071994 HEK293_DMSO_6hA HEK293_OSMI2_6hA PDCD2 protein_coding protein_coding 121.7042 95.0695 89.80198 8.189247 8.872054 -0.08222628 7.400461 4.728580 5.364365 0.8846708 0.2299336 0.18163963 0.06179167 0.04946667 0.06053333 0.0110666667 0.72861776 0.01946365 FALSE TRUE
ENST00000544866 ENSG00000071994 HEK293_DMSO_6hA HEK293_OSMI2_6hA PDCD2 protein_coding nonsense_mediated_decay 121.7042 95.0695 89.80198 8.189247 8.872054 -0.08222628 29.082080 24.832121 27.403135 2.1774527 2.9450222 0.14207893 0.23871250 0.26180000 0.30483333 0.0430333333 0.33628065 0.01946365 FALSE TRUE
ENST00000614056 ENSG00000071994 HEK293_DMSO_6hA HEK293_OSMI2_6hA PDCD2 protein_coding protein_coding 121.7042 95.0695 89.80198 8.189247 8.872054 -0.08222628 20.566014 12.984012 17.808696 2.5168717 2.8044892 0.45554480 0.17019583 0.13526667 0.19636667 0.0611000000 0.27090084 0.01946365 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000071994 E001 0.8654196 2.739379e-02 5.128550e-01   6 170575295 170575327 33 - 0.316 0.195 -0.915
ENSG00000071994 E002 207.8567275 7.704066e-03 3.545974e-01 0.74299019 6 170575328 170577435 2108 - 2.294 2.327 0.109
ENSG00000071994 E003 222.7240353 1.580870e-03 3.649617e-02 0.30209110 6 170577436 170577558 123 - 2.310 2.362 0.172
ENSG00000071994 E004 244.6534499 1.629752e-04 9.455023e-05 0.01313619 6 170577559 170577593 35 - 2.333 2.411 0.258
ENSG00000071994 E005 394.1395303 1.675111e-03 5.346877e-03 0.13074010 6 170577594 170577717 124 - 2.551 2.611 0.200
ENSG00000071994 E006 4.2785586 6.474342e-03 6.155277e-02 0.37567118 6 170578482 170578488 7 - 0.542 0.805 1.118
ENSG00000071994 E007 6.1817977 3.940376e-03 1.026772e-02 0.17563467 6 170578489 170578506 18 - 0.622 0.951 1.315
ENSG00000071994 E008 201.5167653 8.039155e-03 5.650906e-01 0.85997261 6 170578507 170578656 150 - 2.322 2.279 -0.143
ENSG00000071994 E009 421.6264239 3.560964e-03 3.437975e-01 0.73487029 6 170578857 170578882 26 - 2.606 2.624 0.061
ENSG00000071994 E010 564.9856817 3.158421e-03 3.203517e-01 0.71680025 6 170578883 170578970 88 - 2.735 2.750 0.052
ENSG00000071994 E011 36.1520873 1.201034e-02 8.828791e-02 0.43481645 6 170578971 170579721 751 - 1.487 1.608 0.415
ENSG00000071994 E012 578.9057017 1.766571e-03 2.407416e-01 0.64577997 6 170580002 170580092 91 - 2.745 2.761 0.051
ENSG00000071994 E013 357.3690125 6.155034e-04 1.441661e-02 0.20507866 6 170580093 170580105 13 - 2.520 2.560 0.135
ENSG00000071994 E014 92.9340821 1.617084e-02 4.702024e-01 0.81397355 6 170581089 170581744 656 - 2.004 1.938 -0.223
ENSG00000071994 E015 22.9258646 1.287088e-03 6.586138e-01 0.90010908 6 170581745 170581746 2 - 1.355 1.374 0.069
ENSG00000071994 E016 24.5226820 1.235156e-03 8.492460e-01 0.96286592 6 170581747 170581747 1 - 1.394 1.395 0.004
ENSG00000071994 E017 55.0848684 8.356441e-03 1.710949e-01 0.56846042 6 170581748 170581791 44 - 1.797 1.693 -0.350
ENSG00000071994 E018 429.6446383 2.457573e-02 5.542047e-02 0.35929852 6 170581792 170582265 474 - 2.712 2.556 -0.520
ENSG00000071994 E019 181.8660933 6.165087e-02 3.535965e-01 0.74229156 6 170582266 170582848 583 - 2.326 2.199 -0.425
ENSG00000071994 E020 88.2123676 4.000629e-02 5.974026e-01 0.87449903 6 170582849 170583056 208 - 1.981 1.915 -0.222
ENSG00000071994 E021 912.3625508 7.962224e-05 6.431254e-01 0.89368279 6 170583057 170583188 132 - 2.962 2.944 -0.061
ENSG00000071994 E022 762.4870155 6.069602e-04 4.149885e-01 0.78343229 6 170583505 170583623 119 - 2.890 2.863 -0.092
ENSG00000071994 E023 564.8179656 1.689337e-03 5.864199e-01 0.86969698 6 170583624 170583747 124 - 2.746 2.744 -0.007
ENSG00000071994 E024 3.6638439 1.053057e-01 7.376241e-01 0.92818764 6 170584055 170584298 244 - 0.626 0.692 0.280
ENSG00000071994 E025 297.8437900 4.806579e-03 3.316222e-01 0.72580381 6 170584299 170584392 94 - 2.497 2.447 -0.167
ENSG00000071994 E026 153.3228801 5.582317e-03 1.965824e-02 0.23400233 6 170584393 170584491 99 - 2.248 2.128 -0.402
ENSG00000071994 E027 95.7829186 1.916867e-02 2.474364e-02 0.25754254 6 170584492 170584692 201 - 2.077 1.894 -0.614